Protein Alignment IntS14 and Ints14

DIOPT Version :10

• Sequence 1: NP_608579.1
• Gene: IntS14 / 33300
• FlyBaseID: FBgn0031314
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_780362.2
• Gene: Ints14 / 69882
• MGIID: 1917132
• Length: 515
• Species: Mus musculus
• Alignment Length: 570
• Identity: 192/570 - (33%)
• Similarity: 290/570 - (50%)
• Gaps: 96/570 - (16%)

  Fly     1 MPTLIALDASLSMLRP--VPGRNEHTYQSLATKGIQHLLDNLTAAGKLEHVALLSYSTTAELKVD 63
            |||::.:|.||||.||  |.|..|:..:.||..|:..|.:::....|||..||:.:|:..||.|.
Mouse     1 MPTVVVMDVSLSMTRPVSVEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVP 65

  Fly    64 FTRDYDQVRQAVKKVEPVDKACLMSMLKAVVSIM-SPWGNQNILQVVVFTDCGLGFGNTSITGFL 127
            |||||:.:::|:..::..||.||.|.|..|.:|: ..||.....|||:.||..||.|..|:...|
Mouse    66 FTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSL 130

  Fly   128 EAYAEKESEPEFGFLKTLANYNLNFICLGLHGDYYFTRGLAVYQQLLDKVSLKGQLFMTKPAKSS 192
            ....::.....|.......: .|..:|:....:...|..|...::|:|..:.:||:|
Mouse   131 ATQNQRSESNRFPLPFPFPS-KLYVMCMANLEELQSTDSLECLERLIDLNNGEGQIF-------- 186

  Fly   193 DAVEGNPNPNPNPSHKSELGRTTVFELIERLCEASYKSSEVTLKCGSYFRMEASVLLWPPTAPY- 256
             .::|            .|....|..:..:|.:.:|......||||   .:.|.|.::|...|:
Mouse   187 -TIDG------------PLCLKNVQSMFGKLIDLAYTPFHAVLKCG---HLTADVQVFPRPEPFV 235

  Fly   257 --EQKSHIFGREPTIRHTDQKIEVCGFLSLSDIGSPATLSRHWVLPKVEREKSGSSRRSGNLSAA 319
              |:...|    |.:.:||  :|:.||:.::||.||..||||.||| :...|.|....:|
Mouse   236 IDEEIDPI----PKVINTD--LEIVGFIDIADISSPPVLSRHLVLP-IALNKEGDEVGAG----- 288

  Fly   320 AKPPKLNLDTSNPNYELEKLEADIKEFYAKDSKDTEESGDDDVTIVLKPGPQTEQQKENLCVLLH 384
                                        ..|..:.|.|.:           |...:..|.|||||
Mouse   289 ----------------------------ITDDNEDENSAN-----------QIAGKIPNFCVLLH 314

  Fly   385 GALKMENMAALVRVGDKWYGFIYAFTDSKKKSNLMLNILPPGTNVIPWLGDLESLG--------- 440
            |:||:|.|.|||::|.:|:|.:|:..|||||||||:::..||...:||||.:..||
Mouse   315 GSLKVEGMVALVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENP 379

  Fly   441 FPEDLAPGETASFPVR-ADRRSYSQSSVVWIRQASLQSDVQKVLRHAKKMPDKTQHFYKELNRIR 504
            :.||   ...:.||:: .::|||:|:..|||:.:.||:||||:||:|:|:|:|||.|||||||:|
Mouse   380 YGED---DNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLR 441

  Fly   505 RAALALGFVELLEALAMLLEKECAHLSLNGASNDCTLQLQHAATELRKTS 554
            :||||.||::||:.:|.:||:||..|. :.|..|...||.|||.:|:..|
Mouse   442 KAALAFGFLDLLKGVADMLERECTLLP-DTAHPDAAFQLTHAAQQLKLAS 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS14	NP_608579.1	ChlD	<4..173	CDD:440853	54/171 (32%)
		IntS14_b-barrel	228..426	CDD:466081	62/200 (31%)
		IntS14_C	468..566	CDD:466653	48/87 (55%)
Ints14	NP_780362.2	VWA_2	3..114	CDD:463909	43/110 (39%)
		IntS14_b-barrel	209..356	CDD:466081	62/200 (31%)
		IntS14_C	405..509	CDD:466653	48/87 (55%)