DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS3 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_608572.1	Gene:	MFS3 / 33292	FlyBaseID:	FBgn0031307	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_892004.1	Gene:	Slc17a8 / 216227	MGIID:	3039629	Length:	601	Species:	Mus musculus

Alignment Length:	500	Identity:	154/500 - (30%)
Similarity:	250/500 - (50%)	Gaps:	68/500 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VPARYVLALLGSIGMAIVYGLKVNLSVAMVAMVNHTAIKAHGDGGGHGGHGSVILSNASQVSLVE 80
            :|.||::|::..:|..|.:|::.||.||:|.|||::.:...|
Mouse    85 IPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDG----------------------- 126

  Fly    81 ECNPPGGASNVTAKVEDGPFDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAIN 145
                       ..:::...|:|.....|.:...:||||:|:|||...::..|:|..|  |..||.
Mouse   127 -----------KPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAASRV--FGAAIF 178

  Fly   146 VVCTL--LTPVFTELHYGGLILMRVLEGVGGGASFPAMHVMIASWAPPTERMVMSTIIYVGTSAG 208
            :..||  ..|....:|||.::.:|:|:|:..|.::||.|.|.:.||||.||..::|..:.|:.||
Mouse   179 LTSTLNMFIPSAARVHYGCVMGVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAG 243

  Fly   209 TALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVQDNPNKQRFISLEERQMITSSLG--- 270
            ..:::.||||.....||.||||:.|....||.:.|::...:.|.....||..||..|.:|:|
Mouse   244 AVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNAERTYIETSIGEGA 308

  Fly   271 -----TEQKTEHHPAVPWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAA 330
                 ::..|      ||.:.|||:|.:||::|:.|.::.:|:.||..|.|.::|..|.::....
Mouse   309 NLASLSKFNT------PWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGL 367

  Fly   331 LSALPYFPMIIFSICLGKLLDSLQAKGKITTTVARKTATSICTLIPGVCLLVLCYIGCRHYEAVS 395
            |||:|:..|.|.....|:|.|.|:::..:|||..||...  |... |:...:|..:|..|.:.|:
Mouse   368 LSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMN--CGGF-GMEATLLLVVGFSHTKGVA 429

  Fly   396 ----VMSVGIVAMGSMFSGFLSNHIDIAPNFAGTLVALTNTAATLPGIVVPLFVGFVTKGNQNIG 456
                |::||.  .|...|||..||:||||.:|..|:.::|...||.|:|.||.||.:|| ::...
Mouse   430 ISFLVLAVGF--SGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTK-HKTRE 491

  Fly   457 AWRIIFGVTIVLFALEFLVFVFLGSGSEQPWNKAGTPKDPEAKDE 501
            .|:.:|.:..::.....:.:....||.:|.|      .|||...|
Mouse   492 EWQNVFLIAALVHYSGVIFYGVFASGEKQDW------ADPENLSE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS3	NP_608572.1	2A0114euk	19..489	CDD:129972	149/483 (31%)
MFS3	NP_608572.1	MFS	100..479	CDD:119392	130/392 (33%)
Slc17a8	NP_892004.1	2A0114euk	88..526	CDD:129972	150/491 (31%)
		MFS	93..515	CDD:119392	142/469 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	576..601
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830