DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4887 and rbm-5

DIOPT Version :9

Sequence 1:	NP_001259859.1	Gene:	CG4887 / 33304	FlyBaseID:	FBgn0031318	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_491793.1	Gene:	rbm-5 / 172312	WormBaseID:	WBGene00020346	Length:	925	Species:	Caenorhabditis elegans

Alignment Length:	1049	Identity:	274/1049 - (26%)
Similarity:	408/1049 - (38%)	Gaps:	267/1049 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 GNGDPDLYHSLINDDYRDQDER--------NYNSRSNFENRQFRRHDSFDRRHR----------- 125
            ||.||..:...:.|.|:..:|:        |...|.:....|.|..::....||
Worm    20 GNYDPTDHQRQMEDYYKQYEEQRQVANSFHNTTGRPDLVAMQARLAETEQAIHRLNEEKKQPPPG 84

  Fly   126 ---------------DRDGE--SDRELNDYEYEQRSRDLDSRDRSSTDRDWYHNRSRSREHSRPW 173
                           .|.||  |.|..:.....:|||. .||||..       .|||||..||..
Worm    85 FPIMTTPATQPEISIPRSGENKSSRSPSWAREARRSRS-RSRDRRG-------GRSRSRSPSRRR 141

  Fly   174 NRNNNHDDRSRSNERNTRHRDHRM--YNGGGSNH----NRDRDRDRDREQDRERDRDRDRDRERR 232
            ...:..||||....|:..|...|.  .:..||:|    ||...|.|.|...|||||:..||..|.
Worm   142 TSRDRRDDRSSRRRRDRSHSRSRSPPSSANGSSHWSSSNRHSRRRRSRSYSRERDRNSRRDDRRS 206

  Fly   233 GSSDYDSDEGHMRRNKYRSTTEAL--NIIIIFGLTKEMTRADIMSELIKVNMEPACIRIIRK--Q 293
            ..|:.|         :|......:  |.:.|..:..::....|...|.|....|..:|.:.|  :
Worm   207 NLSNND---------RYSDWNPGVPSNKLAILNMPNDVDNTKITLSLGKCGYLPQDVRTMTKFDK 262

  Fly   294 GTDSSRGIAFVEFNTVEEAKQWMDITQGVLKLNDER-VSMRY--------SHKRIQDWNCNKCGV 349
            .|...|..|||||:..|.|:|||...:|.|.|:|.| :::.|        |..:..||.|..|.:
Worm   263 NTKQIRTFAFVEFSNRETAEQWMTDYEGWLTLDDGRTLAVEYAKGDPAAGSGNKGDDWICAHCSM 327

  Fly   350 CNFKFRFYCFVCKTSREDSETTFSSGSE--GVDEVSTILTKKIMLRNL-DALTNEEAVLTALQLH 411
            .||..|..||.|:.|::.|......|:.  |:....|:|     :|.| |.:.|        .|.
Worm   328 NNFVKRQTCFKCEISKDQSMELEKLGAHMVGMTPCDTLL-----IRGLPDGINN--------SLI 379

  Fly   412 LKDLSKTVSKVLISRDSLTQASRGICYLHFDTLVDSMNVHNALTALDPPLTLDDRVVAITYCID- 475
            ...|...|....||...|:::.| ..||...:..::..:.| || ...|:.:.|:.|.:::|.|
Worm   380 FDSLGALVCLSSISMIKLSESKR-FAYLQMKSADEAKMLLN-LT-YKSPIRIKDKDVQVSWCRDS 441

  Fly   476 ----LEEQQALPKNPKELAVKDSTVNSGNISAVSPSGLGGNYTLADVPRLAEYSASLYASNPAEH 536
                :::|..:           .|...|..|..:.|...||.|.|::
Worm   442 MSKLIQQQMTM-----------LTAGPGKNSVATGSLAQGNMTGAEI------------------ 477

  Fly   537 AYYVQYYTEYYTADINKNNRDSHLTEANSGAAVALS---AIQRKQKKMSSIETTITAAATAAAQA 598
                                          ||.|||   |:::..:::..|.|.:.|.|......
Worm   478 ------------------------------AAAALSKANAVRQASQQVGQIMTGLPAPAANMIPP 512

  Fly   599 AAQVK----ATLAAQVASAPKGNDGKI------------YPTPDVTQYQYDETSGYYYDSTTGLY 647
            ...|.    :......|:.|:..:|.|            |..|:...:.:|...|||.|..|...
Worm   513 NFSVPPPNLSVPPPMQATQPEHQNGVIGMTQTPKGLLPRYLPPNPLTFAHDPNLGYYVDPITKFC 577

  Fly   648 YNAHSQYYYNNETGAYLYWDQRRSTYVLATPASTQAALQEVLADAEQKGEEESKKAKEKEGGNKH 712
            |::.:.||:||.|..:..||....||.   |..|.|.:..  ||     .||.|..|.:||
Worm   578 YDSATGYYFNNATSQWCNWDLTHHTYF---PVETPAVINS--AD-----PEEEKMKKNEEG---- 628

  Fly   713 DKVKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILANEVATTSRGNQGGYADVGFSILEKKERG 777
              .|.|:.:||||.||||:  |:||...|         :::...:..:|......|| .||::|
Worm   629 --PKTAQDLVKDMAKWAKR--QEKDKKKV---------QISIKGKETKGIELKNVFS-NEKQKR- 678

  Fly   778 KLNDYAPNPTVGPMNKLVNAYGGTSDSEED-------NAASSQNTQSS----------AVVSGGG 825
                      :.....|.:     .|.|||       ..:...:|.||          :.:....
Worm   679 ----------IAQTAALFD-----DDEEEDQEEEVRGRRSEEPSTSSSFSSVPLAPRKSTLQDVR 728

  Fly   826 GAEESDYVDFHKLTCLLCKRAFQSLEILQKHLKMSTLHKENL----AKLNQNTSSSIEE------ 880
            .|.|....|..|.||:||||||..:|:|:||::.|.||:.||    |:..:.|::.::|
Worm   729 DAMERALYDETKKTCMLCKRAFSDVEVLRKHVEKSDLHRNNLEAKRAEWGRETAAKLQEEEEDAS 793

  Fly   881 -----ALAYRDRAKERRLKYGESDP--------PPPNRSRERFEQEIKTLQSRQKQSTSATPAMP 932
                 .:.|||||||||.::|....        .||..:..|.|:.|:      |.|..|: ..|
Worm   794 APDLPKIVYRDRAKERRRQFGIDSTGYAFDVMGGPPGPTSVRHEETIR------KVSEEAS-KRP 851

  Fly   933 ISSSNVGSRLLQKMGWSEGQGLGRKNQGRTQIIEADGRSNYVGLGNKSGQMIPGND--YKSYIKK 995
            :..||:|:|||:.|||.||||:|:..||....|||:......|||....:|..|.:  :|...::
Worm   852 LDESNIGNRLLKSMGWKEGQGVGKHAQGIVNPIEAERFVQGAGLGAAGSKMRHGAEASHKEKTRQ 916

  Fly   996 MMKQRYENA 1004
            .:..||.:|
Worm   917 ALYSRYHDA 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4887	NP_001259859.1	DUF1777	115..>196	CDD:285811	28/108 (26%)
		RRM_SF	255..335	CDD:302621	26/92 (28%)
		ZnF_RBZ	341..364	CDD:197784	10/22 (45%)
		RanBP2-type Zn finger	342..361	CDD:275375	8/18 (44%)
		RRM1_RRM2_RBM5_like	387..473	CDD:240759	19/86 (22%)
		OCRE_RBM5_like	623..678	CDD:293881	17/54 (31%)
		OCRE repeat 1	628..635	CDD:293881	1/6 (17%)
		OCRE repeat 2	636..643	CDD:293881	4/6 (67%)
		OCRE repeat 3	644..651	CDD:293881	2/6 (33%)
		OCRE repeat 4	652..659	CDD:293881	3/6 (50%)
		OCRE repeat 5	661..668	CDD:293881	1/6 (17%)
		G-patch	935..979	CDD:279867	22/43 (51%)
rbm-5	NP_491793.1	RRM	<218..>308	CDD:223796	26/89 (29%)
		RRM_SF	222..305	CDD:302621	25/82 (30%)
		ZnF_RBZ	318..340	CDD:197784	9/21 (43%)
		RanBP2-type Zn finger	320..339	CDD:275375	8/18 (44%)
		RRM_SF	361..438	CDD:302621	21/92 (23%)
		OCRE_RBM5_like	554..608	CDD:293881	18/56 (32%)
		OCRE repeat 1	558..565	CDD:293881	1/6 (17%)
		OCRE repeat 2	566..573	CDD:293881	4/6 (67%)
		OCRE repeat 3	574..581	CDD:293881	2/6 (33%)
		OCRE repeat 4	582..589	CDD:293881	3/6 (50%)
		OCRE repeat 5	591..598	CDD:293881	1/6 (17%)
		RED_N	784..>849	CDD:285099	19/71 (27%)
		G_patch	852..898	CDD:197727	22/45 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167829
Domainoid	1	1.000	75	1.000	Domainoid score	I5902
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	222	1.000	Inparanoid score	I2267
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55750
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	1	1.000	-	-		FOG0002462
OrthoInspector	1	1.000	-	-		otm14220
orthoMCL	1	0.900	-	-		OOG6_102541
Panther	1	1.100	-	-	LDO	PTHR13948
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910