DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtRNApol and AT5G15700

DIOPT Version :9

Sequence 1:	NP_001259853.1	Gene:	mtRNApol / 33285	FlyBaseID:	FBgn0261938	Length:	1369	Species:	Drosophila melanogaster
Sequence 2:	NP_001190318.1	Gene:	AT5G15700 / 831424	AraportID:	AT5G15700	Length:	1051	Species:	Arabidopsis thaliana

Alignment Length:	971	Identity:	334/971 - (34%)
Similarity:	486/971 - (50%)	Gaps:	156/971 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   484 KKEPGKADYAIMNS-KRGYTAAQLEQLAREQLKIELDGSITIKSIEKSKEFANSEKCRELLKE-- 545
            ::|..|::..:..: .||||:...|::....::.|.:....:|.::|.|: ..|.:...:.|:
plant   103 REEFSKSERCLSGTLARGYTSVAEEEVLSTDVEEEPEVDELLKEMKKEKK-RESHRSWRMKKQDQ 166

  Fly   546 -------LEDTWRKQI---------SAAIVRDLNTLRAQVRFKPHGFMNYYTYLKTLDASHF--- 591
                   .::.||:|:         :||...:|.|...:.:..|:     ..|:|:|....|
plant   167 FGMGRTKFQNLWRRQVKIETEEWERAAAEYMELLTDMCEQKLAPN-----LPYVKSLFLGWFEPL 226

  Fly   592 ADILIK--ELYKLAEGSETFSPTVGQLYKE-------------------------------LGQK 623
            .|.:.|  |||:|.:...|::..:.||..:                               :|..
plant   227 RDAIAKDQELYRLGKSKATYAHYLDQLPADKISVITMHKLMGHLMTGGDNGCVKVVHAACTVGDA 291

  Fly   624 VQQRYQI----EQKKHNGTLEKIGEIYSSYCELWGSGMSQDNTRQAWQRLVYEQRESG-----PS 679
            ::|..:|    ::||.....|:.|.:     |...|...||..|:....|:.:|:.|.     .|
plant   292 IEQEIRICTFLDKKKKGDDNEESGGV-----ENETSMKEQDKLRKKVNELIKKQKLSAVRKILQS 351

  Fly   680 MDLLEVPWPSNVLTGVGRFLYNILMRDIKIDAHIMRQKSKSKAAAQPQNL---LPAFYTLFR--- 738
            .|..: ||.::|...||..|..:|:|...|         :|.|..|..:|   .|||...|:
plant   352 HDYTK-PWIADVRAKVGSRLIELLVRTAYI---------QSPADQQDNDLPDVRPAFVHTFKVAK 406

  Fly   739 ---NQGR-FVKEEVKPHPVLSRLFRASRQQTLTFDSNLVPMLCPPQPWSTPHNGGYLLNKTELIR 799
               |.|| :...|..| .|...|.::.|...:.:    :|||.||..||....|.||. .|..|.
plant   407 GSMNSGRKYGVIECDP-LVRKGLEKSGRYAVMPY----MPMLVPPLKWSGYDKGAYLF-LTSYIM 465

  Fly   800 LPHQAIQQWDRIMASNPQHLYPALDSLNQLASVPWRVNTQLLDVIIKVFQNGGDV-----KLDVP 859
            ..|.|.||.:.:.::....|.|..::|:.|.|..||||.::|.|:.:::.:||.|     :.|||
plant   466 KTHGAKQQREALKSAPKGQLQPVFEALDTLGSTKWRVNKRVLTVVDRIWSSGGCVADMVDRSDVP 530

  Fly   860 QPPSSLPPLPTLPAKDAEGNATSSEDRAKQFRDKLGHRRK-QAEMYSLWCDALYRLSLAQHYRD- 922
                 ||..|.          |..|...|:::.::...:| .:|.:|..||...:||:|:..:|
plant   531 -----LPEKPD----------TEDEGILKKWKWEVKSAKKVNSERHSQRCDTELKLSVARKMKDE 580

  Fly   923 KVFWLPHNMDFRGRVYPVPPHLNHLGSDLARSMLIFDQAQPLGVDGLSWLKLHCINL-TGLKKRD 986
            :.|:.|||||||||.||:|||||||||||.|.:|.|.:.:|:|:.||.|||:|..|| .|...:.
plant   581 EAFYYPHNMDFRGRAYPMPPHLNHLGSDLCRGVLEFAEGRPMGISGLRWLKIHLANLYAGGVDKL 645

  Fly   987 SVRERLLYAEEIMPDILDSADNPLTGRMWWSKSDEPWQTLACCMEIANVHRCPDPAAYLSRFPIH 1051
            |:..||.:.|..:.||.||||.||.|..||.::::|:|.||.|:.:....|.|.|...||..|||
plant   646 SLDGRLAFTENHLDDIFDSADRPLEGSRWWLQAEDPFQCLAVCISLTEALRSPSPETVLSHIPIH 710

  Fly  1052 QDGSCNGLQHYAALGRDEAGARSVNLAPSAIPQDVYSAVAALVEKSRKADAQNGLHV------AE 1110
            |||||||||||||||||..||.:|||.....|.||||.:|..|....:.||.....|      |.
plant   711 QDGSCNGLQHYAALGRDTLGAEAVNLVAGEKPADVYSGIATRVLDIMRRDADRDPEVFPEALRAR 775

  Fly  1111 ALAGFVRRKVIKQTVMTTVYGVTRYGARLQIARQLKDIDDF-PKDWVWPASTYLTTKTFESLREM 1174
            .|...|.||::||||||:|||||..|||.||.|:||:..|| .:..|:.|:.|....|..::.||
plant   776 KLLNQVDRKLVKQTVMTSVYGVTYIGARDQIKRRLKERSDFGDEKEVFGAACYAAKVTLAAIDEM 840

  Fly  1175 FTSTREIQDWFTECARLISGVCSQNVEWVTPLGLPVVQPYNRQEMKHSPRSGFKVSANMPMDLYE 1239
            |.:.|.|..||.|||::|:.. ::.|.|.|||||||||||::...|....|...:|.....|
plant   841 FQAARAIMRWFGECAKIIASE-NETVRWTTPLGLPVVQPYHQMGTKLVKTSLQTLSLQHETD--- 901

  Fly  1240 RPNILKQKNAFPPNFIHSLDSSHMMLTSLHCERQGITFVSVHDCFWTHANTVPELNRMCREQFVA 1304
            :..:.:|:.|||||||||||.||||:|::.|:|.|:.|..|||.|||||..|.:||.:.||:||.
plant   902 QVIVRRQRTAFPPNFIHSLDGSHMMMTAVACKRAGVCFAGVHDSFWTHACDVDKLNIILREKFVE 966

  Fly  1305 LHSQPILEQLSEFMRHTYSFKDSDFINDGSVEDLSKRQLNRILKQMPQKGDFDLR-NVLDS 1364
            |:||||||.|.|....  ||...||                  ..:|::||.||: |::.:
plant   967 LYSQPILENLLESFEQ--SFPHLDF------------------PPLPERGDLDLKVNIVST 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtRNApol	NP_001259853.1	RPO41	286..1369	CDD:227439	334/971 (34%)
		PPR repeat	314..342	CDD:276811
		PPR repeat	355..384	CDD:276811
		PPR	358..386	CDD:279828
		RPOL_N	513..829	CDD:291372	88/388 (23%)
		RNA_pol	962..1368	CDD:279308	184/412 (45%)
AT5G15700	NP_001190318.1	PHA00452	174..1000	CDD:222797	318/890 (36%)
		RPOL_N	180..496	CDD:291372	80/341 (23%)
		RNA_pol	620..1001	CDD:279308	182/404 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	336	1.000	Domainoid score	I251
eggNOG	1	0.900	-	-		E1_COG5108
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	466	1.000	Inparanoid score	I359
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D135329at2759
OrthoFinder	1	1.000	-	-		FOG0003398
OrthoInspector	1	1.000	-	-		otm2973
orthoMCL	1	0.900	-	-		OOG6_101824
Panther	1	1.100	-	-	O	PTHR10102
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830