Protein Alignment HSPD1 and CCT3

DIOPT Version :10

• Sequence 1: NP_002147.2
• Gene: HSPD1 / 3329
• HGNCID: 5261
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_650572.2
• Gene: CCT3 / 42029
• FlyBaseID: FBgn0015019
• Length: 544
• Species: Drosophila melanogaster
• Alignment Length: 616
• Identity: 145/616 - (23%)
• Similarity: 237/616 - (38%)
• Gaps: 134/616 - (21%)

Human     7 VFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSP 71
            :|...:|: .||:.:..|...:.|:..      .:|....:||.:...:||:....::....|..
  Fly     1 MFGGQQPI-LVLSQNTKRESGRKVQLE------NIQAGKAIADVIRTCLGPQAMLKMLMDPMGGI 58

Human    72 KVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSI--AKEGFEKISKG 134
            .:|.||..:.:.|.:    ::..||.:.::|...:||.|||||:..|||..:  |.|.|  :.:.
  Fly    59 VMTNDGNAILREITV----QHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPF--LQQQ 117

Human   135 ANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATI--SANGDKEIGNIISDAMKKVGRKG 197
            .:|..|.|....|::.::..|:.|.......::.|::|.:  :..|.|.||. .||...|:....
  Fly   118 IHPTVIIRAYREALEDIVGHLQSQLSIQLDVKDKAKMADVVKACVGTKFIGK-WSDLAVKIALDA 181

Human   198 VITVKDGKTL--NDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPA 260
            |.||    ||  |..||:                                 ..|:.:.::.| |.
  Fly   182 VETV----TLSENGRLEV---------------------------------DIKRYAKVEKI-PG 208

Human   261 LEIANAHRKPLVIIAEDVDGEALSTLVLN----------RLKVGLQVVAVKAPGFGD-NRKNQLK 314
            ..|..:.....|:|.:||....:..|:.|          ..|.|.....|:..|..| .|..|::
  Fly   209 GAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIGEQDFTRMLQIE 273

Human   315 ---------DMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTK----DDAMLLKGKGDKAQ 366
                     |:.......||.|:|::    |:..|.|.|.|...:.:    |:..:.:..|  |.
  Fly   274 EEFVQRICADIIAVKPDLVFTEKGVS----DLAQHYLLKAGITAIRRLRKTDNLRIARACG--AT 332

Human   367 IEKRIQEIIEQLDVTTSE--YEKEKLNERL------AKLSDGVAVLKVGGTSDVEVNEKKDRVTD 423
            |..|.:|:.|: ||.|..  :|.:|:.:..      .|......:|..|.:.|: :||.:..:.|
  Fly   333 IVNRTEELTEK-DVGTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDI-LNETERNLQD 395

Human   424 ALNATRAAV-EEGIVLGGGCALLRCIPALDSLTPANEDQKIG--------IEIIKRTL------- 472
            ||:..|..| |..:|.|||...:.....|      ...|..|        :|||.|||
  Fly   396 ALHVARNLVLEPRLVAGGGAVEMAASQLL------TRKQVKGPYTAVAHALEIIPRTLAQNCGAN 454

Human   473 KIPAMTI--AKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGV 535
            .|.|:|.  ||:|...|..:        ...|.|..:|:.|:|..|.|.:|..|.......|...
  Fly   455 TIRALTALRAKHASHTGDGV--------CAWGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVET 511

Human   536 ASLLTTAEVVVTEIPK----EEKDPGMGAMG 562
            |.||...:.:|:...|    |..:|...|.|
  Fly   512 AILLLRIDDIVSGSKKRGGNEPTNPAAMAQG 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPD1	NP_002147.2	GroEL	28..548	CDD:239460	135/575 (23%)
CCT3	NP_650572.2	chap_CCT_gamma	7..528	CDD:274085	139/594 (23%)