Protein Alignment Tango14 and NUS1

DIOPT Version :10

• Sequence 1: NP_608577.2
• Gene: Tango14 / 33298
• FlyBaseID: FBgn0031312
• Length: 278
• Species: Drosophila melanogaster
• Sequence 2: NP_612468.1
• Gene: NUS1 / 116150
• HGNCID: 21042
• Length: 293
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 86/321 - (26%)
• Similarity: 129/321 - (40%)
• Gaps: 88/321 - (27%)

  Fly    16 LVGGYELMWRL--------RERLNALAVR--SYD-LWR--SKAAREA------------------ 49
            :.|.|||:||:        |...:.|.||  ::: :||  .:||..|
Human     1 MTGLYELVWRVLHALLCLHRTLTSWLRVRFGTWNWIWRRCCRAASAAVLAPLGFTLRKPPAVGRN 65

  Fly    50 -----------------HERRVLADCRSQLTKTPQHLVLVISPVDAGVDAVLLSRIFDFALDVGI 97
                             |..|..||.|| |.|.|.|:.|||:.|:.......::.:..:.:.|||
Human    66 RRHHRHPRGGSCLAAAHHRMRWRADGRS-LEKLPVHMGLVITEVEQEPSFSDIASLVVWCMAVGI 129

  Fly    98 KHVSLYD-----RRTKGRGYVDMADLCRSTNADTG-SCLKWPPVASPSKLENQPKNGQKTNGYVN 156
            .::|:||     :|...|   .|.::.:......| .|.|:    ||....:..|:.|..|.:
Human   130 SYISVYDHQGIFKRNNSR---LMDEILKQQQELLGLDCSKY----SPEFANSNDKDDQVLNCH-- 185

  Fly   157 GSHSPQLQLHQISASDGHALIA----DVCRELYEDSKTELVQSLLKQKREALTEQISDMLSKRLG 217
                  |.:..:|..||.|.|.    |.|:             |:.||::..|:...|.|:..|.
Human   186 ------LAVKVLSPEDGKADIVRAAQDFCQ-------------LVAQKQKRPTDLDVDTLASLLS 231

  Fly   218 FE-APEPELGIVFARQTCTYGLLPWHARFTEFHTHPSGRHFDVETFASILCKYSRCEQRWG 277
            .. .|:|:|.:.|.....|.|.||||.|.||..:.||..:...|.|.|.|.:|:.||||.|
Human   232 SNGCPDPDLVLKFGPVDSTLGFLPWHIRLTEIVSLPSHLNISYEDFFSALRQYAACEQRLG 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tango14	NP_608577.2	None
NUS1	NP_612468.1	UppS	<196..293	CDD:439791	37/110 (34%)
		RXG motif, crucial for prenyltransferase activity. /evidence=ECO:0000269|PubMed:32817466, ECO:0000305|PubMed:28842490	290..292		1/1 (100%)