DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4887 and Rbm10

DIOPT Version :9

Sequence 1:	NP_001259859.1	Gene:	CG4887 / 33304	FlyBaseID:	FBgn0031318	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_663602.1	Gene:	Rbm10 / 236732	MGIID:	2384310	Length:	930	Species:	Mus musculus

Alignment Length:	1026	Identity:	326/1026 - (31%)
Similarity:	463/1026 - (45%)	Gaps:	237/1026 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 RRHDSFDRRHRDRDGESDRELNDYEYEQRSRDLDSRDRSSTDRDWYHNRSRSREHSRPWNRNNNH 179
            ||....||  ..|.|.:||..:| ..|.||||.|.|     |.|:   ||..||:.....: :.:
Mouse     5 RRGGRGDR--TGRYGATDRSQDD-SGENRSRDHDYR-----DMDY---RSYPREYGSQEGK-HEY 57

  Fly   180 DDRSR-------------SNERNTRHRDHRMYNGGGSNHNRD---RDRDRDREQDRERDRDRDRD 228
            ||.|.             |..:..|.|.||....|.....||   ||:|...||..|.:.:.:.:
Mouse    58 DDSSEEQSAEDSYEASPGSETQRRRRRRHRHSPTGPPGFPRDGDYRDQDYRTEQGEEEEEEDEEE 122

  Fly   229 RERRGSSDYDSDEGHMRRNKYRSTTEALNIIIIFGLTKEMTRADIMSELIKVNMEPACIRIIRKQ 293
            .|.:.|                      ||:::..|.:..|..||..:|....::...:|::|.:
Mouse   123 EEEKAS----------------------NIVMLRMLPQAATEDDIRGQLQSHGVQAREVRLMRNK 165

  Fly   294 GTDSSRGIAFVEFNTVEEAKQWMDITQGVLKLNDERVSMRYSH---KRIQDWNCNKCGVCNFKFR 355
            .:..|||.|||||:.:::|.:||:..|..|.:..::|||.||.   |..:||.||||||.|||.|
Mouse   166 SSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWLCNKCGVQNFKRR 230

  Fly   356 FYCFVCKTSREDSETTFSSG-------------------------------------SEGVDEVS 383
            ..||.|...:.::|.....|                                     |:|.:..|
Mouse   231 EKCFKCGVPKSEAEQKLPLGTRLDQQALPLGGRELSQGLLPLPQPYQAQGVLTSQALSQGSEPSS 295

  Fly   384 TILTKKIMLRNLDALTNEEAVLTALQLHLKDLSKTVSKVLISRDSLTQASRGICYLHFDTLVDSM 448
            ......|:||||:..:..:::|.||..:.. ||.  |.|.:.:|..||.:||..::...|:|::.
Mouse   296 ENANDTIILRNLNPHSTMDSILGALAPYAV-LSS--SNVRVIKDKQTQLNRGFAFIQLSTIVEAA 357

  Fly   449 NVHNALTALDPPLTLDDRVVAITYCIDLEEQQALPKNPKELAVKDSTVNSG---NISAVSPSGL- 509
            .:...|.||.||||:|.:.:.:.:.          |..|    :|...|.|   |.::|:.:.:
Mouse   358 QLLQILQALHPPLTIDGKTINVEFA----------KGSK----RDMASNEGSRINAASVASTAIA 408

  Fly   510 GGNYTLADVPRLAEYSASLYASNPAEHAYYVQ------------YYTEYYTADINKNNRDSHLT- 561
            ...:.::...:..|.:.:.....|.:::||.|            .|...|.    ||::...:|
Mouse   409 AAQWAISQASQGGESAWAAPEEPPVDYSYYQQDEGYGSSQGTDSLYAHGYL----KNSKGPGMTG 469

  Fly   562 ----------EAN--SGA-AVALSAIQRKQ-----------KKMSSIETTITAAATAAAQAAAQV 602
                      ||:  :|| :|:|.|..|.|           .:.||.::|.|.:.:....:.|.:
Mouse   470 TKGDPAGTGPEASLEAGADSVSLQAFSRAQPGAAPGLYQQSAEGSSGQSTATNSQSYTIISPAVL 534

  Fly   603 KATL---------AAQVASAPKGNDG-KIYPTPDVTQYQYDETSGYYYDSTTGLYYNAHSQYYYN 657
            ||.|         |...|::|...:. ..||.|||:.||||||||||||..|||||:.:||||||
Mouse   535 KAELQSPTQPSSSAFPPATSPTAPEAYSQYPVPDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYN 599

  Fly   658 NETGAYLYWDQRRSTYVLATPASTQAALQEVLADAEQKGEEESKKAKEKEGGNKHDKVKVAKKIV 722
            .::..|||||..|.||:   ||..|:      ||..:.....||:.|||:  .|| |.|.|::|.
Mouse   600 AQSQQYLYWDGERRTYI---PALEQS------ADGHKDTGASSKEGKEKK--EKH-KTKTAQQIA 652

  Fly   723 KDMEKWAKQLNQKKDYTAVATPQPILA------NEVATTSRGNQGGYADVGFSILEKK----ER- 776
            ||||:||:.||::|: ....:.|||.|      .|.||         ||.|::|||||    ||
Mouse   653 KDMERWARSLNKQKE-NFKNSFQPISALRDDERRESAT---------ADAGYAILEKKGALAERQ 707

  Fly   777 ------GKL-NDYAPNPTVGPMNKLVNAYGGTSDSEEDNAASSQNTQSSAVVSGGGGAEESDYVD 834
                  .|| :|..|:|..|    ||.||.|.|||||:.             ..||...|....|
Mouse   708 HTSMDLPKLASDDRPSPPRG----LVAAYSGESDSEEEQ-------------ERGGPEREEKLTD 755

  Fly   835 FHKLTCLLCKRAFQSLEILQKHLKMSTLHKENL-----AKLNQNTSSSIE----EALAYRDRAKE 890
            :.||.||||:|.|.|.|.|.:|.::|.|||:||     |.|::|...::|    |.:.|||||.|
Mouse   756 WQKLACLLCRRQFPSKEALIRHQQLSGLHKQNLEIHRRAHLSENELEALEKNDMEQMKYRDRAAE 820

  Fly   891 RRLKYGESDPPPPNRSRERFEQEIKTLQSRQKQSTSATPAMPISSSNVGSRLLQKMGWSEGQGLG 955
            ||.|||..:||.|.|   |....|.|.....:|.|..    .:.|.|:|||:||.|||.||.|||
Mouse   821 RREKYGIPEPPEPKR---RKYGGISTASVDFEQPTRD----GLGSDNIGSRMLQAMGWKEGSGLG 878

  Fly   956 RKNQGRTQIIEADGRSNYVGLGNKSGQ--MIPGNDYKSYIKKMMKQRYENA 1004
            ||.||....|||..|....|||.:...  :.....||..:.|.|..|:..|
Mouse   879 RKKQGIVTPIEAQTRVRGSGLGARGSSYGVTSTESYKETLHKTMVTRFNEA 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4887	NP_001259859.1	DUF1777	115..>196	CDD:285811	28/93 (30%)
		RRM_SF	255..335	CDD:302621	25/79 (32%)
		ZnF_RBZ	341..364	CDD:197784	15/22 (68%)
		RanBP2-type Zn finger	342..361	CDD:275375	13/18 (72%)
		RRM1_RRM2_RBM5_like	387..473	CDD:240759	27/85 (32%)
		OCRE_RBM5_like	623..678	CDD:293881	35/54 (65%)
		OCRE repeat 1	628..635	CDD:293881	4/6 (67%)
		OCRE repeat 2	636..643	CDD:293881	6/6 (100%)
		OCRE repeat 3	644..651	CDD:293881	5/6 (83%)
		OCRE repeat 4	652..659	CDD:293881	6/6 (100%)
		OCRE repeat 5	661..668	CDD:293881	4/6 (67%)
		G-patch	935..979	CDD:279867	26/43 (60%)
Rbm10	NP_663602.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..127		40/133 (30%)
		RRM	21..>232	CDD:223796	74/242 (31%)
		RRM1_RBM10	127..211	CDD:241197	28/105 (27%)
		ELAV_HUD_SF	136..381	CDD:273741	73/247 (30%)
		ZnF_RBZ	215..239	CDD:197784	15/23 (65%)
		RanBP2-type Zn finger	217..236	CDD:275375	13/18 (72%)
		RRM2_RBM10	298..384	CDD:241198	27/98 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..487		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..522		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..566		5/28 (18%)
		OCRE_RBM10	564..627	CDD:293886	41/71 (58%)
		OCRE repeat 1	570..577	CDD:293886	4/6 (67%)
		OCRE repeat 2	578..585	CDD:293886	6/6 (100%)
		OCRE repeat 3	586..593	CDD:293886	5/6 (83%)
		OCRE repeat 4	594..601	CDD:293886	6/6 (100%)
		OCRE repeat 5	603..610	CDD:293886	4/6 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..646		11/34 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..753		19/57 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..861		17/49 (35%)
		G-patch	858..902	CDD:279867	26/43 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843021
Domainoid	1	1.000	124	1.000	Domainoid score	I5489
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31330
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2109
Isobase	1	0.950	-	0	Normalized mean entropy	S6718
OMA	1	1.010	-	-		QHG55750
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	1	1.000	-	-		FOG0002462
OrthoInspector	1	1.000	-	-		mtm8864
orthoMCL	1	0.900	-	-		OOG6_102541
Panther	1	1.100	-	-	O	PTHR13948
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.720