DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtRNApol and MGP3

DIOPT Version :9

Sequence 1:	NP_001259853.1	Gene:	mtRNApol / 33285	FlyBaseID:	FBgn0261938	Length:	1369	Species:	Drosophila melanogaster
Sequence 2:	NP_001185355.1	Gene:	MGP3 / 843232	AraportID:	AT1G68990	Length:	983	Species:	Arabidopsis thaliana

Alignment Length:	1112	Identity:	345/1112 - (31%)
Similarity:	526/1112 - (47%)	Gaps:	240/1112 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 RGKVRKSSLPHMSEGLITIDLYNILLHGYAGKGSFDRAQ-EVFKLIEEDGLSFNEQTYAAIFECL 400
            ||.:...:|..:..|| :|:..|.:    .|..||...| .||            :.||...:.:
plant    33 RGILSSVNLSGVRNGL-SINPVNEM----GGLSSFRHGQCYVF------------EGYATAAQAI 80

  Fly   401 GRLEPDEEN--HQYISEYVSKAEKEGFSLNQIMDRSKFVADQRDIALDAIRRLRPDFKPVYVPPQ 463
            ...:|::|:  ...::|.:::.|||                        ..|:|...:...:||
plant    81 DSTDPEDESSGSDEVNELITEMEKE------------------------TERIRKKARLAAIPP- 120

  Fly   464 LGYDNELLDHLNEHVIPVGAKKEPGKADYAIMNSKRGYTAAQLEQLAREQLKIELDGSITIKSIE 528
                        :.||                   .|..|.:...|.:.|:|:|.:      ..|
plant   121 ------------KRVI-------------------AGMGAQKFYMLKQRQVKMETE------EWE 148

  Fly   529 KSKEFANSEKCRELL---------------KELEDTWRKQISAAIVRDLNTLRAQVRFKPHGFMN 578
            ::     :.:|||:|               |.|...|.:.:..||..||:|.:.:     .|.:.
plant   149 RA-----ARECREILADMCEQKLAPNLPYMKSLFLGWFEPVRNAIQDDLDTFKIK-----KGKIP 203

  Fly   579 YYTYLKTLDASHFADILIKELYKL----AEGSETFSPTVG-----QLYKELGQKVQQRYQIE--- 631
            |..:::.|.|...|.|.:.::..|    |||       ||     ....::|:.|:|..:|.
plant   204 YAPFMEQLPADKMAVITMHKMMGLLMTNAEG-------VGIVKLVNAATQIGEAVEQEVRINSFL 261

  Fly   632 QKKH--NGTLEKIG--------EIYSSYCELWGSG----MSQDNTRQAWQRLVYEQRESGPSMDL 682
            |||:  |.|.:.|.        ||.:...|.....    |.::..||.  :.:..:.:|..
plant   262 QKKNKKNATDKTINTEAENVSEEIVAKETEKARKQVTVLMEKNKLRQV--KALVRKHDSFK---- 320

  Fly   683 LEVPWPSNVLTGVGRFLYNILMRDIKIDAHIMRQKSKSKAAAQPQNLLPAFYTLFR--------N 739
               ||.......||..|..:||.:..|      |....:....|.::.|||...||        .
plant   321 ---PWGQEAQVKVGARLIQLLMENAYI------QPPAEQFDDGPPDIRPAFKQNFRTVTLENTKT 376

  Fly   740 QGRFVKEEVKP------HPVLSRLFRASRQQTLTFDSNLVPMLCPPQPWSTPHNGGYLLNKTELI 798
            ..|:...|..|      ...:||:...:|...:.:    :|||.|||.|:....|.:....:.::
plant   377 SRRYGCIECDPLVLKGLDKSVSRIVDYARHMVIPY----LPMLIPPQNWTGYDQGAHFFLPSYVM 437

  Fly   799 RLPHQAIQQWDRIMASNPQHLYPALDSLNQLASVPWRVNTQLLDVIIKVFQNGGDV-----KLDV 858
            | .|.|.||...:..:..:.|.|..::|:.|.:..|::|.::|.::.:::.|||.:     :.||
plant   438 R-THGAKQQRTVMKRTPKEQLEPVYEALDTLGNTKWKINKKVLSLVDRIWANGGRIGGLVDREDV 501

  Fly   859 PQPPSSLPPLPTLPAKDAEGNATSSEDRAKQFRDKLGHRRKQ-AEMYSLWCDALYRLSLAQHYRD 922
                    |:|..|.::       .:::.|.:|.:.....|| .|.:|..||...:|.:|:..:|
plant   502 --------PIPEEPERE-------DQEKFKNWRWESKKAIKQNNERHSQRCDIELKLEVARKMKD 551

  Fly   923 KV-FWLPHNMDFRGRVYPVPPHLNHLGSDLARSMLIFDQAQPLGVDGLSWLKLHCINL-TGLKKR 985
            :. |:.|||:|||||.||:.|:||||||||.|.:|.|.:.:|||..||.|||:|..|| .|...:
plant   552 EEGFYYPHNVDFRGRAYPIHPYLNHLGSDLCRGILEFCEGKPLGKSGLRWLKIHIANLYAGGVDK 616

  Fly   986 DSVRERLLYAEEIMPDILDSADNPLTGRMWWSKSDEPWQTLACCMEIANVHRCPDPAAYLSRFPI 1050
            .:..:|:.:.|..:.||.||:|.||.|:.||..:::|:|.||.|:.::...|.|.|.|.:|..||
plant   617 LAYEDRIAFTESHLEDIFDSSDRPLEGKRWWLNAEDPFQCLAACINLSEALRSPFPEAAISHIPI 681

  Fly  1051 HQDGSCNGLQHYAALGRDEAGARSVNLAPSAIPQDVYSAVAALVEKSRKADAQ-------NGLHV 1108
            ||||||||||||||||||:.||.:|||.....|.|||:.:||.|.|..:.||:       |..:
plant   682 HQDGSCNGLQHYAALGRDKLGADAVNLVTGEKPADVYTEIAARVLKIMQQDAEEDPETFPNATY- 745

  Fly  1109 AEALAGFVRRKVIKQTVMTTVYGVTRYGARLQIARQLKDIDDFPKD-WVWPASTYLTTKTFESLR 1172
            |:.:...|.||::||||||:|||||..|||.||.::||:...|..| ..:.||.|....|.::|.
plant   746 AKLMLDQVDRKLVKQTVMTSVYGVTYSGARDQIKKRLKERGTFEDDSLTFHASCYAAKITLKALE 810

  Fly  1173 EMFTSTREIQDWFTECARLISGVCSQN--VEWVTPLGLPVVQPYNRQEMKHSPRSGFKVSANMPM 1235
            |||.:.|.|:.||.:||::|:   |:|  |.|.||||||||||| |:..:|..::..:|     :
plant   811 EMFEAARAIKSWFGDCAKIIA---SENNAVCWTTPLGLPVVQPY-RKPGRHLVKTTLQV-----L 866

  Fly  1236 DL-YERPNIL--KQKNAFPPNFIHSLDSSHMMLTSLHCERQGITFVSVHDCFWTHANTVPELNRM 1297
            .| .|...::  :|..||.||||||||.||||:|::.|.|.|::|..|||.|||||..|..:|.:
plant   867 TLSRETDKVMARRQMTAFAPNFIHSLDGSHMMMTAVACNRAGLSFAGVHDSFWTHACDVDVMNTI 931

  Fly  1298 CREQFVALHSQPILEQLSEFMRHTYSFKDSDFINDGSVEDLSKRQLNRILKQMPQKGDFDLRNVL 1362
            .||:||.|:.:||||.|.|..:.  ||.|..|                  ..:|::||||||.||
plant   932 LREKFVELYEKPILENLLESFQK--SFPDISF------------------PPLPERGDFDLRKVL 976

  Fly  1363 DSVYFFS 1369
            :|.|||:
plant   977 ESTYFFN 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtRNApol	NP_001259853.1	RPO41	286..1369	CDD:227439	344/1110 (31%)
		PPR repeat	314..342	CDD:276811	2/4 (50%)
		PPR repeat	355..384	CDD:276811	8/29 (28%)
		PPR	358..386	CDD:279828	7/28 (25%)
		RPOL_N	513..829	CDD:291372	82/370 (22%)
		RNA_pol	962..1368	CDD:279308	185/419 (44%)
MGP3	NP_001185355.1	PHA00452	135..982	CDD:222797	314/934 (34%)
		RPOL_N	138..468	CDD:291372	82/372 (22%)
		RNA_pol	592..982	CDD:279308	185/419 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	336	1.000	Domainoid score	I251
eggNOG	1	0.900	-	-		E1_COG5108
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	466	1.000	Inparanoid score	I359
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D135329at2759
OrthoFinder	1	1.000	-	-		FOG0003398
OrthoInspector	1	1.000	-	-		otm2973
orthoMCL	1	0.900	-	-		OOG6_101824
Panther	1	1.100	-	-	O	PTHR10102
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830