DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4887 and SQS1

DIOPT Version :9

Sequence 1:	NP_001259859.1	Gene:	CG4887 / 33304	FlyBaseID:	FBgn0031318	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_014175.1	Gene:	SQS1 / 855497	SGDID:	S000005168	Length:	767	Species:	Saccharomyces cerevisiae

Alignment Length:	1040	Identity:	187/1040 - (17%)
Similarity:	346/1040 - (33%)	Gaps:	363/1040 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RGSDYYRSRPGSRYSRSRSRSRERNRSHG-GIRHRNSRSRSRDRDRSPVFRNDQHRGGRGGAGNG 82
            |.|.|..||  .|::|. |.|::..|.:. ||:.|..:       :.|...|..|.... ..|.|
Yeast     4 RHSHYQGSR--RRHARG-SNSKKAGRGNAKGIQGRKIK-------KKPTPTNSWHNSSI-PLGEG 57

  Fly    83 DPD------------LYHSLINDDY--RDQDERN-----------YNS-------RSNFENR--Q 113
            |.|            :....|.|.|  ||...|:           |:|       |:.|..|  |
Yeast    58 DLDDVGADFNPGRAFISPKTIEDYYFGRDAKSRSMKMGGLRPGNRYDSSTDLQAGRAAFRKRPMQ 122

  Fly   114 F-RRHDSFDRRHR--DRDGESDRELNDYEYEQRSRDL-DSRDRSSTDRDWYHNRSRSREHSRPWN 174
            | :..:.:|..|.  .:....:...|..|..:|..|: :...:.::|.::.:|..
Yeast   123 FVKAKEVYDPSHNMIQKLRAKNETKNSEEIVEREADVFEEPGKMTSDVEYINNED---------- 177

  Fly   175 RNNNHDDRSRSNERNTRHRDHRMYNGGGSNHNRDRDRDRDREQDRERDRDRDRDRERRGSSDYDS 239
             :.|.||.|    :|:...||.:    .||.::..|.|
Yeast   178 -SENEDDDS----QNSPSTDHSL----SSNESKVEDGD--------------------------- 206

  Fly   240 DEGHMRRNKYRSTTEALNIIIIFGLTKEMTRADIMSELIKVNMEPACIRIIRKQGTDSSRGIAFV 304
                                 :|.:.:|..::..::::.:|     ||..|.:     .|.:| :
Yeast   207 ---------------------LFFVDEEAQQSPDLTKIKRV-----CIEEIAR-----PREVA-I 239

  Fly   305 EFNTVEEAKQWMDITQGVLKLNDERVSMRYSHKRIQDWNCNKCGVCNFKFRFYCFVCKTSREDSE 369
            ||:.:        :|.|.::|:            :.:.|                   .|:|.|.
Yeast   240 EFDPI--------LTIGKVELS------------VSEGN-------------------ESKEISV 265

  Fly   370 TTFSSGSEGVDEVSTILTKKIMLRNLDALTNEEAVLTALQLHLKDLSKTVSKVLISRDSLTQASR 434
            ...:.|::.....:..::..:...:.....|:|       |..:..::..|:.|....:.::..:
Yeast   266 DVPNKGNKTYHPFAGYISNVLHGMHTSDSDNDE-------LDYEIETENNSEPLYESSASSEVDQ 323

  Fly   435 GICYL---HFDTLVDSMNVHNALTALDPPLTLDDRVVAITYCIDLE-EQQALPKNPKE-----LA 490
            |..|:   |     :|...:|.|.:..|.||.|.:.::|......| ....||....|     ..
Yeast   324 GFNYVGQRH-----NSRADNNLLPSPSPQLTEDIKCLSINGTKTFEGNNDNLPSPASEELEFGFK 383

  Fly   491 VKDSTVNSGNISAVSPSGLGGNYTLADVPRLAEYSASLYASNPAEHAYYVQYYT---EYYTADIN 552
            .:|..:|:.:| .||...:||                      .:::||::.|.   :|
Yeast   384 EEDFVINTNDI-VVSNIRMGG----------------------VDNSYYLRCYRLLGDY------ 419

  Fly   553 KNNRDSHLTEANSGAAVALSAIQRKQKKMSSIETTITAAATAAAQAAAQVKATLAAQVASA-PKG 616
                |.|..:.:......:..:...:.::.:....|              |.:|..::..| |..
Yeast   420 ----DFHWIDQDLLTDFVVDELGLPEDRLPAYLNFI--------------KNSLIPKIEPAEPTY 466

  Fly   617 NDGKIYPTPDVTQYQYDETSGYYYDSTTGLYYNAHSQYYYNNETGAYLYWDQRRSTYVLATPAST 681
            :|   .|..|.:    ||...|..||            |.::|       |...|    ...:..
Yeast   467 SD---IPISDSS----DEGDSYEGDS------------YEDDE-------DMASS----VVHSDI 501

  Fly   682 QAALQEVLADAEQKGEEESK----KAKEKEGGNKHDKVKVAKKIVKDME-------KWAKQLNQK 735
            :..|.:::|...:...|..|    |:.|.:|..|..|:.:...:..|.|       |::|::..|
Yeast   502 EEGLDDLIAYTLKHDTERFKTFETKSLETKGKGKKKKLLIDDALALDTETLETLQSKFSKRIETK 566

  Fly   736 KDYTAVATPQPILANEVATTSRGNQGGYADVGFSILEKKERGKLNDYAPNPTVGPMNKLVN---- 796
                                                .||.:.| .|:     :...|:..|
Yeast   567 ------------------------------------AKKRKAK-EDF-----IDQENRNSNDMLK 589

  Fly   797 --AYGGTSDSEEDNAAS--SQNTQSSAVVSGGGGAEESDYVDFHKLTCLLCKRAFQSLEILQKH- 856
              .||....:.:|...|  |:|               :|.:.|..|.    ....:::..:.||
Yeast   590 KYPYGLHIQNIKDEFESFLSRN---------------NDRLTFPPLD----PHGNKTVMKIAKHY 635

  Fly   857 -LKMSTLHKEN-----LAKLNQNTSSSIEEALAYRDRAKERRLKYGESDPPPPNRSRERFEQEIK 915
             :|.|.:.|.|     :.|:.:...||...:|.  |:...:|..:...|...|...:..||: .|
Yeast   636 NMKSSKIGKANHTSVVVEKIKKTKWSSPNYSLI--DQLMRQRPVFMRIDIRRPREEQAAFER-TK 697

  Fly   916 TLQSR---QKQSTSATPAMPISSSNVGSRLLQKMGWSEGQGLG-RKNQGRTQIIEADGRSNYVGL 976
            |::.:   ::.......|..|.:.|:|.|:|:|:||..|:||| :.|:|.::.|.|..:.|..||
Yeast   698 TIRGKFHVKEGEIVGQNAPEIGNENIGRRMLEKLGWKSGEGLGIQGNKGISEPIFAKIKKNRSGL 762

Fly 977 976
Yeast 763 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4887	NP_001259859.1	DUF1777	115..>196	CDD:285811	14/83 (17%)
		RRM_SF	255..335	CDD:302621	13/79 (16%)
		ZnF_RBZ	341..364	CDD:197784	1/22 (5%)
		RanBP2-type Zn finger	342..361	CDD:275375	1/18 (6%)
		RRM1_RRM2_RBM5_like	387..473	CDD:240759	16/88 (18%)
		OCRE_RBM5_like	623..678	CDD:293881	11/54 (20%)
		OCRE repeat 1	628..635	CDD:293881	1/6 (17%)
		OCRE repeat 2	636..643	CDD:293881	2/6 (33%)
		OCRE repeat 3	644..651	CDD:293881	0/6 (0%)
		OCRE repeat 4	652..659	CDD:293881	1/6 (17%)
		OCRE repeat 5	661..668	CDD:293881	0/6 (0%)
		G-patch	935..979	CDD:279867	18/43 (42%)
SQS1	NP_014175.1	R3H_G-patch	597..654	CDD:100075	13/75 (17%)
SQS1	NP_014175.1	G-patch	721..764	CDD:396249	18/42 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900