Protein Alignment HSPD1 and Hsp60B

DIOPT Version :10

• Sequence 1: NP_002147.2
• Gene: HSPD1 / 3329
• HGNCID: 5261
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_524925.1
• Gene: Hsp60B / 48572
• FlyBaseID: FBgn0011244
• Length: 648
• Species: Drosophila melanogaster
• Alignment Length: 601
• Identity: 330/601 - (54%)
• Similarity: 434/601 - (72%)
• Gaps: 36/601 - (5%)

Human     7 VFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSP 71
            :||...|.:...:....|.|:|||:||:..||:|::|||:||||||||||||||:||:|:.|.||
  Fly     1 MFRSCVPKAITSSRCFARMYSKDVRFGSGVRAMMIRGVDILADAVAVTMGPKGRSVIVERPWTSP 65

Human    72 KVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGAN 136
            |:||||.|||:||.|||::.|:|||||||||:||||.|||||||||||||:||||||.:|:.|||
  Fly    66 KITKDGFTVARSIALKDQHMNLGAKLVQDVADNTNESAGDGTTTATVLARAIAKEGFNQITMGAN 130

Human   137 PVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITV 201
            |||||||||||||.|..:||:.||.|.|.|||.||||:|||||.|||.:|.:|..|||.:|.|||
  Fly   131 PVEIRRGVMLAVDVVKDKLKEMSKAVETREEIQQVATLSANGDTEIGRLIGEATDKVGPRGTITV 195

Human   202 KDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANA 266
            ||||.|.|||.||:|::||.||:||:|:|:|||.|.||.:|.|::|.|||:.:..||..||.:..
  Fly   196 KDGKRLKDELNIIQGLRFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLSQIVKGLEQSLR 260

Human   267 HRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLT 331
            .|:||:|||||:.||||:.||||:|::||||.|||:|.:|.:||..:.|::.|||..:||::...
  Fly   261 QRRPLIIIAEDISGEALNALVLNKLRLGLQVCAVKSPSYGHHRKELIGDISAATGATIFGDDINY 325

Human   332 LNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQL-DVTTSEYEKEKLNERLA 395
            ..:|:.:..|||:|||.:::||..|||:||.....:|.|||:|.::| :......::::|.:||:
  Fly   326 SKMEEAKLEDLGQVGEAVISKDSTMLLQGKPKTGLLEMRIQQIQDELAEKQIKPEQRDRLRQRLS 390

Human   396 KLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANED 460
            .|:.|||||.:||.|:||||||||||.|||||||||:|||||.|||.|.|||||.|..|...:.|
  Fly   391 ALTKGVAVLHIGGGSEVEVNEKKDRVVDALNATRAAIEEGIVPGGGTAFLRCIPYLQELKTESAD 455

Human   461 QKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVV 525
            .:.|::|:...|::|..|||:||||:|.::|.|::..|.:.|||||..::..:|||||||||||:
  Fly   456 LQKGVDIVCNALRMPCQTIAQNAGVDGPMVVAKVLNGSEDYGYDAMGDEYCRLVEKGIIDPTKVL 520

Human   526 RTALLDAAGVASLLTTAEVVVTEIPKEE-----------KDP----------------------G 557
            |||:.|||||||||:|.|||:|:...::           .|.                      |
  Fly   521 RTAITDAAGVASLLSTTEVVITDSRNDDLLSKLSGAGGGMDDGLDMNMGGLEELAALSGLGGMGG 585

Human   558 MGAMGGMG--GGMGGG 571
            ||.|||||  ||||||
  Fly   586 MGGMGGMGGMGGMGGG 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPD1	NP_002147.2	GroEL	28..548	CDD:239460	309/520 (59%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	309/520 (59%)