Protein Alignment TBC1D23 and TBC1D23

DIOPT Version :10

• Sequence 1: NP_608569.1
• Gene: TBC1D23 / 33289
• FlyBaseID: FBgn0031304
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: XP_061509227.1
• Gene: TBC1D23 / 1278218
• VectorBaseID: AGAMI1_000712
• Length: 732
• Species: Anopheles gambiae
• Alignment Length: 738
• Identity: 458/738 - (62%)
• Similarity: 558/738 - (75%)
• Gaps: 63/738 - (8%)

  Fly     1 MEENMWIIELESALLDDCTVNDIYGICQGKALPEALRPDVWQVCLDVRHKSDQMSLFNEIYDLPF 65
            ||:.:|:|||||||.|||||:|||.||.||.||||||.|||||||.||:|.||::.|||||||||
Mosquito     1 MEDGLWLIELESALQDDCTVDDIYAICHGKTLPEALRLDVWQVCLGVRNKPDQLAQFNEIYDLPF 65

  Fly    66 QSQLREDCQRHVDRMGNDEEDKVSVVSDLESIITFYCKNRNLQYEPDNGWIELLLPLFALKLNRS 130
            |:.||.||:..|.::||::|||||||.|||||:|||||||||.|||:|||:||:|||.:|||.||
Mosquito    66 QALLRSDCEEFVSKLGNEDEDKVSVVCDLESILTFYCKNRNLVYEPNNGWVELMLPLLSLKLIRS 130

  Fly   131 DTFNLFESIRDTYIPKGCRPKGNVFHVFRLLLLYHDPELCTLLDTKKITPDLYSLTWFQSLFASC 195
            ||:||||:||||||||||...|.||:|||||||||||||||:||||:||||.|::.|||:||||.
Mosquito   131 DTYNLFEAIRDTYIPKGCSKNGTVFNVFRLLLLYHDPELCTILDTKRITPDCYAMGWFQTLFAST 195

  Fly   196 SSLSVIIAMWDLYFQNADPFMVFFLALIILINGREQILQMRSSSKEEIIKFLSLMPCALEFDDVP 260
            .:|.|:::|||||||.:|||:||||:||:|||.|:|||.|::|:|||:|.||..|||.:|.|||.
Mosquito   196 CTLPVVLSMWDLYFQQSDPFLVFFLSLIVLINQRDQILAMKASTKEELIGFLVNMPCNIEADDVL 260

  Fly   261 DFCSLAQYYALKTPTSFKTDYLKALYGKQNDTPRSQEEANKVSQALCLPVSVYELVENSATEFPV 325
            |||||||||::|||.|||.|.|:.|:|.|.. ..|:.|.:.|||||||||||.||:||::.:.|.
Mosquito   261 DFCSLAQYYSVKTPASFKRDLLQVLFGAQRG-GSSKPEGSVVSQALCLPVSVNELIENASIQNPH 324

  Fly   326 PDAVRFFLVDCRPAEQYNAGHLSTAFHLDCNLMLQEPVAFATAVQGLLTAQRQAIEANSNAGGEH 390
            |:||||||||||||||||:||||||||||.|||||||.||.|||||||.:||.||:|||||||||
Mosquito   325 PEAVRFFLVDCRPAEQYNSGHLSTAFHLDSNLMLQEPEAFQTAVQGLLRSQRNAIDANSNAGGEH 389

  Fly   391 LCFMGSGRVEEDQYTHMVVASFLQKNTHYVSLLTGGYASIHDYFGDQMADCLEDHNARKCLVCQQ 455
            |||:||||:||||||||||||||||||.|||||||||.:||:|||:.|.||||||:..|||:|.:
Mosquito   390 LCFLGSGRLEEDQYTHMVVASFLQKNTKYVSLLTGGYEAIHEYFGEGMVDCLEDHDPLKCLLCNK 454

  Fly   456 ------------------------HNAQQTKSAPLKTST----------------PSSTDLFSKF 480
                                    ::|..:.:..||...                .|:.|||||.
Mosquito   455 EQLRYGGGKSIANNNNPKALNSGANSANSSATNSLKRGNQRSGHTANNNGTAGDRKSTIDLFSKL 519

  Fly   481 SAAMKSKSAEVKGKLLDIIVNPSAN-GGATASGTNGVPSAPVQERHVSAKERNGKRYRNVAPVFS 544
            |.|||:||||||.||:|.|.||:|| .|::.:|..|       |:|||..:|||||||||.||||
Mosquito   520 SLAMKTKSAEVKEKLIDYISNPNANEPGSSRTGNGG-------EKHVSRNDRNGKRYRNVPPVFS 577

  Fly   545 I--DDENEDALDGAGERDDAPLTS----------DGKEIVNLNQYFKTADIINAFKCQEVHMSGY 597
            |  |.|:||.|:.|.......:.|          ..:|||::..:.|..|:|..|||||||::||
Mosquito   578 IGEDQEDEDELNSAASESSLVVRSAKTNSQQQSDPTEEIVSIQSFLKGPDVIRYFKCQEVHLNGY 642

  Fly   598 MYDSHLIITPGQLVVLREL--GRGQAQIMVRRPLASIVKITAKKRHRDLITFKYGFPDGDGLLIT 660
            ||||:|::|...::|||||  .|.:|:|:|||.|.||||||||||||||||||||:|:.:.|:||
Mosquito   643 MYDSYLLVTAKHMIVLRELETRRDRARIIVRRQLQSIVKITAKKRHRDLITFKYGYPEEENLVIT 707

  Fly   661 DMDRFLIPNAAEVTALISRLIVQ 683
            ||||||||||:|||.||||.|::
Mosquito   708 DMDRFLIPNASEVTDLISRHIIK 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D23	NP_608569.1	RabGAP-TBC	34..233	CDD:459855	143/198 (72%)
		RHOD	327..>373	CDD:444705	40/45 (89%)
		TBC1D23_C-like	572..684	CDD:412053	73/114 (64%)
TBC1D23	XP_061509227.1	None