DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS3 and VGlut

DIOPT Version :9

Sequence 1:	NP_608572.1	Gene:	MFS3 / 33292	FlyBaseID:	FBgn0031307	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	134/498 - (26%)
Similarity:	229/498 - (45%)	Gaps:	72/498 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VPARYVLALLGSIGMAIVYGLKVNLSVAMVAMVNHTAIKAHGDGGGHGGHGSVILSNASQVSLVE 80
            :||||.:|.:..:|..|.:|::.|:|.|.:                .|.|...:..|
  Fly    92 MPARYTIATMACVGFMIAFGMRCNMSAAKL----------------KGEHNGTVFMN-------- 132

  Fly    81 ECNPPGGASNVTAKVEDGPFDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAIN 145
                                 |:..::..:.|.:||||||:|||...:|..|.|..:...|:..:
  Fly   133 ---------------------WTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSS 176

  Fly   146 VVCTLLTPVFTELHYGGLIL-MRVLEGVGGGASFPAMHVMIASWAPPTERMVMSTIIYVGTSAGT 209
            ....|..|....|.:|.::: :|||:|:..|.::||.|.:...||||.||..::|:.:.|:.||.
  Fly   177 ATLHLFVPFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGV 241

  Fly   210 ALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVQDNPNKQRFISLEERQMITSSLGTEQK 274
            .:.:.|:|:.:...|:::.||..|....||.:.|:.|..:||.|...||:.|.:.|..|||...
  Fly   242 VVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGESA- 305

  Fly   275 TEHHPAV------PWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSA 333
               ||.:      ||.::..|:|.:||::|:.|.::.:|:.::....::|....|.|.....:.:
  Fly   306 ---HPTMPSLKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGS 367

  Fly   334 LPYFPMIIFSICLGKLLDSLQAKGKITTTVARKTATSICTLIPGVCLLVLCYIGCRHYE----AV 394
            ||:..|.......|.|.|.|:..|.::||..||...  |   .|..:..|.::...|..    |:
  Fly   368 LPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFN--C---GGFGMEGLFFLFVAHSSTATGAM 427

  Fly   395 SVMSVGIVAMGSMFSGFLSNHIDIAPNFAGTLVALTNTAATLPGIVVPLFVGFVTKGNQNIGAWR 459
            ..::.|:...|...||:..||:||||.:|..|:.|:|...||.||:||..:..:.:.|.. |.|.
  Fly   428 FALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPT-GCWT 491

  Fly   460 IIFGVTIVLFALEFLVFVFLGSGSEQPWNKAGTPKDPEAKDEK 502
            .:|.:...:..:....:....||..|||      .:|.|:::|
  Fly   492 TVFTLAACVHLVGCTFYGIFASGELQPW------AEPPAEEQK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS3	NP_608572.1	2A0114euk	19..489	CDD:129972	129/480 (27%)
MFS3	NP_608572.1	MFS	100..479	CDD:119392	112/389 (29%)
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	122/468 (26%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	115/427 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.070