DRSC/TRiP Functional Genomics Resources

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Protein Alignment mtRNApol and POLRMT

DIOPT Version :9

Sequence 1:NP_001259853.1 Gene:mtRNApol / 33285 FlyBaseID:FBgn0261938 Length:1369 Species:Drosophila melanogaster
Sequence 2:XP_005259637.3 Gene:POLRMT / 5442 HGNCID:9200 Length:1237 Species:Homo sapiens


Alignment Length:1351 Identity:505/1351 - (37%)
Similarity:726/1351 - (53%) Gaps:179/1351 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 MPAGAITAKTTTTTTRTQTTTPTQTDAVAQAKKKRLRKPRYAKYVELLEVTEQAISERRSRVKRL 124
            :|....||.......|:.:.:|.:.|   |.::|..      .:||||||.:       :||::|
Human    25 LPGKEGTAGGVCGPRRSSSASPQEQD---QDRRKDW------GHVELLEVLQ-------ARVRQL 73

  Fly   125 KSKKLADFIHKAQQQILERRAREDRKD--KKTKCVLDLAQRQPVEYQKIDMEALDGSILESGVYD 187
            :::.:::.:             .:|.|  :..:|.......||.  :|:.|.|.|.:.:..|   
Human    74 QAESVSEVV-------------VNRVDVARLPECGSGDGSLQPP--RKVQMGAKDATPVPCG--- 120

  Fly   188 DRPMLFFGKDEYTKQVIANPEEVQNILKSFQ------NFRDIIESMEND-----QHEADFGLSTT 241
             |......||:.|:|:     .:|.:....|      .|:.:...::.:     :..|......|
Human   121 -RWAKILEKDKRTQQM-----RMQRLKAKLQMPFQSGEFKALTRRLQVEPRLLSKQMAGCLEDCT 179

  Fly   242 KVHPEEHEMLDPFEAIEPYISPLDKSKRSVTTVAVPNASAVTTKSKKRFKSKVHVNEEQERLAKQ 306
            :..||               ||.::....:...|....|....::.....|:..::.:|:||.  
Human   180 RQAPE---------------SPWEEQLARLLQEAPGKLSLDVEQAPSGQHSQAQLSGQQQRLL-- 227

  Fly   307 RALHINLNTYLNVCVSANMLNRALSTIIAYRGKVRKSSLPHMSEGLITIDLYNILLHGYAGKGSF 371
                    .:...|:..:.|..|...::.:.|:.:|..       |:|:|:||.::.|:|.:|:|
Human   228 --------AFFKCCLLTDQLPLAHHLLVVHHGQRQKRK-------LLTLDMYNAVMLGWARQGAF 277

  Fly   372 DRAQEVFKLIEEDGLSFNEQTYAAIFECLGRLEPDEENHQYISEYVSKAEKEGFSLNQIMDRSKF 436
            .....|..::::.||:.:..:|||..:|:||.:.|...   |...:.:..:||..|..:......
Human   278 KELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGT---IERCLEQMSQEGLKLQALFTAVLL 339

  Fly   437 VADQRDIALDAIRRLRPDFK-PVYVPPQLGYDNELLDHLNEHVIPVGAKKEPGKADYAIMNSKRG 500
            ..:.|...|.|:.:::|.|. |..:||.:.....|.|        |.||  .|:..|    .|..
Human   340 SEEDRATVLKAVHKVKPTFSLPPQLPPPVNTSKLLRD--------VYAK--DGRVSY----PKLH 390

  Fly   501 YTAAQLEQLAREQLKIELDGSITIKSIEK----SKEFANSEKCRELLKELEDTWRKQISAAIVRD 561
            .....|:.|..:||.:||...:.:.|:||    |||..::   |:.||.|.|.|.|.:..|:...
Human   391 LPLKTLQCLFEKQLHMELASRVCVVSVEKPTLPSKEVKHA---RKTLKTLRDQWEKALCRALRET 452

  Fly   562 LNTLRAQVRFKPHGFMNYYTYLKTLDASHFADILIKELYKLAEGSETFSPTVGQLYKELGQKVQQ 626
            .|.|..:|.   .|..:.|.:|..||......:|::.|..|....|:|:    .|.:||..:...
Human   453 KNRLEREVY---EGRFSLYPFLCLLDEREVVRMLLQVLQALPAQGESFT----TLARELSARTFS 510

  Fly   627 RYQIEQKKHNGTLEKIGEIYSSYCELWGSGMSQDN---TRQAWQRLVYEQRESGPSMDLLEVPWP 688
            |:.:::::.:|.::.:...|..|..|..|......   .||.|:.|       |....|.|.|||
Human   511 RHVVQRQRVSGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEEL-------GAPEALREQPWP 568

  Fly   689 SNVLTGVGRFLYNILMRDIKIDAHIMRQKSKSKAAAQPQNLLPAFYTL--FRNQGRFVKE--EVK 749
            ..|...:|:.|..:|::..::...:.:....|:       |:|..|.:  |||    |::  .:|
Human   569 LPVQMELGKLLAEMLVQATQMPCSLDKPHRSSR-------LVPVLYHVYSFRN----VQQIGILK 622

  Fly   750 PHPVLSRLFRASRQQTLTFDSNLVPMLCPPQPWSTPHNGGYLLNKTELIRLPHQAIQQWDRIMAS 814
            |||...:|...:.:.||||::..|||||||.||::||:|.:||:.|:|:|....|.|..:.:...
Human   623 PHPAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTKLMRTVEGATQHQELLETC 687

  Fly   815 NPQHLYPALDSLNQLASVPWRVNTQLLDVIIKVFQNGGDVKLDVPQPPSSLP-------PLPTLP 872
            .|..|:.|||:|.||.:..||||.::||:::::||..|..:|.||.|||..|       |....|
Human   688 PPTALHGALDALTQLGNCAWRVNGRVLDLVLQLFQAKGCPQLGVPAPPSEAPQPPEAHLPHSAAP 752

  Fly   873 AKDAEGNATSSEDRAKQFRDKLGHRRKQA-EMYSLWCDALYRLSLAQHYRDKVFWLPHNMDFRGR 936
            |:.||            .|.:|.|.:|.| ||:||..:||||||||||.||:|||||||||||||
Human   753 ARKAE------------LRRELAHCQKVAREMHSLRAEALYRLSLAQHLRDRVFWLPHNMDFRGR 805

  Fly   937 VYPVPPHLNHLGSDLARSMLIFDQAQPLGVDGLSWLKLHCINLTGLKKRDSVRERLLYAEEIMPD 1001
            .||.|||.||||||:||::|.|.|.:|||..||.|||:|.:||||||||:.:|:||.:|||:|.|
Human   806 TYPCPPHFNHLGSDVARALLEFAQGRPLGPHGLDWLKIHLVNLTGLKKREPLRKRLAFAEEVMDD 870

  Fly  1002 ILDSADNPLTGRMWWSKSDEPWQTLACCMEIANVHRCPDPAAYLSRFPIHQDGSCNGLQHYAALG 1066
            ||||||.|||||.||..::|||||||||||:||..|..|||||:|..|:||||||||||||||||
Human   871 ILDSADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYVSHLPVHQDGSCNGLQHYAALG 935

  Fly  1067 RDEAGARSVNLAPSAIPQDVYSAVAALVEKSRKADAQNGLHVAEALAGFVRRKVIKQTVMTTVYG 1131
            ||..||.||||.||.:||||||.|||.||..|:.|||.|:.||:.|.||:.|||:||||||.|||
Human   936 RDSVGAASVNLEPSDVPQDVYSGVAAQVEVFRRQDAQRGMRVAQVLEGFITRKVVKQTVMTVVYG 1000

  Fly  1132 VTRYGARLQIARQLKDIDDFPKDWVWPASTYLTTKTFESLREMFTSTREIQDWFTECARLISGVC 1196
            |||||.||||.::|:::.|||:::||.||.||..:.|:||:|||:.||.||.|.||.|||||.:.
Human  1001 VTRYGGRLQIEKRLRELSDFPQEFVWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMG 1065

  Fly  1197 SQNVEWVTPLGLPVVQPYNRQEMKHSPRSGFK-VSANMPMDLYERPNILKQKNAFPPNFIHSLDS 1260
            |. ||||||||:||:|||...........|.: ::.....|:..:||..||||.|||||||||||
Human  1066 SV-VEWVTPLGVPVIQPYRLDSKVKQIGGGIQSITYTHNGDISRKPNTRKQKNGFPPNFIHSLDS 1129

  Fly  1261 SHMMLTSLH-------CERQGITFVSVHDCFWTHANTVPELNRMCREQFVALHSQPILEQLSEFM 1318
            ||||||:||       |.|:|:||||||||:||||..|..:|::||||||.|||:|||:.||.|:
Human  1130 SHMMLTALHCYRSPPLCHRKGLTFVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFL 1194

  Fly  1319 RHTYSFKDSDFINDGSVEDLSKRQLNRILKQMPQKGDFDLRNVLDSVYFFS 1369
            ...:..:....        |...||...|:.:|:.|.|||..|..|.||||
Human  1195 VKRFCSEPQKI--------LEASQLKETLQAVPKPGAFDLEQVKRSTYFFS 1237

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mtRNApolNP_001259853.1 RPO41 286..1369 CDD:227439 460/1110 (41%)
PPR repeat 314..342 CDD:276811 4/27 (15%)
PPR repeat 355..384 CDD:276811 8/28 (29%)
PPR 358..386 CDD:279828 7/27 (26%)
RPOL_N 513..829 CDD:291372 96/326 (29%)
RNA_pol 962..1368 CDD:279308 240/413 (58%)
POLRMTXP_005259637.3 PPR repeat 261..290 CDD:276811 8/28 (29%)
PPR repeat 296..323 CDD:276811 8/29 (28%)
RPOL_N 432..704 CDD:317144 87/296 (29%)
RNA_pol 831..1236 CDD:307200 240/413 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158838
Domainoid 1 1.000 497 1.000 Domainoid score I355
eggNOG 1 0.900 - - E1_COG5108
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H37996
Inparanoid 1 1.050 801 1.000 Inparanoid score I505
Isobase 1 0.950 - 0 Normalized mean entropy S2671
OMA 1 1.010 - - QHG47603
OrthoDB 1 1.010 - - D135329at2759
OrthoFinder 1 1.000 - - FOG0003398
OrthoInspector 1 1.000 - - oto91826
orthoMCL 1 0.900 - - OOG6_101824
Panther 1 1.100 - - LDO PTHR10102
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1209
SonicParanoid 1 1.000 - - X2294
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1615.790

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