DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4887 and rbm10

DIOPT Version :9

Sequence 1:	NP_001259859.1	Gene:	CG4887 / 33304	FlyBaseID:	FBgn0031318	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_009294839.1	Gene:	rbm10 / 101882554	ZFINID:	ZDB-GENE-100922-245	Length:	898	Species:	Danio rerio

Alignment Length:	943	Identity:	273/943 - (28%)
Similarity:	409/943 - (43%)	Gaps:	177/943 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 DQHRGGRGGA----GNGDPDLYHSLINDDYRDQDERNYNSR------SNFENRQFRRHD-SFD-- 121
            |..|.|||..    |....|       .||||.|.|.|...      |:..|.  |:|| |.|
Zfish     2 DYERRGRGDRMGRYGKASDD-------HDYRDMDYRGYGQENGLGLTSSLANT--RQHDGSSDGP 57

  Fly   122 ---------------RRHRDRDGESDRELN----------DYEY----EQRSRDLDS-RDRSSTD 156
                           |:..:|..|..::.|          |||:    |.|.||..| |.|....
Zfish    58 KDFPSGNFSNNRPGFRQKGNRASEVGKDQNIHSRFQHDGKDYEFEAETEARRRDAQSLRSRPKVF 122

  Fly   157 RDWYHNRSRSREHSRPWNRNNNHDDRSRSNERNTRHRDHRMYNGGGSNHNRDRDRDRDREQDRER 221
            .|.........:....|.|.     |.|.|.:...:.:.|......:.:.:.:....|:.|.:.:
Zfish   123 LDQQTPDEEEGDEDNTWGRL-----RGRQNSQGEYNAEWRAEEDKLNRNLKHKQGFPDQVQSQSK 182

  Fly   222 DRDRDRDRERRGSSDYDSDEGHMRRNKYRSTTEAL----NIIIIFGLTKEMTRADIMSELIKVNM 282
            .:|        ||  :|.:|..:....|||..:||    ||:::..|....|..:|.:.|.:..:
Zfish   183 MKD--------GS--FDPEEAEVHDQDYRSDADALQKPSNIVMLRMLPLNATVNEIRARLQEQGI 237

  Fly   283 EPACIRIIRKQGTDSSRGIAFVEFNTVEEAKQWMDITQGVLKLNDERVSMRYSH---KRIQDWNC 344
            :|..:|::|.:.:..|||.||||||.::||.:||:..|.||.:..:||||.||.   :..:||.|
Zfish   238 QPREVRLMRNKSSGQSRGFAFVEFNHLQEASRWMETNQKVLTILGQRVSMHYSDPKPRANEDWLC 302

  Fly   345 NKCGVCNFKFRFYCFVCKTSREDSE------------TTFSSGSEGV------------------ 379
            |||||.|||.|..||.|...:.::|            ......::|:
Zfish   303 NKCGVQNFKRREKCFKCGVPKSEAELKLPLVPKILPLCQLKDSTQGLLPLPAIFQTATSILNLSS 367

  Fly   380 -DEVSTILTKKIMLRNLDALTNEEAVLTALQLHLKDLSKTVSKVLISRDSLTQASRGICYLHFDT 443
             .:.|......::||||...|..||:|:|| .....||.  |.|.:.:|..||.:||..:|...|
Zfish   368 SPQPSEAANDTLILRNLGPHTTLEAILSAL-APFATLSP--SNVRLIKDKQTQLNRGFAFLQLTT 429

  Fly   444 LVDSMNVHNALTALDPPLTLDDRVVAITYCIDLEEQQALPKNPKELAVKDSTVNSGNIS----AV 504
            :|::..:...|.||.|||::|.:::::.:....:....|....:   |..:||.|..|:    ||
Zfish   430 IVEASQLLQILQALQPPLSIDGKLISVEFAKGSKRDVFLTDGSR---VSVATVASTAIAAAQWAV 491

  Fly   505 SPSGLGGNYTLADVPRLAEYSASLYASNPAEHAYYVQYYTEYYTADIN--KNNRDSHLTEANSGA 567
            |.:..|..  ..|:..|.:.:|:           :.|..::..||:..  |....:.||.|:...
Zfish   492 SQTASGAQ--SGDLSVLQQGAAA-----------FSQDGSQSRTAETQAFKGPVTTLLTPADRAV 543

  Fly   568 AVALSAIQRKQKKMSSIETTITAAATAAAQAAAQV--KATLAAQVASAPKGN--DGKIYPTPDVT 628
            |...:|........|.|:...:..:|...|.:.::  |...||.|..|..|.  :.:.||.|||:
Zfish   544 AGETTAASILTHAASQIQLVSSTPSTQDRQTSVEIIGKPQPAACVQPATPGTALECQQYPDPDVS 608

  Fly   629 QYQYDETSGYYYDSTTGLYYNAHSQYYYNNETGAYLYWDQRRSTYVLATPASTQAALQEVLADAE 693
            .|||||:||||||..|||||:.:||||:|..|..|:|||..:.|||   ||.:|:   |..|..|
Zfish   609 TYQYDESSGYYYDPFTGLYYDPNSQYYFNPHTQQYMYWDGEKHTYV---PAPSQS---EDSAGNE 667

  Fly   694 QKGEEESKKAKEKEGGNKHDKVKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILANEVATTSRG 758
            ..|...|.|.|:.:..||.     |::|.||||:|||.||::|:........|.|.....:..|
Zfish   668 LSGAPNSSKDKKDKPKNKS-----AQQIAKDMERWAKSLNRQKENGRSVNTNPRLMTHSRSDDR- 726

  Fly   759 NQGGYADVGFSILEKK----ERGKL---NDYAPNPTVGPMNKLVNAYGGTSDSEEDNAASSQNTQ 816
            .:...||.|:::||.|    ||.::   ....|.....|...|:......:|||::::...:.
Zfish   727 RESASADAGYAVLEMKGALLERPQILMEQIKHPEDRESPPQALLAGCSVETDSEDESSEKQER-- 789

  Fly   817 SSAVVSGGGGAEESDYVDFHKLTCLLCKRAFQSLEILQKHLKMSTLHKENLAKLN-----QNTSS 876
                           ..|:.||.||||:|.|.|.|.|.:|.::|.||::||.:..     .||..
Zfish   790 ---------------LTDWCKLACLLCRRQFPSKEALIRHQQLSELHRQNLEQKRSRTTVSNTQE 839

  Fly   877 SIEEALAYRDRAKERRLKYGESDPPPPNRSRER 909
            ..|..|.|||||.|||.|  ...|..|:..:.|
Zfish   840 GSETELKYRDRAAERREK--GIIPQQPDAKKRR 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4887	NP_001259859.1	DUF1777	115..>196	CDD:285811	25/113 (22%)
		RRM_SF	255..335	CDD:302621	31/83 (37%)
		ZnF_RBZ	341..364	CDD:197784	15/22 (68%)
		RanBP2-type Zn finger	342..361	CDD:275375	13/18 (72%)
		RRM1_RRM2_RBM5_like	387..473	CDD:240759	29/85 (34%)
		OCRE_RBM5_like	623..678	CDD:293881	33/54 (61%)
		OCRE repeat 1	628..635	CDD:293881	4/6 (67%)
		OCRE repeat 2	636..643	CDD:293881	6/6 (100%)
		OCRE repeat 3	644..651	CDD:293881	5/6 (83%)
		OCRE repeat 4	652..659	CDD:293881	5/6 (83%)
		OCRE repeat 5	661..668	CDD:293881	3/6 (50%)
		G-patch	935..979	CDD:279867
rbm10	XP_009294839.1	RRM	<159..>315	CDD:223796	55/165 (33%)
		RRM_SF	210..294	CDD:302621	31/83 (37%)
		ZnF_RBZ	298..322	CDD:197784	15/23 (65%)
		RanBP2-type Zn finger	300..319	CDD:275375	13/18 (72%)
		RRM2_RBM10	375..461	CDD:241198	29/88 (33%)
		OCRE_RBM5_like	603..657	CDD:293881	34/56 (61%)
		OCRE repeat 1	608..615	CDD:293881	4/6 (67%)
		OCRE repeat 2	616..623	CDD:293881	6/6 (100%)
		OCRE repeat 3	624..631	CDD:293881	5/6 (83%)
		OCRE repeat 4	632..639	CDD:293881	5/6 (83%)
		OCRE repeat 5	641..648	CDD:293881	3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587904
Domainoid	1	1.000	116	1.000	Domainoid score	I5905
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31330
Inparanoid	1	1.050	335	1.000	Inparanoid score	I2382
OMA	1	1.010	-	-		QHG55750
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	1	1.000	-	-		FOG0002462
OrthoInspector	1	1.000	-	-		mtm6537
orthoMCL	1	0.900	-	-		OOG6_102541
Panther	1	1.100	-	-	LDO	PTHR13948
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770