DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4887 and Rbm5

DIOPT Version :9

Sequence 1:	NP_001259859.1	Gene:	CG4887 / 33304	FlyBaseID:	FBgn0031318	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_001094018.1	Gene:	Rbm5 / 300996	RGDID:	1305059	Length:	815	Species:	Rattus norvegicus

Alignment Length:	919	Identity:	298/919 - (32%)
Similarity:	443/919 - (48%)	Gaps:	158/919 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 SDRELNDYEYEQRSRDLDSRDRSSTDRDWYHNRSRSREHSRPWNRNNNHDDRSRSNERNTRHRDH 195
            ||:.::..|...|...:..||    |||  ...||||.....:.|::  |||     |..|:.|:
  Rat     3 SDKRVSRTERSGRYGSIIDRD----DRD--ERESRSRRRDSDYKRSS--DDR-----RGDRYDDY 54

  Fly   196 RMYNGGGSNHNRDRDRDRDREQDRERD---RDRDRDRERRGSSDYDSDEGHMRRNKYRSTTEALN 257
            |.|:      :.:|:|:| |..||..|   .|.|     .|..||..|....|.:|
  Rat    55 RDYD------SPERERER-RNSDRSEDGYHSDGD-----YGEHDYRHDISDERESK--------- 98

  Fly   258 IIIIFGLTKEMTRADI--MSELIKVNMEPACIRIIRKQGTDSSRGIAFVEFNTVEEAKQWMDITQ 320
            .|::.||...:|.:||  |.|..: ..:||.:|::::: |..|||.|||||..:::|..||:..|
  Rat    99 TIMLRGLPITITESDIREMMESFE-GPQPADVRLMKRK-TGVSRGFAFVEFYHLQDATSWMEANQ 161

  Fly   321 GVLKLNDERVSMRYSHKR--IQDWNCNKCGVCNFKFRFYCFVCKTSREDSETTFSSG-SEGVDEV 382
            ..|.:..:.::|.||:.|  .:||.||||.:.||:.|..||.|...:.|||.....| :|.|..|
  Rat   162 KKLVIQGKHIAMHYSNPRPKFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEVPPGTTESVQSV 226

  Fly   383 STILTKKIMLRNLDALTNEEAVLTALQLHLKDLSKTVSKVLISRDSLTQASRGICYLHFDTLVDS 447
            . .....|:|||:...|..::::|||..:   .|..|:.:.:.:|..||.:||..::...:.:|:
  Rat   227 D-YYCDTIILRNIAPHTVVDSIMTALSPY---ASLAVNNIRLIKDKQTQQNRGFAFVQLSSAMDA 287

  Fly   448 MNVHNALTALDPPLTLDDRVVAITYCIDLEEQQALPKNPKELAVKDSTVNSGNISAV------SP 506
            ..:...|.:|.|||.:|.:.:.:.:.....:...||...:   |...:|.|..|:|.      |.
  Rat   288 SQLLQILQSLHPPLKIDGKTIGVDFAKSARKDLVLPDGNR---VSAFSVASTAIAAAQWSSTQSQ 349

  Fly   507 SGLGGNYTLADVPRLAEYSASLYASNPAEHAY--YVQY---YTEYYTADINKNNRDSHLTEANSG 566
            ||.|||         .:||    ...|.:..|  |.||   |.::|.........|:   .|.||
  Rat   350 SGEGGN---------VDYS----YMQPGQDGYTQYTQYSQDYQQFYQQQTGGLESDA---SATSG 398

  Fly   567 AAVAL--SAIQRKQKKMSSIETTITAAATAAAQAAAQVKATLAAQVASAPKG-NDGKIYPTPDVT 628
            ..|..  :|:..:..::.:..:....:.|..||.:.   :|.....|::|.| ..|..|..||.:
  Rat   399 TTVTTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPST---STSTQAPAASPTGVVPGTKYAVPDTS 460

  Fly   629 QYQYDETSGYYYDSTTGLYYNAHSQYYYNNETGAYLYWDQRRSTYVLATPASTQAALQEVLADAE 693
            .|||||:||||||.||||||:.:||||||:.|..|||||..:.|||.|..:|:.          :
  Rat   461 TYQYDESSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPAAESSSN----------Q 515

  Fly   694 QKGEEESKKAKEKEGGNKHDKVKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILANEVATTSRG 758
            |.|...:|:.|||:   :..|.|.|::|.||||:|||.||::|: ....:.||:  |.:....|
  Rat   516 QAGLPSTKEGKEKK---EKPKSKTAQQIAKDMERWAKSLNKQKE-NFKNSFQPV--NSLREEER- 573

  Fly   759 NQGGYADVGFSILEKK----ERGKL------NDYAPNPTVGPMNKLVNAYGGTSDSEEDNAASSQ 813
            .:...||.||::.|||    ||.:|      |....||.   ...||.||.|.||:||:.....:
  Rat   574 RESAAADAGFALFEKKGALAERQQLIPELVRNGDEENPL---KRGLVAAYSGDSDNEEELVERLE 635

  Fly   814 NTQSSAVVSGGGGAEESDYVDFHKLTCLLCKRAFQSLEILQKHLKMSTLHKENL-----AKLNQN 873
                         :||....|:.|:.||||:|.|.:.:.|.:|.::|.|||:|:     ::|::.
  Rat   636 -------------SEEEKLADWKKMACLLCRRQFPNRDALVRHQQLSDLHKQNMDIYRRSRLSEQ 687

  Fly   874 TSSSI---EEALAYRDRAKERRLKYGESDPPPPNRSRE------RFEQEIKTLQSRQKQSTSATP 929
            ...::   |..:.|||||.|||.|||..:||.|.|.::      .:||..|.
  Rat   688 ELEALELREREMKYRDRAAERREKYGIPEPPEPKRKKQFDAGTVNYEQPTKD------------- 739

  Fly   930 AMPISSSNVGSRLLQKMGWSEGQGLGRKNQGRTQIIEADGRSNYVGLGNK-SGQMIPGND-YKSY 992
              .|..||:|:::||.|||.||.|||||.||.|..|||..|....|||.| |...:.|.| ||..
  Rat   740 --GIDHSNIGNKMLQAMGWREGSGLGRKCQGITAPIEAQVRLKGAGLGAKGSAYGLSGADSYKDA 802

  Fly   993 IKKMMKQRY 1001
            ::|.|..|:
  Rat   803 VRKAMFARF 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4887	NP_001259859.1	DUF1777	115..>196	CDD:285811	20/64 (31%)
		RRM_SF	255..335	CDD:302621	26/81 (32%)
		ZnF_RBZ	341..364	CDD:197784	12/22 (55%)
		RanBP2-type Zn finger	342..361	CDD:275375	10/18 (56%)
		RRM1_RRM2_RBM5_like	387..473	CDD:240759	22/85 (26%)
		OCRE_RBM5_like	623..678	CDD:293881	35/54 (65%)
		OCRE repeat 1	628..635	CDD:293881	4/6 (67%)
		OCRE repeat 2	636..643	CDD:293881	6/6 (100%)
		OCRE repeat 3	644..651	CDD:293881	5/6 (83%)
		OCRE repeat 4	652..659	CDD:293881	6/6 (100%)
		OCRE repeat 5	661..668	CDD:293881	4/6 (67%)
		G-patch	935..979	CDD:279867	25/43 (58%)
Rbm5	NP_001094018.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93		35/114 (31%)
		RRM1_RBM5	93..179	CDD:410146	30/96 (31%)
		zf-RanBP	181..210	CDD:395516	12/28 (43%)
		RanBP2-type Zn finger	185..204	CDD:275375	10/18 (56%)
		RRM2_RBM5	229..314	CDD:410149	22/87 (25%)
		Required for interaction with U2AF2. /evidence=ECO:0000250	321..809		190/557 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..468		17/63 (27%)
		Sufficient for interaction with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200. /evidence=ECO:0000250	452..535		44/95 (46%)
		OCRE_RBM5	455..510	CDD:293887	35/54 (65%)
		OCRE repeat 1	460..467	CDD:293887	4/6 (67%)
		OCRE repeat 2	468..475	CDD:293887	6/6 (100%)
		OCRE repeat 3	476..483	CDD:293887	5/6 (83%)
		OCRE repeat 4	484..490	CDD:293887	5/5 (100%)
		OCRE repeat 5	492..499	CDD:293887	4/6 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..540		11/44 (25%)
		G-patch	743..787	CDD:396249	25/43 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346527
Domainoid	1	1.000	124	1.000	Domainoid score	I5376
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2065
OMA	1	1.010	-	-		QHG55750
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	1	1.000	-	-		FOG0002462
OrthoInspector	1	1.000	-	-		mtm9109
orthoMCL	1	0.900	-	-		OOG6_102541
Panther	1	1.100	-	-	O	PTHR13948
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1642
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770