DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4887 and LOC100498473

DIOPT Version :9

Sequence 1:	NP_001259859.1	Gene:	CG4887 / 33304	FlyBaseID:	FBgn0031318	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_002935683.3	Gene:	LOC100498473 / 100498473	-ID:	-	Length:	1605	Species:	Xenopus tropicalis

Alignment Length:	1125	Identity:	225/1125 - (20%)
Similarity:	369/1125 - (32%)	Gaps:	424/1125 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GGIRHRNSRSRSRDRDRSPVFR----------NDQHRGGRGG----------AGNGDPDL--YHS 89
            ||....:|..:|.|.|    ||          |::.:.|..|          .|:.|.||  ..:
Frog   733 GGSSQHSSCPQSLDMD----FRDRINTKNMEANNKLKNGMAGPSKAESSSVVLGSSDQDLRKKEN 793

  Fly    90 LINDD--------------YRDQDERNYNSRSNFENRQFRRHDSFDRRHRDRDGESDRELNDYEY 140
            ::.|.              .:|:|.|...|.:..|   ..||.|.              |.|: .
Frog   794 IVQDSKGGISDRVVKTGYVQKDEDLRAGESATPAE---LLRHGSL--------------LFDF-L 840

  Fly   141 EQRSRDLDSRDRSSTDRDWYHNRSRSREHSRPWNRNNNHDDRSR--------------------- 184
            :..:::|  :.:.:||.|...|..|:     .:.::....||..
Frog   841 QLAAQEL--KGKQATDIDAGGNEKRT-----IFTKHTGDPDRKAQVIQGTTSGKPTIVPNSQAAM 898

  Fly   185 ----SNERNTRHRDHR--MYNGGGSNHNRDRDRDRDREQDRERDRDRDRDRERRGSSDYDSDEGH 243
                |.:.:.|:.|::  ...||.|...|..:| ..||..::..:|:|   .||.|    ..||
Frog   899 EFLGSEDTDYRNMDYKDTDLRGGYSLEKRSLER-TFREDLQQGSKDKD---YRRSS----LPEG- 954

  Fly   244 MRRNKYRSTTEALNIIIIFGLTKEMTRADIMSELIKVNMEPACIRIIRKQGTD-------SSRGI 301
                       |..||.:..|....:|.:|::.|..||..|:       .|.:       .|.|.
Frog   955 -----------ATRIIWLENLPMGASREEILNALSTVNKLPS-------HGVNLIGYIPGYSLGS 1001

  Fly   302 AFVEFNTVEEAKQWMDITQGVLKLNDERVSMRY---SHKRIQDWNCNKCGVCNFKFRFYCFVCKT 363
            ..|||:.||||...|:..:|.|....::||::|   |.|    |:|.:|.|.|...:..|:.|..
Frog  1002 VCVEFSLVEEAVGCMEACKGFLLFRGKKVSLKYIPNSEK----WSCQQCKVVNVLSKERCWQCSA 1062

  Fly   364 SR------------EDSETTFSS--------------GSEGVD---------------------- 380
            .|            :||:...||              .|...|
Frog  1063 LRSGSDHLPDRDLTKDSKNASSSKLQRGRKRKSKQRATSSSPDKWKEKTPPSERSPMAIRRQTKE 1127

  Fly   381 -------EVSTILTKKIMLRNLDALTNEEAVLTALQLHLKDLSKTVSKVLISRDSLTQASRGICY 438
                   |.:||:.|.|.|.     :..::|:.||:.:|: ||.:..:::.:|.. ........:
Frog  1128 GKLKAEAESTTIIMKGISLS-----SRPDSVVKALKPYLQ-LSPSNVRIIKNRKH-DHGGGTFGF 1185

  Fly   439 LHFDTLVDSMNVHNALTALDPPLTLDDRVVAITYCIDLEEQQALPKNPKELAVKDSTVNSGNISA 503
            :...:..:::.:...:..|.||||:|.:.|.::..:.......| ||.:
Frog  1186 IDLKSHKEAVRLIVLIRELKPPLTVDGKPVTVSLAVGQRRTDPL-KNEQ---------------- 1233

  Fly   504 VSPSGLGGNYTLADVPRLAEYSASLYASNPAEHAYYVQYYTEYYTADINKNNRDSHLTEANSGAA 568
                   |.:..|                                   ||.|.        ||.|
Frog  1234 -------GKFNKA-----------------------------------NKKNL--------SGQA 1248

  Fly   569 VALSAIQRKQKKMSSIETTITAAATAAAQAAAQVKATLAAQVASAPKGNDGKIYPTPDVTQYQYD 633
                  :|:|::                        .::..||.:...:||        ..|.||
Frog  1249 ------KRRQRR------------------------AMSHTVADSRADSDG--------PSYIYD 1275

  Fly   634 ETSGYYYDSTTGLYYNAHSQYYYNNETGAYLYWDQRRSTYVLATPASTQAALQEVLADAEQKGEE 698
            ..||.|.|..|..||:..|........|              .||             ..::|:.
Frog  1276 AESGLYIDPLTNTYYDPTSPRVNPKAEG--------------ETP-------------RREEGQR 1313

  Fly   699 ESKKAKEKEGGNKHDKVKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILANEVATTSRGNQGGY 763
            |:.:.:|:...:...:....::..:|...|.....:|:              .|..|.|
Frog  1314 ETSETREQRRAHGRYRSPSPQRRKRDEYSWRSGSEEKE--------------SVPRTRR------ 1358

  Fly   764 ADVGFSILEKKER-------------GKLNDYAPNPTVGPMNKLVNAYGGTSDSEEDN------- 808
               ||...|.|.|             .|....|..|.|.|:..|:..|||.|:.|:|.
Frog  1359 ---GFREEEDKPRVDEPFKKPLPPSIAKKEPPASEPKVNPLIGLIGEYGGDSEEEDDEQLPLLRK 1420

  Fly   809 -------------AASSQNTQSSAVVSGGGGAEESDYVDFHKLTCLLCKRAFQSLEILQKHLKMS 860
                         |..||:..|||..|....:.:....|:.|:.||||:|.|.:.|.|.||.::|
Frog  1421 KTPPQPPTQPPPPAPVSQSKPSSAPPSTSINSVQEKLTDWTKIACLLCRRQFPNKEALIKHQQLS 1485

  Fly   861 TLHKENLAKLNQNTSSSIEEALAY---RDRAK----ERRLKYGESDPPPPNRSRERFEQEIKTLQ 918
            .|||:||| ::|....| |:.|||   ::|.:    :|||:..:.:.....|..|...|: |:..
Frog  1486 DLHKQNLA-IHQKIRQS-EKELAYLQQKEREENHSIQRRLQQAKKELEELEREEEGSRQD-KSGH 1547

  Fly   919 SRQKQSTSATPAMPISSSNVGSRLLQKMGWSEGQGLGRKNQGRTQIIEADGRSNYVGLGNKSGQM 983
            .:..:|.........|||.|.:.|..|...|                              |.::
Frog  1548 HKLNESPPEKKRQKYSSSEVSADLHHKSDKS------------------------------SAKV 1582

  Fly   984 IP-GNDYKSYIKKMMKQRYE 1002
            :| |..|:..::|::..||:
Frog  1583 VPTGESYRENMRKLILARYK 1602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4887	NP_001259859.1	DUF1777	115..>196	CDD:285811	16/105 (15%)
		RRM_SF	255..335	CDD:302621	26/89 (29%)
		ZnF_RBZ	341..364	CDD:197784	7/22 (32%)
		RanBP2-type Zn finger	342..361	CDD:275375	6/18 (33%)
		RRM1_RRM2_RBM5_like	387..473	CDD:240759	17/85 (20%)
		OCRE_RBM5_like	623..678	CDD:293881	12/54 (22%)
		OCRE repeat 1	628..635	CDD:293881	3/6 (50%)
		OCRE repeat 2	636..643	CDD:293881	4/6 (67%)
		OCRE repeat 3	644..651	CDD:293881	3/6 (50%)
		OCRE repeat 4	652..659	CDD:293881	1/6 (17%)
		OCRE repeat 5	661..668	CDD:293881	1/6 (17%)
		G-patch	935..979	CDD:279867	6/43 (14%)
LOC100498473	XP_002935683.3	MSCRAMM_ClfB	<446..676	CDD:411414
		RRM_SF	957..1034	CDD:418427	24/83 (29%)
		RRM_SF	1135..1222	CDD:418427	20/93 (22%)
		OCRE_RBM6	1255..1312	CDD:293882	18/91 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110