Protein Alignment HSPD1 and Hsp60D

DIOPT Version :10

• Sequence 1: NP_002147.2
• Gene: HSPD1 / 3329
• HGNCID: 5261
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_609656.1
• Gene: Hsp60D / 34763
• FlyBaseID: FBgn0032525
• Length: 558
• Species: Drosophila melanogaster
• Alignment Length: 536
• Identity: 226/536 - (42%)
• Similarity: 356/536 - (66%)
• Gaps: 8/536 - (1%)

Human    24 RAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKD 88
            |.:|.|::|||:||.|::|||::||:|||.|:|||||.|:|||...||::||||:|||.::.|.:
  Fly    14 RTFANDIRFGAEARCLLMQGVNVLANAVATTLGPKGRNVLIEQLLISPRITKDGITVANNVQLGN 78

Human    89 KYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVE-IRRGVMLAVDAVI 152
            :.:::|.:|::...||||.:.||||||||:|||.||.:|...:.:....|: :|.|::....||.
  Fly    79 RRQDMGVQLLRQATNNTNNKVGDGTTTATILARGIACQGMHVLRQSKVNVQLLREGILEGSRAVC 143

Human   153 AELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGM 217
            ..|.:.|:.|.|..::..||.::.|||:.:..:|.|.:.::|..|||.:|:..:..||.:|.||:
  Fly   144 DALGEMSQSVDTIGQVEAVAKVALNGDERLAELIGDIILELGDSGVILLKESHSPFDEAKIQEGI 208

Human   218 KFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEA 282
            ....||.||:|...|  ...|.::..:||:..||..::.|:||||:|....:||:|||::...:.
  Fly   209 TIASGYYSPFFAKQS--HTLELENCLLLLTLAKIDQVEQILPALELARLKERPLLIIAKNFGSDL 271

Human   283 LSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGE 347
            |..||||.|:..:||.|||||.|||.:..:::|:|.||||.:..:..   :|.|:...|||:|.|
  Fly   272 LKILVLNNLQGRVQVCAVKAPSFGDEQCEEMEDIAFATGGHLLEDAS---SLADLSEEDLGEVME 333

Human   348 VIVTKDDAMLLKG-KGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSD 411
            .:|...:..||:. ..::.|::.|||:|.|.:|...::.|.::|..||.:|...:|.:.|||||:
  Fly   334 AVVDAKETHLLQPINVNEEQVQCRIQDIRELIDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSE 398

Human   412 VEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPAN-EDQKIGIEIIKRTLKIP 475
            :||:|:|||..|||:|.|.|:.:|:|.|||.|.|||||.||.|.|.: .:.::|.||:|..|::|
  Fly   399 LEVSERKDRFNDALHAVRVAISDGVVPGGGTAYLRCIPVLDELPPTDIMELQVGREIVKDALRLP 463

Human   476 AMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLT 540
            ..|||:||||:.:.::.::::.|...||||.||:|.::|.:||:|||||:::|:..|||:||||.
  Fly   464 CYTIARNAGVDPNEVLRRVLKGSGNYGYDAAAGEFGDLVVRGIVDPTKVLQSAMTSAAGIASLLA 528

Human   541 TAEVVVTEIPKEEKDP 556
            |.||::|:.|.:.|.|
  Fly   529 TTEVLITKQPTKPKIP 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPD1	NP_002147.2	GroEL	28..548	CDD:239460	220/522 (42%)
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	220/522 (42%)