DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4887 and Rbm5

DIOPT Version :9

Sequence 1:	NP_001259859.1	Gene:	CG4887 / 33304	FlyBaseID:	FBgn0031318	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_001346454.1	Gene:	Rbm5 / 83486	MGIID:	1933204	Length:	815	Species:	Mus musculus

Alignment Length:	918	Identity:	296/918 - (32%)
Similarity:	441/918 - (48%)	Gaps:	156/918 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 SDRELNDYEYEQRSRDLDSRDRSSTDRDWYHNRSRSREHSRPWNRNNNHDDRSRSNERNTRHRDH 195
            ||:.::..|...|...:..||    |||  ...||||.....:.|::  |||     |..|:.|:
Mouse     3 SDKRVSRTERSGRYGSIIDRD----DRD--ERESRSRRRDSDYKRSS--DDR-----RGDRYDDY 54

  Fly   196 RMYNGGGSNHNRDRDRDRDREQDRERD---RDRDRDRERRGSSDYDSDEGHMRRNKYRSTTEALN 257
            |.|:      :.:|:|:| |..||..|   .|.|     .|..||..|....|.:|
Mouse    55 RDYD------SPERERER-RNSDRSEDGYHSDGD-----YGEHDYRHDISDERESK--------- 98

  Fly   258 IIIIFGLTKEMTRADI--MSELIKVNMEPACIRIIRKQGTDSSRGIAFVEFNTVEEAKQWMDITQ 320
            .|::.||...:|.:||  |.|..: ..:||.:|::::: |..|||.|||||..:::|..||:..|
Mouse    99 TIMLRGLPITITESDIREMMESFE-GPQPADVRLMKRK-TGVSRGFAFVEFYHLQDATSWMEANQ 161

  Fly   321 GVLKLNDERVSMRYSHKR--IQDWNCNKCGVCNFKFRFYCFVCKTSREDSETTFSSGSEGVDEVS 383
            ..|.:..:.::|.||:.|  .:||.||||.:.||:.|..||.|...:.|||.....|:....:..
Mouse   162 KKLVIQGKHIAMHYSNPRPKFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEVPPGTTESAQSV 226

  Fly   384 TILTKKIMLRNLDALTNEEAVLTALQLHLKDLSKTVSKVLISRDSLTQASRGICYLHFDTLVDSM 448
            ......|:|||:...|..::::|||..:   .|..|:.:.:.:|..||.:||..::...:.:|:.
Mouse   227 DYYCDTIILRNIAPHTVVDSIMTALSPY---ASLAVNNIRLIKDKQTQQNRGFAFVQLSSAMDAS 288

  Fly   449 NVHNALTALDPPLTLDDRVVAITYCIDLEEQQALPKNPKELAVKDSTVNSGNISAV------SPS 507
            .:...|.:|.|||.:|.:.:.:.:.....:...||...:   |...:|.|..|:|.      |.|
Mouse   289 QLLQILQSLHPPLKIDGKTIGVDFAKSARKDLVLPDGNR---VSAFSVASTAIAAAQWSSTQSQS 350

  Fly   508 GLGGNYTLADVPRLAEYSASLYASNPAEHAY--YVQY---YTEYYTADINKNNRDSHLTEANSGA 567
            |.||:         .:||    ...|.:..|  |.||   |.::|.........|   |.|.||.
Mouse   351 GEGGS---------VDYS----YMQPGQDGYTQYTQYSQDYQQFYQQQAGGLESD---TSATSGT 399

  Fly   568 AVAL--SAIQRKQKKMSSIETTITAAATAAAQAAAQVKATLAAQVASAPKG-NDGKIYPTPDVTQ 629
            .|..  :|:..:..::.:..:....:.|..||.:.   :|.....|::|.| ..|..|..||.:.
Mouse   400 TVTTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPST---STSTQAPAASPTGVVPGTKYAVPDTST 461

  Fly   630 YQYDETSGYYYDSTTGLYYNAHSQYYYNNETGAYLYWDQRRSTYVLATPASTQAALQEVLADAEQ 694
            |||||:||||||.||||||:.:||||||:.|..|||||..:.|||.|..||:.          :|
Mouse   462 YQYDESSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPAAEASSN----------QQ 516

  Fly   695 KGEEESKKAKEKEGGNKHDKVKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILANEVATTSRGN 759
            .|...:|:.|||:   :..|.|.|::|.||||:|||.||::|: ....:.||:  |.:....| .
Mouse   517 TGLPSTKEGKEKK---EKPKSKTAQQIAKDMERWAKSLNKQKE-NFKNSFQPV--NSLREEER-R 574

  Fly   760 QGGYADVGFSILEKK----ERGKL------NDYAPNPTVGPMNKLVNAYGGTSDSEEDNAASSQN 814
            :...||.||::.|||    ||.:|      |....||.   ...||.||.|.||:||:.....:
Mouse   575 ESAAADAGFALFEKKGALAERQQLLPELVRNGDEENPL---KRGLVAAYSGDSDNEEELVERLE- 635

  Fly   815 TQSSAVVSGGGGAEESDYVDFHKLTCLLCKRAFQSLEILQKHLKMSTLHKENL-----AKLNQNT 874
                        :||....|:.|:.||||:|.|.:.:.|.:|.::|.|||:|:     ::|::..
Mouse   636 ------------SEEEKLADWKKMACLLCRRQFPNRDALVRHQQLSDLHKQNMDIYRRSRLSEQE 688

  Fly   875 SSSI---EEALAYRDRAKERRLKYGESDPPPPNRSRE------RFEQEIKTLQSRQKQSTSATPA 930
            ..::   |..:.|||||.|||.|||..:||.|.|.::      .:||..|.
Mouse   689 LEALELREREMKYRDRAAERREKYGIPEPPEPKRKKQFDAGTVNYEQPTKD-------------- 739

  Fly   931 MPISSSNVGSRLLQKMGWSEGQGLGRKNQGRTQIIEADGRSNYVGLGNK-SGQMIPGND-YKSYI 993
             .|..||:|:::||.|||.||.|||||.||.|..|||..|....|||.| |...:.|.| ||..:
Mouse   740 -GIDHSNIGNKMLQAMGWREGSGLGRKCQGITAPIEAQVRLKGAGLGAKGSAYGLSGADSYKDAV 803

  Fly   994 KKMMKQRY 1001
            :|.|..|:
Mouse   804 RKAMFARF 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4887	NP_001259859.1	DUF1777	115..>196	CDD:285811	20/64 (31%)
		RRM_SF	255..335	CDD:302621	26/81 (32%)
		ZnF_RBZ	341..364	CDD:197784	12/22 (55%)
		RanBP2-type Zn finger	342..361	CDD:275375	10/18 (56%)
		RRM1_RRM2_RBM5_like	387..473	CDD:240759	22/85 (26%)
		OCRE_RBM5_like	623..678	CDD:293881	35/54 (65%)
		OCRE repeat 1	628..635	CDD:293881	4/6 (67%)
		OCRE repeat 2	636..643	CDD:293881	6/6 (100%)
		OCRE repeat 3	644..651	CDD:293881	5/6 (83%)
		OCRE repeat 4	652..659	CDD:293881	6/6 (100%)
		OCRE repeat 5	661..668	CDD:293881	4/6 (67%)
		G-patch	935..979	CDD:279867	25/43 (58%)
Rbm5	NP_001346454.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93		35/114 (31%)
		RRM1_RBM5	93..179	CDD:241196	30/96 (31%)
		zf-RanBP	183..210	CDD:366216	12/26 (46%)
		RanBP2-type Zn finger	185..204	CDD:275375	10/18 (56%)
		RRM2_RBM5	229..314	CDD:241199	22/87 (25%)
		Required for interaction with U2AF2. /evidence=ECO:0000250	321..809		191/557 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..468		23/88 (26%)
		Sufficient for interaction with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200. /evidence=ECO:0000250	452..535		45/95 (47%)
		OCRE_RBM5	455..510	CDD:293887	35/54 (65%)
		OCRE repeat 1	460..467	CDD:293887	4/6 (67%)
		OCRE repeat 2	468..475	CDD:293887	6/6 (100%)
		OCRE repeat 3	476..483	CDD:293887	5/6 (83%)
		OCRE repeat 4	484..491	CDD:293887	6/6 (100%)
		OCRE repeat 5	493..500	CDD:293887	4/6 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..539		12/43 (28%)
		G-patch	743..785	CDD:366717	23/41 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843023
Domainoid	1	1.000	124	1.000	Domainoid score	I5489
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2109
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55750
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	1	1.000	-	-		FOG0002462
OrthoInspector	1	1.000	-	-		mtm8864
orthoMCL	1	0.900	-	-		OOG6_102541
Panther	1	1.100	-	-	O	PTHR13948
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770