Protein Alignment HSPD1 and CCT2

DIOPT Version :10

• Sequence 1: NP_002147.2
• Gene: HSPD1 / 3329
• HGNCID: 5261
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_572524.1
• Gene: CCT2 / 31838
• FlyBaseID: FBgn0030086
• Length: 535
• Species: Drosophila melanogaster
• Alignment Length: 564
• Identity: 135/564 - (23%)
• Similarity: 238/564 - (42%)
• Gaps: 108/564 - (19%)

Human    36 ARALMLQGVDLLADAVAVTMGPKGRTVII---EQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKL 97
            ||.....|...:.|.|..|:||||...|:   .::.|..:||.||.|:.:::.:    .|..||:
  Fly    23 ARLSSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDGATILRAVGV----DNPAAKI 83

Human    98 VQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEI----RRGVMLAVDAVIAELKKQ 158
            :.|::...:||.|||||:.||||..:.:|..:.:.:..:|..|    |:...:|::|:.|..:..
  Fly    84 LVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWRQATQVALEALTAAAQDN 148

Human   159 SKPVTTPE----EIAQVA--TISA---NGDKE-IGNIISDAMKKVGRKG-----VITVKDGKTLN 208
            |   ::.|    ::..:|  |:|:   :..|: ..|:..||:.::...|     .|..|.|.||.
  Fly   149 S---SSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRLKGSGELKSIQIIKKSGGTLG 210

Human   209 DELEIIEGMKFDR--GYISPYFINTSK----GQKCEFQDAYVLLSEKKISSIQSIVPALEIANAH 267
            |.. :.||...|:  |...|..|..::    ....:.....|..|..|:.|:..|.. ||:|...
  Fly   211 DSF-LDEGFLLDKKPGVHQPQRIENARILIANTPMDTDKIKVFGSSIKVDSLAKIAD-LEMAEKE 273

Human   268 RKPLVIIAEDVDG--EALSTLVLNR---------LKVGLQVVAVKAPGFGDNRKNQLKDMAIATG 321
            :     :.|.||.  :....:.:||         |....:|::::...|     :.::.:|..||
  Fly   274 K-----MKEKVDKILKHKCNVFINRQLIYNYPEQLFADARVMSIEHADF-----DGIERLAYCTG 328

Human   322 GAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLK-GKGDKAQIEKRIQEIIEQLDVTTSEY 385
                                    ||::.|.::..|:| |:.|          :|||:.:.
  Fly   329 ------------------------GEIVSTFENPSLVKLGECD----------VIEQVMIG---- 355

Human   386 EKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEG-IVLGGGCA---LLR 446
            |...|.....||.:...::..|.|..: ::|....:.|||....|.|:|. |:.||||:   :..
  Fly   356 EDTLLRFSGVKLGEACTIVIRGATQQI-LDEADRSLHDALCVLAATVKESRIIFGGGCSEALMAT 419

Human   447 CIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKI----MQSSSEVGYDAMA 507
            .:....:.||..|  .|.||...|.|......||.|||.:.:.:|.::    .|....:|.|...
  Fly   420 AVLKKAAETPGKE--AIAIEAFARALLSLPTAIADNAGYDSAQLVSELRAGHAQGKQTLGLDMEL 482

Human   508 GDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPK 551
            |...::.|.||.:...|.|..|:.|:..|.::...:.::...|:
  Fly   483 GKVADVRELGITESFAVKRQVLMSASEAAEMILRVDNIIRCAPR 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPD1	NP_002147.2	GroEL	28..548	CDD:239460	134/559 (24%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	135/564 (24%)