Protein Alignment HSPD1 and CCT5

DIOPT Version :10

• Sequence 1: NP_002147.2
• Gene: HSPD1 / 3329
• HGNCID: 5261
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_523707.1
• Gene: CCT5 / 36308
• FlyBaseID: FBgn0010621
• Length: 542
• Species: Drosophila melanogaster
• Alignment Length: 564
• Identity: 140/564 - (24%)
• Similarity: 226/564 - (40%)
• Gaps: 132/564 - (23%)

Human    33 GADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKL 97
            |.||....:.....:|..:..::||||...|:....|...||.||.|:.|.:::..:.    |||
  Fly    31 GTDAIKTHIMAARQIASTLKTSLGPKGLDKIMVSPDGDVTVTNDGATIMKLMEVDHEI----AKL 91

Human    98 VQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPV 162
            :..::.:.::|.|||||...|||.::.::....|.:|.:|:.|..|..||....|.:|...::|.
  Fly    92 MVQLSQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHPIRIADGFELAAQCAIKQLDAIAQPF 156

Human   163 ----TTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKD--GKTLNDELEIIE----GM 217
                ...|.:.|:| ::..|.| |.|.....|.::....|:.|.|  .|.:|.||..||    |.
  Fly   157 PVDPKNKEPLIQIA-MTTLGSK-IVNKCHRQMAEMAVDAVLNVADIEKKDVNFELIKIETKVGGR 219

Human   218 KFD----RGYISPYFINTSKGQK-----------CEFQ---------------DAYVLLSEKKIS 252
            ..|    :|.|....::.|:..|           |.|:               :.|..|.|.:..
  Fly   220 MEDSMLVKGVIVDKTLSHSQMPKELRNVKLAILTCPFEPPKPKTKHKLDVTSAEDYRALREYEQE 284

Human   253 SIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMA 317
            ....:|..::.|.|   .|.|.....|.||      |.|.:..::.||:..|     ..:::.:|
  Fly   285 KFTQMVKQVKDAGA---TLAICQWGFDDEA------NHLLLQQELPAVRWVG-----GPEIELIA 335

Human   318 IATGGAVFGEEGLTLNLEDVQPHDLGKVGEV----IVTKDDAMLLKGKGDKAQIEKRIQEIIEQL 378
            |||||.:      ....|::.|..||..|.|    ..|..|.||                :||:
  Fly   336 IATGGRI------VPRFEELTPEKLGVAGLVREMAFGTSKDKML----------------VIEE- 377

Human   379 DVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEG-IVLGGGC 442
                            .|.|..|.:...||.:.: :.|.|..:.||:...|:.|::. ||.|||.
  Fly   378 ----------------CKNSKAVTIFLRGGNAMI-IAEAKRSIHDAICVVRSLVKDSRIVYGGGA 425

Human   443 ALLRCIPALDSLTPANE-DQKIGIE-----IIKRTLKIPAMTIAKNAGVE-----GSLIVEKIMQ 496
            |.:.|     ||..|.| ||...:|     .....|:...:.:|:|:|:.     ..|...::.:
  Fly   426 AEISC-----SLAVAKEADQLSTLEQYAFRAFSVALESIPLALAENSGLHPIETLSELKARQVAE 485

Human   497 SSSEVGYDAM-AGD----FVNMVE------KGIIDPTKVVRTAL 529
            ..|.:|.|.| :||    ..|:||      :.|:..|::|:..|
  Fly   486 KKSSLGVDCMLSGDSDMKSHNVVESLHSKKQQILLSTQLVKMIL 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPD1	NP_002147.2	GroEL	28..548	CDD:239460	140/564 (25%)
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	140/564 (25%)