DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4887 and LOC567058

DIOPT Version :9

Sequence 1:	NP_001259859.1	Gene:	CG4887 / 33304	FlyBaseID:	FBgn0031318	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_005166176.1	Gene:	LOC567058 / 567058	-ID:	-	Length:	1393	Species:	Danio rerio

Alignment Length:	1277	Identity:	284/1277 - (22%)
Similarity:	448/1277 - (35%)	Gaps:	419/1277 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GGSENEGGRGSDYYRSRPG--SRYS-----RSRS-------------RSRERNRSHGGIRHRNSR 55
            ||:|:.|.. .|..|||.|  ..||     |.|.             ..|:...|...:|:|..
Zfish   246 GGNEDFGDM-RDRERSRMGDIDGYSMDLPPRDRPMMDFNRRGVTPPLNPRDMFESDMDMRNRMG- 308

  Fly    56 SRSRDRDRSPVFR-ND---QHRGGRGG--AGNGDPDLYHSLINDDYRDQDERNY----NSRSNFE 110
            |.|..||:.|:|. ||   ....||..  .|.|.||   .:|..|.....:|.:    :|...|.
Zfish   309 SSSNFRDQPPMFHDNDGLPMDIRGRSDIPVGRGSPD---PMIRADELTLRDREFPEPMDSPVTFR 370

  Fly   111 NRQFRRHDSFD---RRH--RDRD------GES------DRELNDYEYEQRSRDLDSRDRSS-TDR 157
            .|:   .||..   |:|  ||||      |.:      .|::.:..:....:|:|..:||. .:|
Zfish   371 GRE---SDSLSDEWRKHGVRDRDSVPPMMGRTPQRDTYQRDMQEKFFPNHGKDVDLGERSQFKER 432

  Fly   158 DWYH------------NRSRSREHSRPWNRNNNHD------------------------------ 180
            |...            |||......:.|.:|...|
Zfish   433 DRERPSAYLGKESTGFNRSEREPKHQHWEKNTPSDFPSRELGTQKPPPIQMDPTLNVQGREGEKS 497

  Fly   181 ---DRSRSNER--------------NTRHRDHRM------YNGGGSNHNRDRDRDRDREQDRER- 221
               ||....||              |:.:::|..      :.|.|       ||..|:|..||.
Zfish   498 WPVDREEKPERTAPAGGRPPYFQDKNSPNQEHHFKSNRVPFKGSG-------DRASDQEPQRESL 555

  Fly   222 ---------------DRD-RDRDRERRGSS---DYDSDEGH-----MRRNK-------------- 248
                           |:| ||.| .|.||.   ||...:.|     ::.:|
Zfish   556 MSGPKEMQSNRGEQLDQDYRDID-YRTGSGRKYDYSLGDLHGLEKDVKESKLVPVERVDDSGSQD 619

  Fly   249 --YRST---TEALNIIIIFGLTKEMTRADIMSELIKVNMEPACIRIIRKQGTDSSRGIAFVEFNT 308
              |||.   .:..|.|.|.|:.|..|...|:......:..|.....|:......|...|:|||..
Zfish   620 QDYRSAGVQDKITNTIAISGIPKNATMQQILGAFAVRDGVPMQGMKIKDVVPGYSFDTAYVEFLN 684

  Fly   309 VEEAKQWMDITQGVLKLNDERVSMRY--SHKRIQDWNCNKCGVCNFKFRFYCFVCKTS------- 364
            :|:|..:|:..||.:|:.|:...::|  |.|             |.|.:.:....|.:
Zfish   685 LEDAVHFMESNQGSVKVGDKTALLKYVQSDK-------------NGKEQLHEPPTKATPASDDGL 736

  Fly   365 --------REDSETT----FSSGSEGVDEVSTILTKKIMLRNLD--------------ALTNEEA 403
                    .:..||.    ..:.|:||.:.|:.||.:...:.:|              ..||:.|
Zfish   737 LPNPVPPPNKQEETAVKPLLDAASQGVWQRSSNLTPEAWQQQVDQQQQQQELEQQPTEEWTNQRA 801

  Fly   404 VLTALQLHLKDLSKTVSKVLISRDSLTQASRGICYLHFDTLVDSMNVHNALTALDPPLTLDDRVV 468
              :...|...|.....||.:|.::                ::.:..|...|.||||...||:|.|
Zfish   802 --SRQNLQYSDPVFKESKTMIIKN----------------ILPTTTVETILKALDPFAYLDERNV 848

  Fly   469 AIT---------YC-IDLEEQQALPK------NPKELAV-------------KDSTVNSGNISAV 504
            .:.         :| :|::..:.:.:      .|:.:.:             |:......|..|
Zfish   849 RLVKGKSPGSKCFCFVDMDSHEHVTRLVELLTKPRPIMIDGVRVYAEVAKPLKNQNYRRDNEKA- 912

  Fly   505 SPSGLGGNYTLADVPRLAEYSASLYASNPAEHAYYVQYYTEYYTADINKNNRDSHLTEANSG-AA 568
                   |.:|..:|      ..:....|.:...  |:|.:.....:...:....|..|::. ::
Zfish   913 -------NTSLLGLP------PDVIKQQPYQQPQ--QFYPQPVLTAVGAASIQGDLIGADATLSS 962

  Fly   569 VALSAIQRKQKKMSSIETTITAAATAAAQAAAQVKATLAAQVASAPKGNDGKIY--PTPDVTQYQ 631
            ||:.:....|..|.|.::.|......|.|   |..|...|.|:.|....||..|  ..||::.:.
Zfish   963 VAVPSSSLTQGVMYSNKSAIAQTVQTAEQ---QAPALSDAAVSGAADSIDGYNYGSEAPDLSAFL 1024

  Fly   632 YDETSGYYYDSTTGLYYNAHSQYYYNNETGAYLYWDQRRSTYVLATPASTQA------------- 683
            ||.|||:|||..|.|||:.:|:|:|:.:...|||||....||:....:||..
Zfish  1025 YDATSGFYYDPQTTLYYDPNSRYFYDAQNQQYLYWDSSLKTYIPVQSSSTDGQNVPEVPAPEVPA 1089

  Fly   684 -------------------ALQEVLADA---EQKGEEESKKAKEKEGGNKHDKVKVAKKIVKDME 726
                               |:.|.|.:.   |:.|:...|:.||||   :..:...|.||:||||
Zfish  1090 PVTPVAEVIAVPIKEEEAKAVSEALPEVRVEEEPGQRGEKREKEKE---EKPRSLAAFKIMKDME 1151

  Fly   727 KWAKQLNQKKDYTAVATPQPILANEVATTSRGNQGGYADVGFSILEK---------------KER 776
            :|||..|.||:  :|..|.|:|.:  ....|.::.  ||..|:|.|:               |::
Zfish  1152 RWAKIQNSKKE--SVRAPSPVLKS--GDDHRPSKA--ADAAFAIFERKTGADELFKKPLAPPKQK 1210

  Fly   777 GKLNDYAPNPTVGPMNKLVNAYGGTSDSEEDNAASSQNTQSSAVVSGGGGAEESDYVDFHKLTCL 841
            .:.:...|   :|.:..|...||..||.||:.....|.....|........:|....|:.|:.||
Zfish  1211 DEKSSKRP---MGSLGMLAADYGAGSDEEEEEKHDKQEASRPAKSQPQADEKEDRLTDWKKMACL 1272

  Fly   842 LCKRAFQSLEILQKHLKMSTLHKENLAKLNQNTSSSIEEALAYRDRAKERRLKYGESDPPPPNRS 906
            ||:|.|.:.:.|.:|.::|.|||:|:                      |..||.
Zfish  1273 LCRRQFPNKDALIRHQQLSDLHKQNM----------------------EIHLKI----------- 1304

  Fly   907 RERFEQEIKTLQSRQKQSTSATPAMPISSSNVGSRLLQKMGW----------SEGQGLGRKNQGR 961
             :|.::|::.|::::|:..:..|    .||....|...:..|          ||..|||.:...|
Zfish  1305 -KRSKRELEALENQEKEMKTKAP----GSSPEAKRRKPQNTWAGSSRDSFKGSERPGLGLETTER 1364

  Fly   962 TQIIEADGRSNYVGLGNKSGQMIPGN--DYKSYIKKMMKQRY 1001
                             |..:.:..|  .||..::|.|..|:
Zfish  1365 -----------------KKKEPVVWNHATYKQAVRKAMFARF 1389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4887	NP_001259859.1	DUF1777	115..>196	CDD:285811	27/157 (17%)
		RRM_SF	255..335	CDD:302621	22/81 (27%)
		ZnF_RBZ	341..364	CDD:197784	3/22 (14%)
		RanBP2-type Zn finger	342..361	CDD:275375	2/18 (11%)
		RRM1_RRM2_RBM5_like	387..473	CDD:240759	20/108 (19%)
		OCRE_RBM5_like	623..678	CDD:293881	24/54 (44%)
		OCRE repeat 1	628..635	CDD:293881	2/6 (33%)
		OCRE repeat 2	636..643	CDD:293881	5/6 (83%)
		OCRE repeat 3	644..651	CDD:293881	4/6 (67%)
		OCRE repeat 4	652..659	CDD:293881	3/6 (50%)
		OCRE repeat 5	661..668	CDD:293881	4/6 (67%)
		G-patch	935..979	CDD:279867	10/53 (19%)
LOC567058	XP_005166176.1	RRM_SF	633..710	CDD:302621	21/76 (28%)
		RRM_SF	815..899	CDD:302621	16/99 (16%)
		OCRE_RBM5_like	1017..1070	CDD:293881	24/52 (46%)
		OCRE repeat 1	1021..1028	CDD:293881	2/6 (33%)
		OCRE repeat 2	1029..1036	CDD:293881	5/6 (83%)
		OCRE repeat 3	1037..1044	CDD:293881	4/6 (67%)
		OCRE repeat 4	1045..1052	CDD:293881	3/6 (50%)
		OCRE repeat 5	1054..1061	CDD:293881	4/6 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587908
Domainoid	1	1.000	116	1.000	Domainoid score	I5905
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13948
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.810