DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS3 and MFS15

DIOPT Version :9

Sequence 1:	NP_608572.1	Gene:	MFS3 / 33292	FlyBaseID:	FBgn0031307	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_611375.2	Gene:	MFS15 / 37168	FlyBaseID:	FBgn0034392	Length:	497	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	167/513 - (32%)
Similarity:	267/513 - (52%)	Gaps:	71/513 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RYVLALLGSIGMAIVYGLKVNLSVAMVAMVNHTAIKAHGDGGGHGGHGSVILSNASQVSLVEECN 83
            |::..:|...|:|:.|.|:||||||:|||.:.                     |||        |
  Fly    27 RHLQCILVFFGLAVAYSLRVNLSVAIVAMTDR---------------------NAS--------N 62

  Fly    84 PPGGASNVTAKVEDGP-FDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVV 147
            |            |.| |||:|..:..|||.:||||:|:|||..:::..:.||:::.:.|.|...
  Fly    63 P------------DFPEFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSC 115

  Fly   148 CTLLTPVFTELHYGG---LILMRVLEGVGGGASFPAMHVMIASWAPPTERMVMSTIIYVGTSAGT 209
            ..|||| |..:: ||   ::::|.::|:..|..||:.|..::.|||..||..:....|.|:..||
  Fly   116 LALLTP-FCAVN-GGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGT 178

  Fly   210 ALSILLAG-VCSAQWGWESVFYVMGALSCIWMLLWVILVQDNPNKQRFISLEERQMITSS----- 268
            .:.:.::| :.|:..||.|.||:.|.:..:|..:|:.|....|.:...|:..||:.|.||
  Fly   179 VVMLSVSGYIASSSLGWPSTFYIPGCVGIVWSFVWLYLCSSTPAQHPTITPNERRFIESSGQARR 243

  Fly   269 ---LGTEQKTEHHPAVPWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAA 330
               .|.|:  :..|..||.::||||||..:::||..:|:|::..|.|||.:||.||..::.:|..
  Fly   244 PSDAGREE--QPRPPTPWWRIFTSVPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGP 306

  Fly   331 LSALPYFPMIIFSICLGKLLDSLQAKGK-ITTTVARKTATSICTLIPGVCLLVLCYI--GCRHYE 392
            |||||||.||:.:.....|.|:|:.:|. |....:||...::...:|.:.|:.|.||  |..:..
  Fly   307 LSALPYFAMILLTCVFIWLSDTLKQRGTVIPLGFSRKFFNTLGMWLPMLALIGLGYITEGEANVR 371

  Fly   393 -AVSVMSVGIVAMGSMFSGFLSNHIDIAPNFAGTLVALTNTAATLPGIVVPLFVGFVTKGNQNIG 456
             |:.:::..:....:.:.||..||||::||:||||:.:||.||....|:.||.||.:.....|..
  Fly   372 LAIGLLTAAVATNSATYLGFHVNHIDLSPNYAGTLMGITNCAANFMSILAPLIVGLIVWDETNPA 436

  Fly   457 AWRIIFGVTIVLFALEFLVFVFLGSGSEQPWNKAGTPKDP---------EAKDEKTPL 505
            .|||:|..|..::.:..|:|:..|....||||...|.:.|         |..:::.||
  Fly   437 QWRIVFFFTAFVYFIGNLLFMLFGRTRVQPWNSRPTTRTPSPGGGGERDEGTEDRGPL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS3	NP_608572.1	2A0114euk	19..489	CDD:129972	161/486 (33%)
MFS3	NP_608572.1	MFS	100..479	CDD:119392	135/394 (34%)
MFS15	NP_611375.2	2A0114euk	18..469	CDD:129972	161/486 (33%)
MFS15	NP_611375.2	MFS	31..459	CDD:119392	156/472 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46132at33392
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
	9	8.970