Protein Alignment APLP1 and Appl

DIOPT Version :10

• Sequence 1: NP_001019978.1
• Gene: APLP1 / 333
• HGNCID: 597
• Length: 651
• Species: Homo sapiens
• Sequence 2: NP_001245448.1
• Gene: Appl / 31002
• FlyBaseID: FBgn0000108
• Length: 890
• Species: Drosophila melanogaster
• Alignment Length: 891
• Identity: 203/891 - (22%)
• Similarity: 318/891 - (35%)
• Gaps: 283/891 - (31%)

Human    29 LLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC--GRLTLHRDL-RTGRWEPDPQRSR---RCLRD 87
            ||||:...:.::......||......|:|.||  |::...:.| ..|||..|..:..   .||||
  Fly     9 LLLRSLWVVLAIGTAQVQAASPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLRD 73

Human    88 PQRVLEYCRQMYPELQIARVEQATQAIPMERWC--GGSRSGSCAHPHHQVVPFRCLPGEFVSEAL 150
            ...:|:||::.||...|..:.:::....:..||  |...:..|...|..:.||||| |.|.|:||
  Fly    74 KMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-GPFQSDAL 137

Human   151 LVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPP--- 212
            ||||||.|.|.....:|....|.:|....||..:|:.:....||||||...|.|||:||||.
  Fly   138 LVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFK 202

Human   213 -----------PGTP-------------------------------------------------- 216
                       |..|
  Fly   203 TDEIHVKKTDLPVMPAAQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDDEEDDMVA 267

Human   217 DPSGTAVGDPST------------------RSWPPGSRVE----GAEDEEE-EESFPQ------- 251
            |.:.||.|.|:|                  .|...|...|    |:|.|.| |.|:.|
  Fly   268 DEAATAGGSPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQSGGAKVV 332

Human   252 ------------PVDDYFVEPPQAEEEEETVPPPSSHTLAVV-----------GKVTPTPRPTDG 293
                        ||.....:.|...|...:.|..|:...|.|           |....|.:||.
  Fly   333 SLKSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPSTAQPTS- 396

Human   294 VDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKAD-------RQALN 351
             |.||.......||:.:..::..|||....::..||::|:..:.:.:::..||       :|.:.
  Fly   397 -DPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFKQRMT 460

Human   352 EHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRY 416
            ..||:.:|.|||:.:.|:.:|...|..||:|.||.::|.|:..:..||...||.|..|...|::.
  Fly   461 ARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNAHHVEKCLQKL 525

Human   417 LRAEQKEQRHTLRHYQHVA-AVDP---EKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQEL 477
            |||..|::.|.|.||:|:. :..|   |.|...|.:....|..|:..||||:.:|.:.|    ||
  Fly   526 LRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQSMTMLKRYP----EL 586

Human   478 RPQIQELLHSEHL---GPSELEAPAPGGSSEDKGGLQPP-------------------------- 513
            ..:|.:|::...|   ...::...:.|.|.|.:.|:...
  Fly   587 SAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRVEIERKVAEKERLRLAEKQRKEQR 651

Human   514 -----------------------DSKDADTPMTLPKGSTEQDAASPEKEKMNP------------ 543
                                   .|:.|:......:.||:..|...::||..|
  Fly   652 AAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPTQSSTQSQAQQQQQEKSLPGKELGPDAALVT 716

Human   544 -----------------LEQYERKVNASVPRGFP-FHSSEIQR--DELAPA-------------- 574
                             .|..|..|:..|....| .....:||  :::|.|
  Fly   717 AANPNLETTKSEKDLSDTEYGEATVSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFM 781

Human   575 ---------GTGVSRE------------------AVSGLLIMGAGGGSLIVLSMLLLRRKKPYGA 612
                     ...:.||                  :.:|:.:|.|     :.:.:.:.:.:.....
  Fly   782 THDLGHRESSFSLRREFAQHAHAAKEGRNVYFTLSFAGIALMAA-----VFVGVAVAKWRTSRSP 841

Human   613 ISHGVVEVDPM----------LTLEEQQLRELQRHGYENPTYRFLE 648
            .:.|.:|||.:          :..||:.:..:|.:|||||||::.|
  Fly   842 HAQGFIEVDQVGCQNVTTHHPIVREEKIVPNMQINGYENPTYKYFE 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APLP1	NP_001019978.1	A4_EXTRA	46..211	CDD:128326	63/172 (37%)
		GFLD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217	50..146		31/103 (30%)
		CuBD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217	154..212		24/57 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	214..287		26/175 (15%)
		APP_E2	285..467	CDD:463752	59/192 (31%)
		O-glycosylated at three sites	285..305		6/19 (32%)
		Heparin-binding. /evidence=ECO:0000250	310..342		6/31 (19%)
		Heparin-binding. /evidence=ECO:0000250	410..441		11/34 (32%)
		Collagen-binding. /evidence=ECO:0000250	442..459		4/16 (25%)
		JMTM_APLP1	565..649	CDD:411991	24/137 (18%)
		Basolateral sorting signal. /evidence=ECO:0000250	605..616		0/10 (0%)
		Interaction with DAB1. /evidence=ECO:0000250	633..650		9/16 (56%)
		Interaction with DAB2. /evidence=ECO:0000250	637..651		8/12 (67%)
		Clathrin-binding. /evidence=ECO:0000255	641..644		2/2 (100%)
		NPXY motif, contains endocytosis signal	641..644		2/2 (100%)
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	63/172 (37%)
		APP_E2	388..580	CDD:463752	59/193 (31%)
		DDRGK	632..>682	CDD:370664	2/49 (4%)
		APP_amyloid	834..887	CDD:463129	14/52 (27%)