DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4887 and SUA

DIOPT Version :9

Sequence 1:	NP_001259859.1	Gene:	CG4887 / 33304	FlyBaseID:	FBgn0031318	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_001190084.1	Gene:	SUA / 824590	AraportID:	AT3G54230	Length:	1008	Species:	Arabidopsis thaliana

Alignment Length:	1152	Identity:	272/1152 - (23%)
Similarity:	426/1152 - (36%)	Gaps:	338/1152 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SFSGGSENEGGRGSDYYRSRPGSRYSRSRSRSRERNRSHGGIRHRNSRSRSRDRDRSPVFRN--- 69
            |:..|..:|.....|.|...||........:||:||      ...|..|..|.:::..:..|
plant    34 SYDDGYPDERLMRDDVYNYPPGHNTLGDLPQSRKRN------YEENYPSELRRQEKPYIDSNYAA 92

  Fly    70 DQHRGGRGGAGNGD-PDLYHSLIN-----DDYRDQDERNYNSRSNFENRQFRRHDSFDRRHRDRD 128
            |.:.....|:.||. .|..|...:     |||...| .||.|::...:|...|...:|...|..|
plant    93 DYYHDSEAGSRNGHYRDHEHERSSRYDGCDDYSCND-NNYRSKNYHHSRDDGREKDYDYTRRSYD 156

  Fly   129 GESDRELNDYEYEQRSRDLDSRDRSSTDRDWYHNRSRSRE-HSRPWNRNNNHD-------DRSRS 185
            .|.:| .:..:..::|||...|:|:|.||:|   .||.|| ..|.::|..:..       .||||
plant   157 SEYER-ASVRDGSRKSRDPQDRERNSRDREW---DSRDREWDKRCYSRERDESPHKRYEKSRSRS 217

  Fly   186 NERN--TRHRDHRMYNGGGSNHNRDRDRDRDREQDRERDRDRDRDRERRGSSDYDSDEGHMRRNK 248
            ..|.  :|.|..|     |.:|.|.. |:...|.|...:.:|.|:.|.|.:.|:
plant   218 TGRGEFSRSRSPR-----GRSHGRSY-REDSYEGDHWNESERRREYEDRHNQDH----------- 265

  Fly   249 YRSTTEALNIIIIFGLTKEMTRADIMSELIKVNMEPA-CIRIIRKQGTDSSRGIAFVEFNTVEEA 312
            :.:|..|  .:::.||:.:.|..|:..  |.....|. .:|:||:|.:..|||.||::|.||:.|
plant   266 FSATPSA--TVVVKGLSMKSTEEDLYQ--ILAEWGPLHHVRVIREQNSGISRGFAFIDFPTVDAA 326

  Fly   313 KQWMD-ITQGVLKLNDERVSMRYSHK--------RIQ------------------DWNCNKCGVC 350
            :..|| |....:.|:..::...||.:        |.|                  ||.|..||..
plant   327 RTMMDRIEHDGIVLDGRKLMFHYSSQPTGRAGVSRRQEHASRRSYGGSRNMIVPTDWICTICGCI 391

  Fly   351 NFKFRFYCFVC---KTSREDSETTFSSGSEGVDEVS-TILTKKIMLRNLDALTNEEAVLTALQLH 411
            ||..|..||.|   ||....|.....|.|.....:| |..|..:::|.||...:||.:......|
plant   392 NFARRTSCFQCNEPKTKDSPSADVGLSNSAAGKRISETGPTHVLVVRGLDEDADEEMLRYEFSKH 456

  Fly   412 --LKDLSKTVSKVLISRDSLTQASRGICYLHFDTLVDSMNVHNALTALDPPLTLDDRVVAITYCI 474
              :|||.       :.||..|..|||..::||.::.|:                       |..:
plant   457 APIKDLR-------LVRDKFTHVSRGFAFVHFYSVEDA-----------------------TKAL 491

  Fly   475 DLEEQQALPKNPKELAVKDSTVNSGNISAVSPSGLGGNYTLADVPRLAEYSASLYASNPA----E 535
            :...:.||.:|.|.|.|       ....:|..||.|             .||..:::|.|    |
plant   492 EATNRTALERNGKILRV-------AYAKSVHGSGTG-------------ISAPSHSNNLAAAAIE 536

  Fly   536 HAYYVQYY-------TEYYTADINKNNRDSHLTEANSGAAVALSAIQRKQKKMSSIETTITAAAT 593
            .|.:.|.|       .||.|.:           :.|:|
plant   537 AATFSQQYDGVGWAPKEYNTGE-----------KQNTG--------------------------- 563

  Fly   594 AAAQAAAQVKATLAAQVASAPKGNDGKIYPTPDVTQYQYDETSGYYYDSTTGLYYNAHSQYYYNN 658
            ..||...:::   :.:..|||:..            |.:||.||||||:.:|.||:.:|..||::
plant   564 GQAQGVGEIE---SQKGTSAPQSG------------YVWDEASGYYYDAASGYYYDGNSGLYYDS 613

  Fly   659 ETGAYLYWDQRRSTYVLATPASTQAALQEVLADAEQKGEEESKK--------------------- 702
            .:|.:..:||:...||.....:.::.:.|...|:.:|.:...:|
plant   614 NSGLWYSYDQQTQQYVPCPDQNNESKVTENQPDSAKKEKSSQQKVIISAATTPNVEKVLSLPDAV 678

  Fly   703 --------AKEKEGGNKHDKVKVAKK--IVKDMEKWAKQL---NQKKDYTAVATPQPILANEVAT 754
                    |.||....:..::|:|.|  ::...:|.:..|   .|:...|.:..|.|.|.:...|
plant   679 QAAAAAAIASEKREKERVKEIKLASKTSLLASKKKMSNVLTMWKQRSHETQIQRPSPSLGDNPPT 743

  Fly   755 TSRGNQGGYADVGFS-------ILEKKERGKLN---------DYAPNPTVGP--MNKLVNAYGGT 801
            .|...:..:: .|.|       ::..|||...|         :.:.:.|.|.  |..:..::|||
plant   744 VSAEARSSFS-TGQSMGKLKSDVIIAKERSTSNHGVSALTTAESSSSSTTGGTLMGVMRGSFGGT 807

  Fly   802 SDSEEDNAASSQNTQ----------SSAVVSGGGGAEESDYVDFHKLTCLLCKRAFQSLEILQKH 856
            .    ..|:||.:.|          :|..|||.|                  :|.|....
plant   808 L----GGASSSASVQMPPILPSASPASVSVSGSG------------------RRRFSETP----- 845

  Fly   857 LKMSTLHKENLAKLNQNTSSSIEEALAYRDRAKERRLKYGESDPPPPNRSRERFEQEIKTLQSRQ 921
             .....|:|             :...:|||||.|||..||.|     ..|........:.|...:
plant   846 -TAGPTHRE-------------QPQTSYRDRAAERRNLYGSS-----TSSGNDVIDSSEDLMGLR 891

  Fly   922 KQSTSATPAMP------------------------ISSSNVGSRLLQKMGWSEGQGLGRKNQGRT 962
            |.|:..||..|                        |..||||:|:|:.|||.||.|||:...|..
plant   892 KGSSDPTPFPPGVGGRGITTSTEVSSFDVITEERAIDESNVGNRMLRNMGWHEGSGLGKDGSGMK 956

  Fly   963 QIIEADGRSNYVGLGNKSG------QMIPGNDYKSYIKKMMKQRYEN 1003
            :.::|.|.....|||::..      ::.||:.|::.:.|....|:.:
plant   957 EPVQAQGVDRRAGLGSQQKKVDAEFEVQPGDTYRTLLHKKALARFRD 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4887	NP_001259859.1	DUF1777	115..>196	CDD:285811	28/90 (31%)
		RRM_SF	255..335	CDD:302621	24/81 (30%)
		ZnF_RBZ	341..364	CDD:197784	12/25 (48%)
		RanBP2-type Zn finger	342..361	CDD:275375	9/18 (50%)
		RRM1_RRM2_RBM5_like	387..473	CDD:240759	20/87 (23%)
		OCRE_RBM5_like	623..678	CDD:293881	20/54 (37%)
		OCRE repeat 1	628..635	CDD:293881	2/6 (33%)
		OCRE repeat 2	636..643	CDD:293881	6/6 (100%)
		OCRE repeat 3	644..651	CDD:293881	3/6 (50%)
		OCRE repeat 4	652..659	CDD:293881	3/6 (50%)
		OCRE repeat 5	661..668	CDD:293881	1/6 (17%)
		G-patch	935..979	CDD:279867	20/43 (47%)
SUA	NP_001190084.1	PHA02896	<74..>219	CDD:165222	42/149 (28%)
		RRM1_RRM2_RBM5_like	270..350	CDD:240759	24/83 (29%)
		ZnF_RBZ	382..405	CDD:197784	11/22 (50%)
		RanBP2-type Zn finger	383..402	CDD:275376	9/18 (50%)
		RRM1_RRM2_RBM5_like	431..511	CDD:240759	26/116 (22%)
		OCRE_SUA_like	579..631	CDD:293885	23/63 (37%)
		OCRE repeat 1	583..590	CDD:293885	2/18 (11%)
		OCRE repeat 2	591..598	CDD:293885	6/6 (100%)
		OCRE repeat 3	599..606	CDD:293885	3/6 (50%)
		OCRE repeat 4	607..614	CDD:293885	3/6 (50%)
		OCRE repeat 5	616..623	CDD:293885	1/6 (17%)
		G_patch	927..971	CDD:197727	19/43 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	49	1.000	Domainoid score	I4422
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	183	1.000	Inparanoid score	I1429
OMA	1	1.010	-	-		QHG55750
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	1	1.000	-	-		FOG0002462
OrthoInspector	1	1.000	-	-		otm3230
orthoMCL	1	0.900	-	-		OOG6_102541
Panther	1	1.100	-	-	O	PTHR13948
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1642
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840