DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APLP1 and Aplp1

DIOPT Version :9

Sequence 1:	NP_001019978.1	Gene:	APLP1 / 333	HGNCID:	597	Length:	651	Species:	Homo sapiens
Sequence 2:	NP_031493.2	Gene:	Aplp1 / 11803	MGIID:	88046	Length:	654	Species:	Mus musculus

Alignment Length:	655	Identity:	581/655 - (88%)
Similarity:	608/655 - (92%)	Gaps:	5/655 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTL 65
            |||.||||||..||...|||||||||.|||||||.|:|:||.|||.|||||||||||||||||||
Mouse     1 MGPTSPAARGQGRRWRPPPLPLLLPLSLLLLRAQLAVGNLAVGSPSAAEAPGSAQVAGLCGRLTL 65

Human    66 HRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAH 130
            ||||||||||||||||||||.||||||||||||||||.|||||||.|||||||||||:|||.|||
Mouse    66 HRDLRTGRWEPDPQRSRRCLLDPQRVLEYCRQMYPELHIARVEQAAQAIPMERWCGGTRSGRCAH 130

Human   131 PHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLL 195
            |||:||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 PHHEVVPFHCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLL 195

Human   196 PCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEP 260
            ||||||||||||||||||.||:|||.|.|||||||||.|.|.||.|||||.||||||||||||||
Mouse   196 PCGSDRFRGVEYVCCPPPATPNPSGMAAGDPSTRSWPLGGRAEGGEDEEEVESFPQPVDDYFVEP 260

Human   261 PQA----EEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERR 321
            |||    |||||..|||||||..:|.:||||||||||||:||||||||.||||||||||||||||
Mouse   261 PQAEEEEEEEEERAPPPSSHTPVMVSRVTPTPRPTDGVDVYFGMPGEIGEHEGFLRAKMDLEERR 325

Human   322 MRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALIND 386
            |||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 MRQINEVMREWAMADSQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALIND 390

Human   387 QRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHT 451
            ||||||||||||||.|||||||||:||||||||||||||||||||||||||||||||||||||.|
Mouse   391 QRRAALEGFLAALQGDPPQAERVLMALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVQT 455

Human   452 HLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSK 516
            ||||||||:|||||||||||||||||||||||||.:||||||||:|..||.||||||.||||:||
Mouse   456 HLQVIEERMNQSLGLLDQNPHLAQELRPQIQELLLAEHLGPSELDASVPGSSSEDKGSLQPPESK 520

Human   517 DADTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSRE 581
            | |.|:|||||||:|:::|..:||:.||||||:|||||.|||||||||:||||||||:|||||||
Mouse   521 D-DPPVTLPKGSTDQESSSSGREKLTPLEQYEQKVNASAPRGFPFHSSDIQRDELAPSGTGVSRE 584

Human   582 AVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRF 646
            |:|||||||||||||||||:||||:|||||.||||||||||||||||||||||||||||||||||
Mouse   585 ALSGLLIMGAGGGSLIVLSLLLLRKKKPYGTISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRF 649

Human   647 LEERP 651
            |||||
Mouse   650 LEERP 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APLP1	NP_001019978.1	A4_EXTRA	46..211	CDD:128326	156/164 (95%)
		GFLD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	50..146		88/95 (93%)
		APP_N	55..154	CDD:280358	91/98 (93%)
		CuBD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	154..212		57/57 (100%)
		APP_Cu_bd	156..211	CDD:289676	54/54 (100%)
		Copper-binding. /evidence=ECO:0000250	158..178		19/19 (100%)
		Zinc-binding	204..211		6/6 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..287		56/76 (74%)
		APP_E2	285..467	CDD:289677	174/181 (96%)
		O-glycosylated at three sites	285..305		18/19 (95%)
		Heparin-binding. /evidence=ECO:0000250	310..342		30/31 (97%)
		Heparin-binding. /evidence=ECO:0000250	410..441		29/30 (97%)
		Collagen-binding. /evidence=ECO:0000250	442..459		15/16 (94%)
		APP_amyloid	597..648	CDD:287486	47/50 (94%)
		Basolateral sorting signal. /evidence=ECO:0000250	605..616		8/10 (80%)
		Interaction with DAB1. /evidence=ECO:0000250	633..650		16/16 (100%)
		Interaction with DAB2. /evidence=ECO:0000250	637..651		13/13 (100%)
		Clathrin-binding. /evidence=ECO:0000255	641..644		2/2 (100%)
		NPXY motif, contains endocytosis signal	641..644		2/2 (100%)
Aplp1	NP_031493.2	A4_EXTRA	46..211	CDD:128326	156/164 (95%)
		GFLD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	50..146		88/95 (93%)
		APP_N	55..154	CDD:280358	91/98 (93%)
		CuBD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	154..212		57/57 (100%)
		APP_Cu_bd	156..211	CDD:289676	54/54 (100%)
		Copper-binding	158..178		19/19 (100%)
		Zinc-binding. /evidence=ECO:0000250	204..211		6/6 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..297		62/82 (76%)
		APP_E2	289..471	CDD:289677	174/181 (96%)
		Heparin-binding. /evidence=ECO:0000250	314..346		30/31 (97%)
		Heparin-binding. /evidence=ECO:0000250	414..445		29/30 (97%)
		Collagen-binding. /evidence=ECO:0000250	446..463		15/16 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..580		61/83 (73%)
		Basolateral sorting signal. /evidence=ECO:0000250	608..619		8/10 (80%)
		APP_amyloid	<612..651	CDD:287486	37/38 (97%)
		Interaction with DAB1	636..652		15/15 (100%)
		Interaction with DAB2. /evidence=ECO:0000269\|PubMed:11247302	640..654		13/13 (100%)
		NPXY motif, contains endocytosis signal	644..647		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83965133
Domainoid	1	1.000	351	1.000	Domainoid score	I13392
eggNOG	1	0.900	-	-		E1_KOG4295
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68447
Inparanoid	1	1.050	1182	1.000	Inparanoid score	I4502
Isobase	1	0.950	-	0	Normalized mean entropy	S7440
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50020
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001588
OrthoInspector	1	1.000	-	-		oto111988
orthoMCL	1	0.900	-	-		OOG6_119308
Panther	1	1.100	-	-	LDO	PTHR23103
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2378
SonicParanoid	1	1.000	-	-		X996
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.240