DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4896 and RBM5

DIOPT Version :9

Sequence 1:NP_608583.5 Gene:CG4896 / 33305 FlyBaseID:FBgn0031319 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_005769.1 Gene:RBM5 / 10181 HGNCID:9902 Length:815 Species:Homo sapiens


Alignment Length:907 Identity:289/907 - (31%)
Similarity:435/907 - (47%) Gaps:147/907 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 SRQNLDQRHGE--DKYDRRHADSQGRRDHDSNYDKSGQDMDKDRDHRWKNYDRVSRERNHDDFDR 146
            ||.....|:|.  |:.||...:|:.|| .||:|.:|..|...||...:::||...|||...:.||
Human     8 SRTERSGRYGSIIDRDDRDERESRSRR-RDSDYKRSSDDRRGDRYDDYRDYDSPERERERRNSDR 71

  Fly   147 GSERSSRSNDQRQFNNNGNSNSSSSYRDREKERDRDRRCSSDEDSDMASEFRQRGAYNSGSSVEP 211
            ..:               ..:|...|.:.:...|     .|||...                   
Human    72 SED---------------GYHSDGDYGEHDYRHD-----ISDERES------------------- 97

  Fly   212 LNNIILFGLKKHVTEADIMGELIKVD-LEPTSIRVMRKQQTGASRCFAFVEFKTVEEATRWMELT 275
             ..|:|.||...:||:||...:...: .:|..:|:| |::||.||.||||||..:::||.|||..
Human    98 -KTIMLRGLPITITESDIREMMESFEGPQPADVRLM-KRKTGVSRGFAFVEFYHLQDATSWMEAN 160

  Fly   276 QGVLQLGDHRVTMQYSHTR--ISDWTCIKCGASNFKRRFQCYMCNASRAESENAL-YGAGEGVDE 337
            |..|.:....:.|.||:.|  ..||.|.||..:||::|.:|:.|.|.:.:||..: .|..|.|..
Human   161 QKKLVIQGKHIAMHYSNPRPKFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEVPPGTTESVQS 225

  Fly   338 ISQILTKKIMLRGLDALTNEEGVLTALQQRLPELAKTVSKVLVSRDALTNASRGICYLNFDTLID 402
            : ......|:||.:...|..:.::|||.   |..:..|:.:.:.:|..|..:||..::...:.:|
Human   226 V-DYYCDTIILRNIAPHTVVDSIMTALS---PYASLAVNNIRLIKDKQTQQNRGFAFVQLSSAMD 286

  Fly   403 SMNVFNGLTALDPPLTLDDKTVIVTYCIDSENRQMMPAEGNFFRAGETAMSPSAITAAYTLADVP 467
            :..:...|.:|.|||.:|.||:.|.:. .|..:.::.::||  |....:::.:||.||...:...
Human   287 ASQLLQILQSLHPPLKIDGKTIGVDFA-KSARKDLVLSDGN--RVSAFSVASTAIAAAQWSSTQS 348

  Fly   468 RLAEYSASVYA------SNPLEHANYVQYYTDYYTTE---ISKNCRDRQVTEANSGAAVALSAIQ 523
            :..|..:..|:      ....::|.|.|.|..:|..:   :..:......|...:.:|..:|...
Human   349 QSGEGGSVDYSYLQPGQDGYAQYAQYSQDYQQFYQQQAGGLESDASSASGTAVTTTSAAVVSQSP 413

  Fly   524 RKQRKVS----------QMETTVSVTEAKVAFLARGESAPKG-NDGKKYDTPDVSKYQYDETSGY 577
            :...:.|          |..|:.| |:|..|       :|.| ..|.||..||.|.|||||:|||
Human   414 QLYNQTSNPPGSPTEEAQPSTSTS-TQAPAA-------SPTGVVPGTKYAVPDTSTYQYDESSGY 470

  Fly   578 YYDHVTGLYYDAHSQYYYNNETGAYLYWDQKRSTYVLATPAST--QAALKEVLADAEKKEEEAKK 640
            |||..||||||.:||||||:.|..|||||.::.|||.|..:|:  |:.|           ..||:
Human   471 YYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPAAESSSHQQSGL-----------PPAKE 524

  Fly   641 AKEKEKEKEEAGGKPDKVKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILSDTEAATTSRASQG 705
            .||| |||       .|.|.|::|.||||:|||.||::|: ....:.||:.|..|    ....:.
Human   525 GKEK-KEK-------PKSKTAQQIAKDMERWAKSLNKQKE-NFKNSFQPVNSLRE----EERRES 576

  Fly   706 AYADVGFSILEKK-ELGKLNDYVPE------AGPPAISKLVGAYGGPSDSEDDNSANQKALEASV 763
            |.||.||::.||| .|.:....:||      ...|....||.||.|.||:|::.           
Human   577 AAADAGFALFEKKGALAERQQLIPELVRNGDEENPLKRGLVAAYSGDSDNEEEL----------- 630

  Fly   764 GTKRAISDESDYVDFQKLTCLLCMRAFQSLDILQKHLKMSNLHKENLDKLKRN-------PAVEA 821
             .:|..|:|....|::|:.||||.|.|.:.|.|.:|.::|:|||:|:|..:|:       .|:|.
Human   631 -VERLESEEEKLADWKKMACLLCRRQFPNKDALVRHQQLSDLHKQNMDIYRRSRLSEQELEALEL 694

  Fly   822 GTDEGLSYRDRAKERRLKYGESDPPPPNRSRERFEQEIKTLQSRQKDSFGATAAMPISSTNVGSR 886
            ...| :.|||||.|||.|||..:||.|.| :::|:......:...||.        |..:|:|::
Human   695 RERE-MKYRDRAAERREKYGIPEPPEPKR-KKQFDAGTVNYEQPTKDG--------IDHSNIGNK 749

  Fly   887 LMQKMGWSEGQGLGKKNQGRTEIIEADGRSNNVGLG-NNTGHMAPGND-YKSYIKKMMKQRY 946
            ::|.|||.||.|||:|.||.|..|||..|....||| ..:.:...|.| ||..::|.|..|:
Human   750 MLQAMGWREGSGLGRKCQGITAPIEAQVRLKGAGLGAKGSAYGLSGADSYKDAVRKAMFARF 811

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4896NP_608583.5 DUF1777 91..>158 CDD:285811 22/68 (32%)
RRM1_RBM5_like 211..291 CDD:241005 30/80 (38%)
ZnF_RBZ 296..320 CDD:197784 10/23 (43%)
RanBP2-type Zn finger 298..317 CDD:275376 8/18 (44%)
RRM1_RRM2_RBM5_like 343..429 CDD:240759 23/85 (27%)
OCRE_RBM5_like 562..617 CDD:293881 36/54 (67%)
OCRE repeat 1 567..574 CDD:293881 5/6 (83%)
OCRE repeat 2 575..582 CDD:293881 6/6 (100%)
OCRE repeat 3 583..590 CDD:293881 6/6 (100%)
OCRE repeat 4 591..598 CDD:293881 6/6 (100%)
OCRE repeat 5 600..607 CDD:293881 4/6 (67%)
G-patch 882..922 CDD:279867 20/39 (51%)
RBM5NP_005769.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..93 27/105 (26%)
RRM 40..>181 CDD:223796 50/181 (28%)
RRM1_RBM5 93..179 CDD:241196 34/106 (32%)
zf-RanBP 181..210 CDD:279035 11/28 (39%)
RanBP2-type Zn finger 185..204 CDD:275375 8/18 (44%)
RRM2_RBM5 229..314 CDD:241199 23/88 (26%)
Required for interaction with U2AF2. /evidence=ECO:0000269|PubMed:18851835 321..809 185/543 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 411..468 20/64 (31%)
Sufficient for interaction with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200. /evidence=ECO:0000269|PubMed:18851835 452..535 50/101 (50%)
OCRE_RBM5 455..510 CDD:293887 36/54 (67%)
OCRE repeat 1 460..467 CDD:293887 5/6 (83%)
OCRE repeat 2 468..475 CDD:293887 6/6 (100%)
OCRE repeat 3 476..483 CDD:293887 6/6 (100%)
OCRE repeat 4 484..491 CDD:293887 6/6 (100%)
OCRE repeat 5 493..500 CDD:293887 4/6 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..540 15/51 (29%)
G-patch 743..787 CDD:279867 22/43 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152940
Domainoid 1 1.000 124 1.000 Domainoid score I5526
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 371 1.000 Inparanoid score I2130
Isobase 1 0.950 - 0 Normalized mean entropy S4453
OMA 1 1.010 - - QHG55750
OrthoDB 1 1.010 - - D786674at2759
OrthoFinder 1 1.000 - - FOG0002462
OrthoInspector 1 1.000 - - mtm8631
orthoMCL 1 0.900 - - OOG6_102541
Panther 1 1.100 - - O PTHR13948
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1777
SonicParanoid 1 1.000 - - X1642
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.890

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