DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4896 and rbm-5

DIOPT Version :10

Sequence 1:NP_608583.5 Gene:CG4896 / 33305 FlyBaseID:FBgn0031319 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_491793.1 Gene:rbm-5 / 172312 WormBaseID:WBGene00020346 Length:925 Species:Caenorhabditis elegans


Alignment Length:1024 Identity:257/1024 - (25%)
Similarity:392/1024 - (38%) Gaps:284/1024 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 SGGN-GNGSESGYRRYSRSRSRSRE----RSRDRNEYRRRNSRSRSRERSSHYRNDRSPDRDLYR 69
            ||.| .:.|.|..|...|||||||:    |||.|:..|||.||.|..:|||..|.|||..|    
 Worm   102 SGENKSSRSPSWAREARRSRSRSRDRRGGRSRSRSPSRRRTSRDRRDDRSSRRRRDRSHSR---- 162

  Fly    70 DLINEDYEDQGNYNSRQNLDQRHGEDKYDRRHADSQGRRDHDSNYDKSGQDMDKDRDHRWKNYDR 134
                          ||......:|..                                .|.:.:|
 Worm   163 --------------SRSPPSSANGSS--------------------------------HWSSSNR 181

  Fly   135 VSRERNHDDFDRGSERSSRSNDQRQFNNNGNSNSSSSYRDREKERDRDRRCSSDEDSDMASEFRQ 199
            .||.|....:.|..:|:||.:|:|     .|.:::..|.|                         
 Worm   182 HSRRRRSRSYSRERDRNSRRDDRR-----SNLSNNDRYSD------------------------- 216

  Fly   200 RGAYNSGSSVEPLNNIILFGLKKHVTEADIMGELIKVDLEPTSIRVMRK--QQTGASRCFAFVEF 262
               :|.|   .|.|.:.:..:...|....|...|.|....|..:|.|.|  :.|...|.||||||
 Worm   217 ---WNPG---VPSNKLAILNMPNDVDNTKITLSLGKCGYLPQDVRTMTKFDKNTKQIRTFAFVEF 275

  Fly   263 KTVEEATRWMELTQGVLQLGDHR-VTMQY--------SHTRISDWTCIKCGASNFKRRFQCYMCN 318
            ...|.|.:||...:|.|.|.|.| :.::|        |..:..||.|..|..:||.:|..|:.|.
 Worm   276 SNRETAEQWMTDYEGWLTLDDGRTLAVEYAKGDPAAGSGNKGDDWICAHCSMNNFVKRQTCFKCE 340

  Fly   319 ASRAES---ENALYGAGEGVDEISQILTKKIMLRGL-DALTN-----EEGVLTALQQRLPELAKT 374
            .|:.:|   |..      |...:.......:::||| |.:.|     ..|.|..|        .:
 Worm   341 ISKDQSMELEKL------GAHMVGMTPCDTLLIRGLPDGINNSLIFDSLGALVCL--------SS 391

  Fly   375 VSKVLVSRDALTNASRGICYLNFDTLIDSMNVFNGLTALDPPLTLDDKTVIVTYCIDSENR---Q 436
            :|.:.:|.      |:...||...:..::..:.| || ...|:.:.||.|.|::|.||.::   |
 Worm   392 ISMIKLSE------SKRFAYLQMKSADEAKMLLN-LT-YKSPIRIKDKDVQVSWCRDSMSKLIQQ 448

  Fly   437 MMP-----------AEGNFFRAGETAMSPSAITAAYTLADVPRLA-EYSASVYASNPLEHANYVQ 489
            .|.           |.|:..:...|....:|  ||.:.|:..|.| :....:....|...||.:.
 Worm   449 QMTMLTAGPGKNSVATGSLAQGNMTGAEIAA--AALSKANAVRQASQQVGQIMTGLPAPAANMIP 511

  Fly   490 YYTDYYTTEISKNCRDRQVTEANSGAAVALSAIQRKQRKVSQMETTVSVTEAKVAFLARGESAPK 554
                          .:..|...|......:.|.|.:.:     ...:.:|:.....|.|      
 Worm   512 --------------PNFSVPPPNLSVPPPMQATQPEHQ-----NGVIGMTQTPKGLLPR------ 551

  Fly   555 GNDGKKYDTPDVSKYQYDETSGYYYDHVTGLYYDAHSQYYYNNETGAYLYWDQKRSTYVLATPAS 619
                  |..|:...:.:|...|||.|.:|...||:.:.||:||.|..:..||....||.   |..
 Worm   552 ------YLPPNPLTFAHDPNLGYYVDPITKFCYDSATGYYFNNATSQWCNWDLTHHTYF---PVE 607

  Fly   620 TQAALKEVLADAEKKEEEAKKAKEKEKEKEEAGGKPDKVKVAKKIVKDMEKWAKQLNQKKDYTAV 684
            |.|    |:..|:.:||:.||.:|..             |.|:.:||||.||||:  |:||...|
 Worm   608 TPA----VINSADPEEEKMKKNEEGP-------------KTAQDLVKDMAKWAKR--QEKDKKKV 653

  Fly   685 ATPQPILSDTEAATTSRASQGAYADVGFSILEKKELGK---LNDYVPEAGPPAISKLVGAYGGPS 746
                      :.:...:.::|......||..::|.:.:   |.|                    .
 Worm   654 ----------QISIKGKETKGIELKNVFSNEKQKRIAQTAALFD--------------------D 688

  Fly   747 DSEDDNS---ANQKALEASVGT----------KRAISDESDYV-----DFQKLTCLLCMRAFQSL 793
            |.|:|..   ..:::.|.|..:          |..:.|..|.:     |..|.||:||.|||..:
 Worm   689 DEEEDQEEEVRGRRSEEPSTSSSFSSVPLAPRKSTLQDVRDAMERALYDETKKTCMLCKRAFSDV 753

  Fly   794 DILQKHLKMSNLHKENLDKLK----RNPAVEAGTDE---------GLSYRDRAKERRLKYGESDP 845
            ::|:||::.|:||:.||:..:    |..|.:...:|         .:.|||||||||.::|....
 Worm   754 EVLRKHVEKSDLHRNNLEAKRAEWGRETAAKLQEEEEDASAPDLPKIVYRDRAKERRRQFGIDST 818

  Fly   846 --------PPPNRSRERFEQEIKTLQSRQKDSFGATAAMPISSTNVGSRLMQKMGWSEGQGLGKK 902
                    .||..:..|.|:.|:.:...       .:..|:..:|:|:||::.|||.||||:||.
 Worm   819 GYAFDVMGGPPGPTSVRHEETIRKVSEE-------ASKRPLDESNIGNRLLKSMGWKEGQGVGKH 876

  Fly   903 NQGRTEIIEADGRSNNVGLGNNTGHMAPGND--YKSYIKKMMKQRYENA 949
            .||....|||:......|||.....|..|.:  :|...::.:..||.:|
 Worm   877 AQGIVNPIEAERFVQGAGLGAAGSKMRHGAEASHKEKTRQALYSRYHDA 925

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4896NP_608583.5 U2AF_lg 74..>158 CDD:273727 13/83 (16%)
RRM1_RBM5_like 211..291 CDD:409977 28/90 (31%)
ZnF_RBZ 296..320 CDD:197784 9/23 (39%)
RanBP2-type Zn finger 298..317 CDD:275376 7/18 (39%)
RRM1_RRM2_RBM5_like 343..429 CDD:409752 21/91 (23%)
OCRE_RBM5_like 562..617 CDD:293881 18/54 (33%)
OCRE repeat 1 567..574 CDD:293881 1/6 (17%)
OCRE repeat 2 575..582 CDD:293881 4/6 (67%)
OCRE repeat 3 583..590 CDD:293881 3/6 (50%)
OCRE repeat 4 591..598 CDD:293881 3/6 (50%)
OCRE repeat 5 600..607 CDD:293881 1/6 (17%)
G-patch 882..924 CDD:396249 21/41 (51%)
rbm-5NP_491793.1 RRM_SF 222..305 CDD:473069 27/82 (33%)
ZnF_RBZ 318..340 CDD:197784 8/21 (38%)
RanBP2-type Zn finger 320..339 CDD:275376 7/18 (39%)
RRM_SF 361..438 CDD:473069 21/92 (23%)
OCRE_RBM5_like 554..608 CDD:293881 19/56 (34%)
OCRE repeat 1 558..565 CDD:293881 1/6 (17%)
OCRE repeat 2 566..573 CDD:293881 4/6 (67%)
OCRE repeat 3 574..581 CDD:293881 3/6 (50%)
OCRE repeat 4 582..589 CDD:293881 3/6 (50%)
OCRE repeat 5 591..598 CDD:293881 1/6 (17%)
RED_N 785..>849 CDD:462273 16/70 (23%)
G_patch 852..898 CDD:197727 21/45 (47%)

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