Protein Alignment HSPD1 and Hsp60A

DIOPT Version :10

• Sequence 1: NP_002147.2
• Gene: HSPD1 / 3329
• HGNCID: 5261
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_511115.2
• Gene: Hsp60A / 32045
• FlyBaseID: FBgn0015245
• Length: 573
• Species: Drosophila melanogaster
• Alignment Length: 577
• Identity: 426/577 - (73%)
• Similarity: 496/577 - (85%)
• Gaps: 9/577 - (1%)

Human     1 MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIE 65
            |.||| |......:||.||   .|.|||||:||.:.||:||||||:||||||||||||||.||||
  Fly     1 MFRLP-VSLARSSISRQLA---MRGYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIE 61

Human    66 QSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEK 130
            |||||||:|||||||||||:||||::||||||||||||||||||||||||||||||:||||||||
  Fly    62 QSWGSPKITKDGVTVAKSIELKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEK 126

Human   131 ISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGR 195
            ||||||||||||||||||:.|...||..|:||:||||||||||||||||:.|||:||:|||||||
  Fly   127 ISKGANPVEIRRGVMLAVETVKDNLKTMSRPVSTPEEIAQVATISANGDQAIGNLISEAMKKVGR 191

Human   196 KGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPA 260
            .|||||||||||.||||:|||||||||||||||||:|||.|.|||||.:|||||||||:|||:||
  Fly   192 DGVITVKDGKTLTDELEVIEGMKFDRGYISPYFINSSKGAKVEFQDALLLLSEKKISSVQSIIPA 256

Human   261 LEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVF 325
            ||:|||.||||||||||:|||||||||:||||:||||.||||||||||||:.|.|||||:||.||
  Fly   257 LELANAQRKPLVIIAEDIDGEALSTLVVNRLKIGLQVAAVKAPGFGDNRKSTLTDMAIASGGIVF 321

Human   326 GEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKL 390
            |::...:.||||:..|||:||||::||||.:||||||.|..:.:|..:|.:|::.||||||||||
  Fly   322 GDDADLVKLEDVKVSDLGQVGEVVITKDDTLLLKGKGKKDDVLRRANQIKDQIEDTTSEYEKEKL 386

Human   391 NERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLT 455
            .||||:|:.|||:|:|||:|:||||||||||.|||||||||||||||.|||.||||||..|:.:.
  Fly   387 QERLARLASGVALLRVGGSSEVEVNEKKDRVHDALNATRAAVEEGIVPGGGTALLRCIEKLEGVE 451

Human   456 PANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIID 520
            ..|||||:|:||::|.|::|.|||||||||:|:::|.|:...:.:.||||:.|::.|::||||||
  Fly   452 TTNEDQKLGVEIVRRALRMPCMTIAKNAGVDGAMVVAKVENQAGDYGYDALKGEYGNLIEKGIID 516

Human   521 PTKVVRTALLDAAGVASLLTTAEVVVTEIPKEE---KDPGMGAMGGMG--GGMGGGM 572
            ||||||||:.||:||||||||||.||||||||:   ..||||.|||||  |||||.|
  Fly   517 PTKVVRTAITDASGVASLLTTAEAVVTEIPKEDGAPAMPGMGGMGGMGGMGGMGGMM 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPD1	NP_002147.2	GroEL	28..548	CDD:239460	393/519 (76%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	393/519 (76%)