Protein Alignment HSPD1 and CCT1

DIOPT Version :10

• Sequence 1: NP_002147.2
• Gene: HSPD1 / 3329
• HGNCID: 5261
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_524450.2
• Gene: CCT1 / 42649
• FlyBaseID: FBgn0003676
• Length: 557
• Species: Drosophila melanogaster
• Alignment Length: 609
• Identity: 124/609 - (20%)
• Similarity: 217/609 - (35%)
• Gaps: 193/609 - (31%)

Human    33 GADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKL 97
            ||..|...:.....:::.|..::||.|...::....|...||.||.|:.:.:::    ::..||:
  Fly    17 GASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEV----EHPAAKV 77

Human    98 VQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPV 162
            :.::|...:||.|||||:..:||..:.|...|.:.:..:|..|..|..:|....   .|..|:.:
  Fly    78 LVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEA---CKYISEHL 139

Human   163 TTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPY 227
            |.|.:             |:|.   |::..:.:    |....|.:..:.|....|..|..  ...
  Fly   140 TAPVD-------------ELGR---DSLINIAK----TSMSSKIIGADAEFFSAMVVDAA--QSV 182

Human   228 FINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAED---VDGEALS----- 284
            .|...:||.     ||             .:.|:.:..||.|.    |.:   :.|.||:
  Fly   183 KITDPRGQA-----AY-------------SIKAINVLKAHGKS----ARESVLIPGYALNCTIAS 225

Human   285 -----------------TLVLNRLKVGLQVV--------AVKAP-------------GFGDN--- 308
                             :|...::|:|:||:        |::|.             |.|.|
  Fly   226 QQMPKKIVNAKIACLDFSLQKTKMKMGVQVLINDPDKLEAIRARELDITKERINMILGTGVNVVL 290

Human   309 ------------------------RKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVI 349
                                    :|:.||.:|.|||.|..  ..|| |::..:..|...|||..
  Fly   291 VSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGAAFI--TSLT-NMDGEESFDASMVGEAA 352

Human   350 ------VTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGG 408
                  :..|:.:|:||...:|                                   .|.:.:.|
  Fly   353 EVAQERICDDELILIKGTKARA-----------------------------------AASIILRG 382

Human   409 TSDVEVNEKKDRVTDALNATRAAVE-EGIVLGGGCALLRCIPALDSLTP--ANEDQKIGIEIIKR 470
            .:|...:|.:..|.|||...:..:| :.:|.||||........|::...  |:.:|....|..|.
  Fly   383 PNDFYCDEMERSVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKS 447

Human   471 TLKIPAMTIAKNAGVEGSLIVEKI--MQSSSE----------VGYDAMAGDFVNMVEKGIIDPTK 523
            .|.|| .|::.||..:.:.:|.|:  ..:||:          .|.|.:.|...:..:.|:::|.
  Fly   448 LLVIP-KTLSVNAAKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPA- 510

Human   524 VVRTALLDAAGVASLLTTAEVVVT 547
                    .:.:.||....|..:|
  Fly   511 --------MSKIKSLKFATEAAIT 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPD1	NP_002147.2	GroEL	28..548	CDD:239460	124/609 (20%)
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	124/609 (20%)