DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS3 and Slc17a5

DIOPT Version :9

Sequence 1:	NP_608572.1	Gene:	MFS3 / 33292	FlyBaseID:	FBgn0031307	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_766361.1	Gene:	Slc17a5 / 235504	MGIID:	1924105	Length:	495	Species:	Mus musculus

Alignment Length:	470	Identity:	165/470 - (35%)
Similarity:	249/470 - (52%)	Gaps:	22/470 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ARYVLALLGSIGMAIVYGLKVNLSVAMVAMVNHTAIKAHGDGGGHGGHGSVILSNASQVSLVEEC 82
            |||.||:|...|..::|.|:||||||:|.||:               ..:.:..|.:.....|..
Mouse    38 ARYNLAILAFCGFFVLYALRVNLSVALVDMVD---------------SNTTLTDNRTSKECAEHS 87

  Fly    83 NPPGGASNVTAKVEDGPFDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVV 147
            .|.....|.|.|    .:.|....||.:|..:|:||:|:|||..::|.....|.::...:....|
Mouse    88 APIKVHHNHTGK----KYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSV 148

  Fly   148 CTLLTPVFTELHYGGLILMRVLEGVGGGASFPAMHVMIASWAPPTERMVMSTIIYVGTSAGTALS 212
            .||.||:..:|....|:::|.|||:|.|.:|||||.|.:|||||.||..:.||.|.|...||.:|
Mouse   149 FTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVIS 213

  Fly   213 ILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVQDNPNKQRFISLEERQMITSSLGTEQKTEH 277
            :.|:|:......|..|||:.|.:..:|.:||:.:|.|.|...:.||..|::.|.|||..:..::
Mouse   214 LPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTISHYEKEYIVSSLKNQLSSQ- 277

  Fly   278 HPAVPWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPMIIF 342
             ..||||.:..|:|.|||::||...|:.:|..|..:|.|||::|:|||..|..|||||||...:.
Mouse   278 -KVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLC 341

  Fly   343 SICLGKLLDSLQAKGKITTTVARKTATSICTLIPGVCLLVLCYIGCRHYEAVSVMSVGIVAMGSM 407
            .|..|:..|.|:.|...:|...|:..:.:..:.|.|.|:...:|||.:..||:.:::.....|..
Mouse   342 MILCGQAADYLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFA 406

  Fly   408 FSGFLSNHIDIAPNFAGTLVALTNTAATLPGIVVPLFVGFVTKGNQNIGAWRIIFGVTIVLFALE 472
            .|||..||:||||::||.|:.:|||.||:||:..|:....:|..| .|..|:.:|.:...:....
Mouse   407 SSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTPDN-TIREWQTVFCIAAAINVFG 470

  Fly   473 FLVFVFLGSGSEQPW 487
            .:.|.....|..|.|
Mouse   471 AIFFTLFAKGEVQSW 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS3	NP_608572.1	2A0114euk	19..489	CDD:129972	164/469 (35%)
MFS3	NP_608572.1	MFS	100..479	CDD:119392	138/378 (37%)
Slc17a5	NP_766361.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Dileucine internalization motif. /evidence=ECO:0000250	22..23
		2A0114euk	30..491	CDD:129972	165/470 (35%)
		MFS	99..478	CDD:119392	139/385 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3068
OMA	1	1.010	-	-		QHG53923
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.870