Protein Alignment HSPD1 and CCT4

DIOPT Version :10

• Sequence 1: NP_002147.2
• Gene: HSPD1 / 3329
• HGNCID: 5261
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_609579.1
• Gene: CCT4 / 34674
• FlyBaseID: FBgn0032444
• Length: 533
• Species: Drosophila melanogaster
• Alignment Length: 560
• Identity: 117/560 - (20%)
• Similarity: 240/560 - (42%)
• Gaps: 86/560 - (15%)

Human    28 KDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKN 92
            ||.....|.|...:|....::||:..::||:|...:|:...|...:|.||.|:.|.:::    .:
  Fly    18 KDKSKPTDVRLSNIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVSITNDGATILKQMNV----LH 78

Human    93 IGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKK 157
            ..||::.:::...:..||||||:..|:|.::.:...:.:.||.:|..|........:..:..||:
  Fly    79 PAAKMLVELSRAQDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSFQRCSNKAVEILKQ 143

Human   158 QSKPVTTP--EEIAQVATISANG------DKEIGNIISDAMKKV---GRKGVITVKDGKTLN--- 208
            .|.|:...  |.:.:.|:.|.|.      ...:..|..||:.||   |::..:.:|:.|.::
  Fly   144 MSTPIELDDRETLIKSASTSLNSKVVSQQSSLLAPIAVDAVLKVTDPGKETSVDLKNIKVISSLG 208

Human   209 ---DELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKP 270
               ::.|:::|:         .|...|.|     .:|...:.:.||..||..:.|.:....|.
  Fly   209 GTVEDTELVDGL---------VFTCRSAG-----SNAPKRIEKAKIGLIQFCISAPKTDMDHN-- 257

Human   271 LVIIAEDVDGEALS-------TLVLNRL----KVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAV 324
             ||::   |..|:.       :.:||.:    |.|..|:.|        :|:.|:| |::.....
  Fly   258 -VIVS---DYAAMDRVLKEERSYILNIVKQIKKSGCNVLLV--------QKSILRD-AVSDLAQH 309

Human   325 FGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEK-RIQEIIEQLDVTTSEYEKE 388
            |.::...:.::||:..|:..|.:.:..:..|.|     |....|. ...:::|::...|:::.|.
  Fly   310 FLDKIKCMVVKDVEREDIEFVCKTLHCRPIASL-----DHFTAENLSSADLVEEVASGTNKFVKI 369

Human   389 KLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVE-EGIVLGGGCALLRCIPALD 452
            ...:.:.:.   |::: ..|::.:.:.|....:.|||...|..|: ...::|||...:.....|.
  Fly   370 TGIQNMGRT---VSII-CRGSNKLVLEEAARSLHDALCVVRCLVKLRAQIVGGGAPEIEMALQLA 430

Human   453 SLTPANEDQKIGIE-----IIKRTLKIPAMTIAKNAGVEGSLIVEKI----MQSSSEVGYDAMAG 508
            :|....|    |::     .....|::...|:|:|||:.....|.::    .|.....|.:...|
  Fly   431 ALAQTVE----GVDAYCFRAFADALEVIPSTLAENAGLNPIATVTELRNRHAQGEKNAGINVRKG 491

Human   509 DFVNMVEKGIIDPTKV-VRTALLDAAGVASLLTTAEVVVT 547
            ...::..:.::.|..| :.:..|....:.|:|...::|.|
  Fly   492 AITDIFAENVVQPLLVSISSITLATETIRSILKIDDIVNT 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPD1	NP_002147.2	GroEL	28..548	CDD:239460	117/560 (21%)
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	116/558 (21%)