DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4887 and CG4896

DIOPT Version :9

Sequence 1:	NP_001259859.1	Gene:	CG4887 / 33304	FlyBaseID:	FBgn0031318	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_608583.5	Gene:	CG4896 / 33305	FlyBaseID:	FBgn0031319	Length:	949	Species:	Drosophila melanogaster

Alignment Length:	1024	Identity:	645/1024 - (62%)
Similarity:	746/1024 - (72%)	Gaps:	95/1024 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSSSRRSFSGGSENEGGRGSDY-YRSRPGSRYSRSRSRSRERNRSHGGIRHRNSRSRSRDRDRS 64
            |||....|||||:    |.||:. ||     ||||||||||||:|.....|.|||||||  |:||
  Fly     1 MDSRYGHSFSGGN----GNGSESGYR-----RYSRSRSRSRERSRDRNEYRRRNSRSRS--RERS 54

  Fly    65 PVFRNDQHRGGRGGAGNGDPDLYHSLINDDYRDQDERNYNSRSNFENRQFRRHDSFDRRHRDRDG 129
            ..:|||:         :.|.|||..|||:||.||.  |||||.|.:.|  ...|.:||||.|..|
  Fly    55 SHYRNDR---------SPDRDLYRDLINEDYEDQG--NYNSRQNLDQR--HGEDKYDRRHADSQG 106

  Fly   130 ESDRELNDYEYEQRSRDLDSRDRSSTDRDW--YHNRSRSREHSRPWNRNNNHDDRSRSNERNTRH 192
            ..|.:.|   |::..:|:| :||   |..|  |...||.|          ||||..|.:||::|.
  Fly   107 RRDHDSN---YDKSGQDMD-KDR---DHRWKNYDRVSRER----------NHDDFDRGSERSSRS 154

  Fly   193 RDHRMYNGGGSNHNRDRDRDRDREQDRERDRDRDRDRERRGSSDYDSD--EGHMRRNKYR--STT 253
            .|.|.:|..|::::....|||::|          |||:||.|||.|||  ....:|..|.  |:.
  Fly   155 NDQRQFNNNGNSNSSSSYRDREKE----------RDRDRRCSSDEDSDMASEFRQRGAYNSGSSV 209

  Fly   254 EALNIIIIFGLTKEMTRADIMSELIKVNMEPACIRIIRKQGTDSSRGIAFVEFNTVEEAKQWMDI 318
            |.||.||:|||.|.:|.||||.|||||::||..||::|||.|.:||..|||||.|||||.:||::
  Fly   210 EPLNNIILFGLKKHVTEADIMGELIKVDLEPTSIRVMRKQQTGASRCFAFVEFKTVEEATRWMEL 274

  Fly   319 TQGVLKLNDERVSMRYSHKRIQDWNCNKCGVCNFKFRFYCFVCKTSREDSETTFSSGSEGVDEVS 383
            |||||:|.|.||:|:|||.||.||.|.|||..|||.||.|::|..||.:||.......|||||:|
  Fly   275 TQGVLQLGDHRVTMQYSHTRISDWTCIKCGASNFKRRFQCYMCNASRAESENALYGAGEGVDEIS 339

  Fly   384 TILTKKIMLRNLDALTNEEAVLTALQLHLKDLSKTVSKVLISRDSLTQASRGICYLHFDTLVDSM 448
            .|||||||||.||||||||.||||||..|.:|:|||||||:|||:||.||||||||:||||:|||
  Fly   340 QILTKKIMLRGLDALTNEEGVLTALQQRLPELAKTVSKVLVSRDALTNASRGICYLNFDTLIDSM 404

  Fly   449 NVHNALTALDPPLTLDDRVVAITYCIDLEEQQALPKNPKELAVKDSTVNSGNI-----SAVSPSG 508
            ||.|.||||||||||||:.|.:|||||.|.:|.:|.             .||.     :|:|||.
  Fly   405 NVFNGLTALDPPLTLDDKTVIVTYCIDSENRQMMPA-------------EGNFFRAGETAMSPSA 456

  Fly   509 LGGNYTLADVPRLAEYSASLYASNPAEHAYYVQYYTEYYTADINKNNRDSHLTEANSGAAVALSA 573
            :...|||||||||||||||:|||||.|||.||||||:|||.:|:||.||..:|||||||||||||
  Fly   457 ITAAYTLADVPRLAEYSASVYASNPLEHANYVQYYTDYYTTEISKNCRDRQVTEANSGAAVALSA 521

  Fly   574 IQRKQKKMSSIETTITAAATAAAQAAAQVKATLAAQVASAPKGNDGKIYPTPDVTQYQYDETSGY 638
            |||||:|:|.:|||:         :..:.|....|:..|||||||||.|.||||::|||||||||
  Fly   522 IQRKQRKVSQMETTV---------SVTEAKVAFLARGESAPKGNDGKKYDTPDVSKYQYDETSGY 577

  Fly   639 YYDSTTGLYYNAHSQYYYNNETGAYLYWDQRRSTYVLATPASTQAALQEVLADAEQKGEEESKKA 703
            |||..|||||:|||||||||||||||||||:||||||||||||||||:|||||||:| |||:|||
  Fly   578 YYDHVTGLYYDAHSQYYYNNETGAYLYWDQKRSTYVLATPASTQAALKEVLADAEKK-EEEAKKA 641

  Fly   704 KEK-----EGGNKHDKVKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILAN-EVATTSRGNQGG 762
            |||     |.|.|.||||||||||||||||||||||||||||||||||||:: |.|||||.:||.
  Fly   642 KEKEKEKEEAGGKPDKVKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILSDTEAATTSRASQGA 706

  Fly   763 YADVGFSILEKKERGKLNDYAPNPTVGPMNKLVNAYGGTSDSEEDNAASSQNTQSSAVVSGGGGA 827
            |||||||||||||.||||||.|......::|||.||||.||||:||:| :|....::|.:....:
  Fly   707 YADVGFSILEKKELGKLNDYVPEAGPPAISKLVGAYGGPSDSEDDNSA-NQKALEASVGTKRAIS 770

  Fly   828 EESDYVDFHKLTCLLCKRAFQSLEILQKHLKMSTLHKENLAKLNQN--TSSSIEEALAYRDRAKE 890
            :|||||||.|||||||.||||||:|||||||||.||||||.||.:|  ..:..:|.|:|||||||
  Fly   771 DESDYVDFQKLTCLLCMRAFQSLDILQKHLKMSNLHKENLDKLKRNPAVEAGTDEGLSYRDRAKE 835

  Fly   891 RRLKYGESDPPPPNRSRERFEQEIKTLQSRQKQSTSATPAMPISSSNVGSRLLQKMGWSEGQGLG 955
            ||||||||||||||||||||||||||||||||.|..||.||||||:||||||:||||||||||||
  Fly   836 RRLKYGESDPPPPNRSRERFEQEIKTLQSRQKDSFGATAAMPISSTNVGSRLMQKMGWSEGQGLG 900

  Fly   956 RKNQGRTQIIEADGRSNYVGLGNKSGQMIPGNDYKSYIKKMMKQRYENA 1004
            :||||||:|||||||||.|||||.:|.|.||||||||||||||||||||
  Fly   901 KKNQGRTEIIEADGRSNNVGLGNNTGHMAPGNDYKSYIKKMMKQRYENA 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4887	NP_001259859.1	DUF1777	115..>196	CDD:285811	29/82 (35%)
		RRM_SF	255..335	CDD:302621	50/79 (63%)
		ZnF_RBZ	341..364	CDD:197784	13/22 (59%)
		RanBP2-type Zn finger	342..361	CDD:275375	11/18 (61%)
		RRM1_RRM2_RBM5_like	387..473	CDD:240759	67/85 (79%)
		OCRE_RBM5_like	623..678	CDD:293881	47/54 (87%)
		OCRE repeat 1	628..635	CDD:293881	4/6 (67%)
		OCRE repeat 2	636..643	CDD:293881	6/6 (100%)
		OCRE repeat 3	644..651	CDD:293881	5/6 (83%)
		OCRE repeat 4	652..659	CDD:293881	6/6 (100%)
		OCRE repeat 5	661..668	CDD:293881	6/6 (100%)
		G-patch	935..979	CDD:279867	38/43 (88%)
CG4896	NP_608583.5	DUF1777	91..>158	CDD:285811	30/85 (35%)
		RRM1_RBM5_like	211..291	CDD:241005	50/79 (63%)
		ZnF_RBZ	296..320	CDD:197784	13/23 (57%)
		RanBP2-type Zn finger	298..317	CDD:275376	11/18 (61%)
		RRM1_RRM2_RBM5_like	343..429	CDD:240759	67/85 (79%)
		OCRE_RBM5_like	562..617	CDD:293881	47/54 (87%)
		OCRE repeat 1	567..574	CDD:293881	4/6 (67%)
		OCRE repeat 2	575..582	CDD:293881	6/6 (100%)
		OCRE repeat 3	583..590	CDD:293881	5/6 (83%)
		OCRE repeat 4	591..598	CDD:293881	6/6 (100%)
		OCRE repeat 5	600..607	CDD:293881	6/6 (100%)
		G-patch	882..922	CDD:279867	35/39 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473072
Domainoid	1	1.000	49	1.000	Domainoid score	I4422
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31330
Inparanoid	1	1.050	183	1.000	Inparanoid score	I1429
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55750
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	1	1.000	-	-		FOG0002462
OrthoInspector	1	1.000	-	-		mtm6537
orthoMCL	1	0.900	-	-		OOG6_102541
Panther	1	1.100	-	-	P	PTHR13948
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1642
	12	11.910