DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4887 and Rbm10

DIOPT Version :9

Sequence 1:	NP_001259859.1	Gene:	CG4887 / 33304	FlyBaseID:	FBgn0031318	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_038955950.1	Gene:	Rbm10 / 64510	RGDID:	631366	Length:	930	Species:	Rattus norvegicus

Alignment Length:	1119	Identity:	331/1119 - (29%)
Similarity:	473/1119 - (42%)	Gaps:	321/1119 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ENEGGRGSDYYRSRPGSRYSRSRSRSRERNRSHGGIRHRNSRSRSRDRDRSPVFRNDQHRGGRGG 78
            |..||||     .|.| ||.     :.:|::..||      .:||||.
  Rat     4 ERRGGRG-----DRTG-RYG-----ATDRSQDDGG------ENRSRDH----------------- 34

  Fly    79 AGNGDPDLYHSLINDDYRDQDERNYNSRSNFENRQFRRHDSFDRRHRDRDGESDRELNDYEYEQR 143
                           ||||.|.|:|                 .|.:..::|:       :||:..
  Rat    35 ---------------DYRDMDYRSY-----------------PREYGSQEGK-------HEYDDS 60

  Fly   144 SRDLDSRDRSSTDRDWYHNRSRSREHSRPWNRNNNHDDRSRSNERNTRHRDHRMYNGGGSNHNRD 208
            |.:..:.|                          :::....|..:..|.|.||....|.....||
  Rat    61 SEEQSAED--------------------------SYEASPGSETQRRRRRRHRHSPTGPPGFPRD 99

  Fly   209 ---RDRDRDREQ-DRERDRDRDRDRERRGSSDYDSDEGHMRRNKYRSTTEALNIIIIFGLTKEMT 269
               ||:|...|| :.|.:.|.:.:.|.:.|                      ||:::..|.:..|
  Rat   100 GDYRDQDYRTEQGEEEEEEDEEEEEEEKAS----------------------NIVMLRMLPQAAT 142

  Fly   270 RADIMSELIKVNMEPACIRIIRKQGTDSSRGIAFVEFNTVEEAKQWMDITQGVLKLNDERVSMRY 334
            ..||..:|....::...:|::|.:.:..|||.|||||:.:::|.:||:..|..|.:..::|||.|
  Rat   143 EDDIRGQLQSHGVQAREVRLMRNKSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHY 207

  Fly   335 SH---KRIQDWNCNKCGVCNFKFRFYCFVCKTSREDSETTFSSG--------------------- 375
            |.   |..:||.||||||.|||.|..||.|...:.::|.....|
  Rat   208 SDPKPKINEDWLCNKCGVQNFKRREKCFKCGVPKSEAEQKLPLGTRLDQQALPLGGRELSQGLLP 272

  Fly   376 ----------------SEGVDEVSTILTKKIMLRNLDALTNEEAVLTALQLHLKDLSKTVSKVLI 424
                            |:|.:..|......|:||||:..:..:::|.||..:.. ||.  |.|.:
  Rat   273 LPQPYQAQGVLTSQALSQGSEPSSENANDTIILRNLNPHSTMDSILGALAPYAV-LSS--SNVRV 334

  Fly   425 SRDSLTQASRGICYLHFDTLVDSMNVHNALTALDPPLTLDDRVVAITYCIDLEEQQALPKNPKEL 489
            .:|..||.:||..::...|:|::..:...|.||.||||:|.:.:.:.:....:...|
  Rat   335 IKDKQTQLNRGFAFIQLSTIVEAAQLLQILQALHPPLTIDGKTINVEFAKGSKRDMA-------- 391

  Fly   490 AVKDSTVNSGNIS---------AVSPSGLGGNYTLADVPRLAEYSASLYASNPAEHAYYVQ---- 541
            :.:.|.:|:.:::         |:|.:..||..|.| .|.          ..|.:::||.|
  Rat   392 SNEGSRINAASVASTAIAAAQWAISQASQGGESTWA-APE----------EPPVDYSYYQQDEGY 445

  Fly   542 --------YYTEYYTADINKNNRDSHLTEA---NSGA-----------AVALSAIQRKQ------ 578
                    .|...|.    ||.:...:|..   .|||           :|:|.|..|.|
  Rat   446 GSSQGTDSLYAHGYL----KNTKGPGMTGTKGDTSGAGPETSLEGGTDSVSLQAFSRAQPGAAPG 506

  Fly   579 -----KKMSSIETTITAAATAAAQAAAQVKATL--------AAQVASAPKGNDG-KIYPTPDVTQ 629
                 .:.||.:.|.|.:.:....:.|.:|:.|        |...|::|...:. ..||.|||:.
  Rat   507 LYQQSAEGSSGQGTATNSQSYTIMSPAVLKSELQSPTHPSSALPPATSPTAPESYSQYPVPDVST 571

  Fly   630 YQYDETSGYYYDSTTGLYYNAHSQYYYNNETGAYLYWDQRRSTYVLATPASTQAALQEVLADAEQ 694
            ||||||||||||..|||||:.:||||||.::..|||||..|.||:   ||..|:      ||..:
  Rat   572 YQYDETSGYYYDPQTGLYYDPNSQYYYNAQSQQYLYWDGERRTYI---PALEQS------ADGHK 627

  Fly   695 KGEEESKKAKEKEGGNKHDKVKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILA------NEVA 753
            .....||:.|||:  .|| |.|.|::|.||||:||:.||::|: ....:.|||.|      .|.|
  Rat   628 DTGASSKEGKEKK--EKH-KTKTAQQIAKDMERWARSLNKQKE-NFKNSFQPISALRDDERRESA 688

  Fly   754 TTSRGNQGGYADVGFSILEKK----ER-------GKL-NDYAPNPTVGPMNKLVNAYGGTSDSEE 806
            |         ||.|::|||||    ||       .|| :|..|:|..|    ||.||.|.|||||
  Rat   689 T---------ADAGYAILEKKGALAERQHTSMDLPKLASDDRPSPPRG----LVAAYSGESDSEE 740

  Fly   807 DNAASSQNTQSSAVVSGGGGAEESDYVDFHKLTCLLCKRAFQSLEILQKHLKMSTLHKENL---- 867
            :.             ..||...|....|:.||.||||:|.|.|.|.|.:|.::|.|||:||
  Rat   741 EQ-------------ERGGPEREEKLTDWQKLACLLCRRQFPSKEALIRHQQLSGLHKQNLEIHR 792

  Fly   868 -AKLNQNTSSSIE----EALAYRDRAKERRLKYGESDPPPPNRSRERFEQEIKTLQSRQKQSTSA 927
             |.|::|...::|    |.:.|||||.|||.|||..:||.|.|   |....|.|.....:|.|..
  Rat   793 RAHLSENELEALEKNDMEQMKYRDRAAERREKYGIPEPPEPKR---RKYGGISTASVDFEQPTRD 854

  Fly   928 TPAMPISSSNVGSRLLQKMGWSEGQGLGRKNQGRTQIIEADGRSNYVGLGNKSGQ--MIPGNDYK 990
                .:.|.|:|||:||.|||.||.|||||.||....|||..|....|||.:...  :.....||
  Rat   855 ----GLGSDNIGSRMLQAMGWKEGSGLGRKKQGIVTPIEAQTRVRGSGLGARGSSYGVTSTESYK 915

  Fly   991 SYIKKMMKQRYENA 1004
            ..:.|.|..|:..|
  Rat   916 ETLHKTMVTRFNEA 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4887	NP_001259859.1	DUF1777	115..>196	CDD:285811	9/80 (11%)
		RRM_SF	255..335	CDD:302621	25/79 (32%)
		ZnF_RBZ	341..364	CDD:197784	15/22 (68%)
		RanBP2-type Zn finger	342..361	CDD:275375	13/18 (72%)
		RRM1_RRM2_RBM5_like	387..473	CDD:240759	27/85 (32%)
		OCRE_RBM5_like	623..678	CDD:293881	35/54 (65%)
		OCRE repeat 1	628..635	CDD:293881	4/6 (67%)
		OCRE repeat 2	636..643	CDD:293881	6/6 (100%)
		OCRE repeat 3	644..651	CDD:293881	5/6 (83%)
		OCRE repeat 4	652..659	CDD:293881	6/6 (100%)
		OCRE repeat 5	661..668	CDD:293881	4/6 (67%)
		G-patch	935..979	CDD:279867	26/43 (60%)
Rbm10	XP_038955950.1	RRM	21..>233	CDD:223796	77/321 (24%)
		RRM1_RBM10	129..212	CDD:410147	28/104 (27%)
		ZnF_RBZ	216..240	CDD:197784	15/23 (65%)
		RanBP2-type Zn finger	218..237	CDD:275376	13/18 (72%)
		RRM2_RBM10	299..385	CDD:410148	27/88 (31%)
		OCRE_RBM10	564..627	CDD:293886	41/71 (58%)
		OCRE repeat 1	570..577	CDD:293886	4/6 (67%)
		OCRE repeat 2	578..585	CDD:293886	6/6 (100%)
		OCRE repeat 3	586..593	CDD:293886	5/6 (83%)
		OCRE repeat 4	594..600	CDD:293886	5/5 (100%)
		OCRE repeat 5	602..609	CDD:293886	3/6 (50%)
		G-patch	858..902	CDD:396249	26/43 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346525
Domainoid	1	1.000	124	1.000	Domainoid score	I5376
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31330
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2065
OMA	1	1.010	-	-		QHG55750
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	1	1.000	-	-		FOG0002462
OrthoInspector	1	1.000	-	-		mtm9109
orthoMCL	1	0.900	-	-		OOG6_102541
Panther	1	1.100	-	-	O	PTHR13948
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1642
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810