DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4896 and rbm-5

DIOPT Version :9

Sequence 1:	NP_608583.5	Gene:	CG4896 / 33305	FlyBaseID:	FBgn0031319	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_491793.1	Gene:	rbm-5 / 172312	WormBaseID:	WBGene00020346	Length:	925	Species:	Caenorhabditis elegans

Alignment Length:	1024	Identity:	257/1024 - (25%)
Similarity:	392/1024 - (38%)	Gaps:	284/1024 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SGGN-GNGSESGYRRYSRSRSRSRE----RSRDRNEYRRRNSRSRSRERSSHYRNDRSPDRDLYR 69
            ||.| .:.|.|..|...|||||||:    |||.|:..|||.||.|..:|||..|.|||..|
Worm   102 SGENKSSRSPSWAREARRSRSRSRDRRGGRSRSRSPSRRRTSRDRRDDRSSRRRRDRSHSR---- 162

  Fly    70 DLINEDYEDQGNYNSRQNLDQRHGEDKYDRRHADSQGRRDHDSNYDKSGQDMDKDRDHRWKNYDR 134
                          ||......:|..                                .|.:.:|
Worm   163 --------------SRSPPSSANGSS--------------------------------HWSSSNR 181

  Fly   135 VSRERNHDDFDRGSERSSRSNDQRQFNNNGNSNSSSSYRDREKERDRDRRCSSDEDSDMASEFRQ 199
            .||.|....:.|..:|:||.:|:|     .|.:::..|.|
Worm   182 HSRRRRSRSYSRERDRNSRRDDRR-----SNLSNNDRYSD------------------------- 216

  Fly   200 RGAYNSGSSVEPLNNIILFGLKKHVTEADIMGELIKVDLEPTSIRVMRK--QQTGASRCFAFVEF 262
               :|.|   .|.|.:.:..:...|....|...|.|....|..:|.|.|  :.|...|.||||||
Worm   217 ---WNPG---VPSNKLAILNMPNDVDNTKITLSLGKCGYLPQDVRTMTKFDKNTKQIRTFAFVEF 275

  Fly   263 KTVEEATRWMELTQGVLQLGDHR-VTMQY--------SHTRISDWTCIKCGASNFKRRFQCYMCN 318
            ...|.|.:||...:|.|.|.|.| :.::|        |..:..||.|..|..:||.:|..|:.|.
Worm   276 SNRETAEQWMTDYEGWLTLDDGRTLAVEYAKGDPAAGSGNKGDDWICAHCSMNNFVKRQTCFKCE 340

  Fly   319 ASRAES---ENALYGAGEGVDEISQILTKKIMLRGL-DALTN-----EEGVLTALQQRLPELAKT 374
            .|:.:|   |..      |...:.......:::||| |.:.|     ..|.|..|        .:
Worm   341 ISKDQSMELEKL------GAHMVGMTPCDTLLIRGLPDGINNSLIFDSLGALVCL--------SS 391

  Fly   375 VSKVLVSRDALTNASRGICYLNFDTLIDSMNVFNGLTALDPPLTLDDKTVIVTYCIDSENR---Q 436
            :|.:.:|.      |:...||...:..::..:.| || ...|:.:.||.|.|::|.||.::   |
Worm   392 ISMIKLSE------SKRFAYLQMKSADEAKMLLN-LT-YKSPIRIKDKDVQVSWCRDSMSKLIQQ 448

  Fly   437 MMP-----------AEGNFFRAGETAMSPSAITAAYTLADVPRLA-EYSASVYASNPLEHANYVQ 489
            .|.           |.|:..:...|....:|  ||.:.|:..|.| :....:....|...||.:.
Worm   449 QMTMLTAGPGKNSVATGSLAQGNMTGAEIAA--AALSKANAVRQASQQVGQIMTGLPAPAANMIP 511

  Fly   490 YYTDYYTTEISKNCRDRQVTEANSGAAVALSAIQRKQRKVSQMETTVSVTEAKVAFLARGESAPK 554
                          .:..|...|......:.|.|.:.:     ...:.:|:.....|.|
Worm   512 --------------PNFSVPPPNLSVPPPMQATQPEHQ-----NGVIGMTQTPKGLLPR------ 551

  Fly   555 GNDGKKYDTPDVSKYQYDETSGYYYDHVTGLYYDAHSQYYYNNETGAYLYWDQKRSTYVLATPAS 619
                  |..|:...:.:|...|||.|.:|...||:.:.||:||.|..:..||....||.   |..
Worm   552 ------YLPPNPLTFAHDPNLGYYVDPITKFCYDSATGYYFNNATSQWCNWDLTHHTYF---PVE 607

  Fly   620 TQAALKEVLADAEKKEEEAKKAKEKEKEKEEAGGKPDKVKVAKKIVKDMEKWAKQLNQKKDYTAV 684
            |.|    |:..|:.:||:.||.:|..             |.|:.:||||.||||:  |:||...|
Worm   608 TPA----VINSADPEEEKMKKNEEGP-------------KTAQDLVKDMAKWAKR--QEKDKKKV 653

  Fly   685 ATPQPILSDTEAATTSRASQGAYADVGFSILEKKELGK---LNDYVPEAGPPAISKLVGAYGGPS 746
                      :.:...:.::|......||..::|.:.:   |.|                    .
Worm   654 ----------QISIKGKETKGIELKNVFSNEKQKRIAQTAALFD--------------------D 688

  Fly   747 DSEDDNS---ANQKALEASVGT----------KRAISDESDYV-----DFQKLTCLLCMRAFQSL 793
            |.|:|..   ..:::.|.|..:          |..:.|..|.:     |..|.||:||.|||..:
Worm   689 DEEEDQEEEVRGRRSEEPSTSSSFSSVPLAPRKSTLQDVRDAMERALYDETKKTCMLCKRAFSDV 753

  Fly   794 DILQKHLKMSNLHKENLDKLK----RNPAVEAGTDE---------GLSYRDRAKERRLKYGESDP 845
            ::|:||::.|:||:.||:..:    |..|.:...:|         .:.|||||||||.::|....
Worm   754 EVLRKHVEKSDLHRNNLEAKRAEWGRETAAKLQEEEEDASAPDLPKIVYRDRAKERRRQFGIDST 818

  Fly   846 --------PPPNRSRERFEQEIKTLQSRQKDSFGATAAMPISSTNVGSRLMQKMGWSEGQGLGKK 902
                    .||..:..|.|:.|:.:...       .:..|:..:|:|:||::.|||.||||:||.
Worm   819 GYAFDVMGGPPGPTSVRHEETIRKVSEE-------ASKRPLDESNIGNRLLKSMGWKEGQGVGKH 876

  Fly   903 NQGRTEIIEADGRSNNVGLGNNTGHMAPGND--YKSYIKKMMKQRYENA 949
            .||....|||:......|||.....|..|.:  :|...::.:..||.:|
Worm   877 AQGIVNPIEAERFVQGAGLGAAGSKMRHGAEASHKEKTRQALYSRYHDA 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4896	NP_608583.5	DUF1777	91..>158	CDD:285811	11/66 (17%)
		RRM1_RBM5_like	211..291	CDD:241005	28/90 (31%)
		ZnF_RBZ	296..320	CDD:197784	9/23 (39%)
		RanBP2-type Zn finger	298..317	CDD:275376	7/18 (39%)
		RRM1_RRM2_RBM5_like	343..429	CDD:240759	21/91 (23%)
		OCRE_RBM5_like	562..617	CDD:293881	18/54 (33%)
		OCRE repeat 1	567..574	CDD:293881	1/6 (17%)
		OCRE repeat 2	575..582	CDD:293881	4/6 (67%)
		OCRE repeat 3	583..590	CDD:293881	3/6 (50%)
		OCRE repeat 4	591..598	CDD:293881	3/6 (50%)
		OCRE repeat 5	600..607	CDD:293881	1/6 (17%)
		G-patch	882..922	CDD:279867	19/39 (49%)
rbm-5	NP_491793.1	RRM	<218..>308	CDD:223796	30/92 (33%)
		RRM_SF	222..305	CDD:302621	27/82 (33%)
		ZnF_RBZ	318..340	CDD:197784	8/21 (38%)
		RanBP2-type Zn finger	320..339	CDD:275375	7/18 (39%)
		RRM_SF	361..438	CDD:302621	21/92 (23%)
		OCRE_RBM5_like	554..608	CDD:293881	19/56 (34%)
		OCRE repeat 1	558..565	CDD:293881	1/6 (17%)
		OCRE repeat 2	566..573	CDD:293881	4/6 (67%)
		OCRE repeat 3	574..581	CDD:293881	3/6 (50%)
		OCRE repeat 4	582..589	CDD:293881	3/6 (50%)
		OCRE repeat 5	591..598	CDD:293881	1/6 (17%)
		RED_N	784..>849	CDD:285099	16/71 (23%)
		G_patch	852..898	CDD:197727	21/45 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167830
Domainoid	1	1.000	75	1.000	Domainoid score	I5902
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	222	1.000	Inparanoid score	I2267
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55750
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	1	1.000	-	-		FOG0002462
OrthoInspector	1	1.000	-	-		otm14220
orthoMCL	1	0.900	-	-		OOG6_102541
Panther	1	1.100	-	-	O	PTHR13948
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1777
SonicParanoid	1	1.000	-	-		X1642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.940