DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4887 and rbm5

DIOPT Version :10

Sequence 1:NP_608582.2 Gene:CG4887 / 33304 FlyBaseID:FBgn0031318 Length:1004 Species:Drosophila melanogaster
Sequence 2:NP_001093608.3 Gene:rbm5 / 324302 ZFINID:ZDB-GENE-030131-3022 Length:835 Species:Danio rerio


Alignment Length:899 Identity:276/899 - (30%)
Similarity:426/899 - (47%) Gaps:136/899 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   164 SRSREHSRPWNRNNNHDDRSRSNERNTRHRDHRMYNGGGSNHNRDRDR------------DRDRE 216
            ||:....|..:..:..|||     |:.|.||.|.|:....:.:|..||            ||...
Zfish     8 SRTERSGRYGSEQSRDDDR-----RDRRDRDDRGYDSHRWSDDRRSDRYDGDRGDRGDRGDRGDR 67

  Fly   217 QDRERDRDR-DRDRERR---GSSDYDSDEGHMRRNKYR---STTEALNIIIIFGLTKEMTRADIM 274
            .||...||. :|.|:||   ||.|....:|....:.||   :..:....|::.||....:.|||.
Zfish    68 GDRYWSRDSPERGRKRRNSDGSEDGHHSDGDYSEHDYRGDPADEKESKTIMLRGLPMNTSEADIR 132

  Fly   275 SEL-IKVNMEPACIRIIRKQGTDSSRGIAFVEFNTVEEAKQWMDITQGVLKLNDERVSMRYSHKR 338
            :.: :....:|..:|:::|: |..|||.|||||..::.|.:||:..|.:|.:..:.|.:.||:.|
Zfish   133 AAIDLLEGPKPMDVRLMKKR-TGISRGFAFVEFYHLQAATRWMETNQKLLCVQGKPVVVHYSNNR 196

  Fly   339 --IQDWNCNKCGVCNFKFRFYCFVCKTSREDSETTFSSGSEGVDEVSTILTKKIMLRNLDALTNE 401
              .:||.||.||:.||:.|..||.|..::.|||::.::|:.............|:|||:..|:..
Zfish   197 HKFEDWLCNSCGLYNFRRRLKCFRCGAAKADSESSSTTGTTETQPSGDYYGDTIILRNIAPLSTV 261

  Fly   402 EAVLTALQLHLKDLSKTVSKVLISRDSLTQASRGICYLHFDTLVDSMNVHNALTALDPPLTLDDR 466
            ||:|.||......|.   ..:.:.:|..|..:||..::...:.:::..:...|..|.|||.||.:
Zfish   262 EAILGALAPFANLLP---GNIRLIKDKQTGQNRGFAFVQLASPLEASQLLTILQGLQPPLKLDGK 323

  Fly   467 VVAITYCIDLEEQQALPKNPK--ELAVKDSTVNSGNISAVSPSGLGGNYTLADVPRLAEYSASLY 529
            .:.:.|.....:...||...:  ..:|..:.:.:...|:..|..:        |...:|||....
Zfish   324 TIGVDYAKSARKDLLLPDGNRVSAFSVASTAIAAAQWSSSQPQQI--------VEPTSEYSYLQE 380

  Fly   530 ASNPAEHAYYVQYYTEYYTADINKNN------RDSHLTEANSGAAVALSAIQRKQKKMSSIE--- 585
            ...|....|...|..:....|.:..|      ....:..|.:|..::.||...:..:.:.||   
Zfish   381 GYVPCSQEYQAYYQQQAGAVDPSLANGILGAAPGVKVVPAATGVVISQSAQVYQSPQAAQIEGKA 445

  Fly   586 TTITAAATAAAQAAAQVKATLAAQVASAPKGNDGKIYPTPDVTQYQYDETSGYYYDSTTGLYYNA 650
            ..|||.||.:|.|.:.|.||  |...|..:.|...:   ||.:.|||||:||||||..|||||:.
Zfish   446 QCITATATISAPATSAVSAT--ATATSTSQENQANV---PDTSSYQYDESSGYYYDPITGLYYDP 505

  Fly   651 HSQYYYNNETGAYLYWDQRRSTYVLATPASTQAALQEVLADAEQKGEEESKKAKEKEGGNKHDKV 715
            ::|||||::|..|||||..:..|:.|..::.|.|:.     :....::|.|:.|||      .|.
Zfish   506 NTQYYYNSQTQQYLYWDGEKQAYLPAVDSNAQNAMA-----STSTPQKEGKEKKEK------PKS 559

  Fly   716 KVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILANEVATTSRGNQGGYADVGFSILEKK------ 774
            |.|::|.||||:|||.||::|: ...::.|||...|      ..:...||.||::.|||      
Zfish   560 KTAQQIAKDMERWAKSLNKQKE-NFKSSFQPISQEE------RREAAAADAGFTLFEKKPGALER 617

  Fly   775 ---ERGKL-NDYAPNPTVGPMNKLVNAYGGTSDSEEDNAASSQNTQSSAVVSGGGGAEESDYVDF 835
               |..|: .:.:.:..||    ||.||.|.|:.||             ::.|..  .|....|:
Zfish   618 LVTEASKMAEEESCSSKVG----LVAAYSGDSEPEE-------------LIDGDD--REDKLTDW 663

  Fly   836 HKLTCLLCKRAFQSLEILQKHLKMSTLHKENL-----AKLNQNTSSSIEE---ALAYRDRAKERR 892
            .||.||||:|.|.|.|.|.:|.::|.||::||     :||::.....:|.   .:.|||||.|||
Zfish   664 KKLACLLCRRQFPSKEALIRHQQLSDLHRQNLEVMRRSKLSEAELEELERKETEMKYRDRAAERR 728

  Fly   893 LKYGESDPPPPNRSRERFEQEIKTLQSRQKQSTSATPAM--------PISSSNVGSRLLQKMGWS 949
            .|||..:||.|                ::::.|:.||.:        .::|.|:|:::||.|||.
Zfish   729 EKYGIPEPPVP----------------KKRKYTAPTPVVNYEQPTKDGLNSDNIGNKMLQAMGWK 777

  Fly   950 EGQGLGRKNQGRTQIIEADGRSNYVGLGNK--SGQMIPGNDYKSYIKKMMKQRY 1001
            ||:||||..||.|..|||..|:...|||.|  |..:...:.||..::|.|..|:
Zfish   778 EGKGLGRNQQGITTPIEAQLRAKGAGLGTKGSSYNLTASDTYKDAVRKAMFARF 831

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4887NP_608582.2 U2AF_lg 93..>193 CDD:273727 8/28 (29%)
RRM_SF 255..335 CDD:473069 24/80 (30%)
ZnF_RBZ 341..364 CDD:197784 12/22 (55%)
RanBP2-type Zn finger 342..361 CDD:275377 10/18 (56%)
RRM1_RRM2_RBM5_like 387..473 CDD:409752 22/85 (26%)
OCRE_RBM5_like 623..678 CDD:293881 31/54 (57%)
OCRE repeat 1 628..635 CDD:293881 4/6 (67%)
OCRE repeat 2 636..643 CDD:293881 6/6 (100%)
OCRE repeat 3 644..651 CDD:293881 5/6 (83%)
OCRE repeat 4 652..659 CDD:293881 5/6 (83%)
OCRE repeat 5 661..668 CDD:293881 4/6 (67%)
G-patch 935..979 CDD:396249 24/43 (56%)
rbm5NP_001093608.3 RRM1_RBM5 110..196 CDD:410146 26/86 (30%)
zf-RanBP 198..225 CDD:395516 12/26 (46%)
RanBP2-type Zn finger 202..221 CDD:275376 10/18 (56%)
RRM2_RBM5 246..331 CDD:410149 23/87 (26%)
OCRE_RBM5 478..533 CDD:293887 31/57 (54%)
OCRE repeat 1 483..490 CDD:293887 4/6 (67%)
OCRE repeat 2 491..498 CDD:293887 6/6 (100%)
OCRE repeat 3 499..506 CDD:293887 5/6 (83%)
OCRE repeat 4 507..514 CDD:293887 5/6 (83%)
OCRE repeat 5 516..523 CDD:293887 4/6 (67%)
G-patch 763..807 CDD:396249 24/43 (56%)

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