DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4887 and Gpatch2l

DIOPT Version :9

Sequence 1:	NP_001259859.1	Gene:	CG4887 / 33304	FlyBaseID:	FBgn0031318	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_006516282.1	Gene:	Gpatch2l / 70373	MGIID:	1917623	Length:	487	Species:	Mus musculus

Alignment Length:	484	Identity:	89/484 - (18%)
Similarity:	155/484 - (32%)	Gaps:	146/484 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 QDRERDRDRDRDRERRGSSDYDSDEGHMRRN-------KYRSTTEALNIIIIFGLTKE------M 268
            |.|.:.|.| |.|:||      ||..|:..:       ...|..||         ||:      :
Mouse    34 QQRRQLRKR-RGRKRR------SDFTHLAEHACCFSEASESSLDEA---------TKDCREVAPL 82

  Fly   269 TRADIMSELIKVNMEPACIRIIRKQGTDSSRGIAFVEFNTVEEAKQWMDITQGVLKLNDERVSMR 333
            |......:.:.....||...|||.:........:|.|.......::    .:.|.::..|..:..
Mouse    83 TNFSDSDDTVVAKRHPALSAIIRGKQHSWPESDSFTENAPCRPLRR----RRKVKRVTSEVAASL 143

  Fly   334 YSHKRIQDWNCNKCGVCNFKFRFYCFVCKTSREDSETTFSSGSEGVDEVS---TILTKKIMLRNL 395
            ....::.||:..:  .|.||   .....:.||....|.::|...|:.|.:   |.|::......:
Mouse   144 QQKLKVSDWSYER--GCRFK---SAKKQRLSRWKENTPWTSSGHGLCESAENRTFLSQPGRKERM 203

  Fly   396 DALTNEEAVLTALQLHLKDLSKTVSKV---LISRDSLTQAS--------RGICYLHFDTLVDSMN 449
            :....|:...:...:...|.|...|..   |.:.|...|..        .|.|       |....
Mouse   204 ECEAEEQKHGSDENMSECDTSSVCSSSDTGLFTNDEGRQGDDEQSDWFYEGEC-------VPGFT 261

  Fly   450 VHNALTALDPPLTLDDRVVAITYCIDLEEQQA-----------LPKNP----------------- 486
            |||.|....|           .:|.::|...:           ||..|
Mouse   262 VHNLLPKWAP-----------DHCTEVERMDSGLDKLSDPTFLLPSRPAQRGYHGRLNRLPGAAA 315

  Fly   487 -------KELAVKDSTVNSGNISAVSPSGLGGNYTLADVPRLAEYSASLYASNPAEHAYYVQY-- 542
                   :.|..|:::::|.....:       .:|::| ||..|...:|.:.:|:..|...::
Mouse   316 RCLRKGRRRLPGKEASMSSLGTERI-------GHTISD-PRQTEKMRALASGSPSISACVHEFNP 372

  Fly   543 YTEYYTADINKNNRDSHLTEANSGAAVAL--------SAIQRKQKKMSS-------------IET 586
            .:..|:.|:..:......:.|:..|..|.        ..|:||:|.::|             :|.
Mouse   373 LSPLYSLDVLADASHRRCSPAHCSARQASVHWGPPCPRDIKRKRKPVASASFSSPSPVHPDVLEP 437

  Fly   587 TITA----------AATAAAQAAAQVKAT 605
            .|.|          ..:||.:|.|...||
Mouse   438 AIPAQKPPDSEWLDGTSAAEKATAFPPAT 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4887	NP_001259859.1	DUF1777	115..>196	CDD:285811
		RRM_SF	255..335	CDD:302621	13/85 (15%)
		ZnF_RBZ	341..364	CDD:197784	5/22 (23%)
		RanBP2-type Zn finger	342..361	CDD:275375	4/18 (22%)
		RRM1_RRM2_RBM5_like	387..473	CDD:240759	15/96 (16%)
		OCRE_RBM5_like	623..678	CDD:293881
		OCRE repeat 1	628..635	CDD:293881
		OCRE repeat 2	636..643	CDD:293881
		OCRE repeat 3	644..651	CDD:293881
		OCRE repeat 4	652..659	CDD:293881
		OCRE repeat 5	661..668	CDD:293881
		G-patch	935..979	CDD:279867
Gpatch2l	XP_006516282.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900