Protein Alignment PolrMT and Polrmt

DIOPT Version :10

• Sequence 1: NP_608565.1
• Gene: PolrMT / 33285
• FlyBaseID: FBgn0261938
• Length: 1369
• Species: Drosophila melanogaster
• Sequence 2: XP_030100878.1
• Gene: Polrmt / 216151
• MGIID: 1915843
• Length: 1237
• Species: Mus musculus
• Alignment Length: 1442
• Identity: 519/1442 - (35%)
• Similarity: 731/1442 - (50%)
• Gaps: 282/1442 - (19%)

  Fly     5 LSANR----AAAVQKALRVPPTAHPTTTTATTTTVCCGCGIAPSNFVHYQQYYQMLYRQMPAGAI 65
            :||.|    ||.:.:.||.|....|.:...|....|
Mouse     1 MSALRWTRSAAGLGRVLRSPGPHRPPSEEGTFGGFC----------------------------- 36

  Fly    66 TAKTTTTTTRTQTTTPTQTDAVAQAKKKRLRKPRYAKYVELLEVTEQAISERRS------RVKRL 124
                  ::.|:...:|.:...:           |...:.|||||.|..:.:.|:      |||::
Mouse    37 ------SSRRSSAASPREQHVL-----------REWGHAELLEVLEARVRQLRAEGTPEMRVKKV 84

  Fly   125 K--------SKKLADFIHKAQQQILERRAREDRKDKKTKCVLDLAQ------RQPVEYQKIDMEA 175
            :        |.:.|..: :|::::.:||.:|..:.|:.     |.|      ::|    ||..:.
Mouse    85 QVDRPPQGHSSRWAQKL-EAEKRVKQRRQKEVDQQKQA-----LTQEFWTLHKEP----KIWNKK 139

  Fly   176 LDGSILESGVYDDRPMLFFGKDEYTKQVIANPEEVQNILKSFQNFRDIIESMENDQHEADFGLST 240
            |.|.:..|                .|....|.||.|..
Mouse   140 LAGYLQPS----------------KKGTPTNSEEKQLA--------------------------- 161

  Fly   241 TKVHPEEHEMLDPFEAIEPYISPLDKSKRSVTTVAVPNASAVTTKSKKRFKSKVHVNEEQERLAK 305
                          :|::..:..|  |.|....:|...|.||               |.|..:.:
Mouse   162 --------------QALQAALGRL--SSREAEALARKKAKAV---------------EAQILVLQ 195

  Fly   306 QRALHINLNTYLNVCVSANMLNRALSTIIAYRGKVRKSSLPHMSEG----LITIDLYNILLHGYA 366
            |:.|     .:...||....:..|...::.           |.:.|    ::|:.:||.::.|:|
Mouse   196 QKFL-----AFFECCVCTGQVPLAHHVLVT-----------HHNNGDRQQVLTLHMYNTVMLGWA 244

  Fly   367 GKGSFDRAQEVFKLIEEDGLSFNEQTYAAIFECLGRLEPDEENHQYISEYVSKAEKEGFSLNQIM 431
            .||||.....||.::::.|||.:..:|||..:|:||.:.|...   |...:.:..:|||....:.
Mouse   245 RKGSFRELVYVFLMLKDAGLSPDLCSYAAALQCMGRRDQDVRT---IQRCLKQMMEEGFQPQLLF 306

  Fly   432 DRSKFVADQRDIALDAIRRLRPDFKPVYVPPQLGYDNELLDHLNEHVIPVGAKKEPGKADYAIMN 496
            .......:.|...|.|:.:..|.|:|   |||..      ..:|...:......:.|...|
Mouse   307 TDLVLEEEDRAALLRAVVKAEPAFRP---PPQAP------SPVNTSTLLKDIYSKEGPVSY---- 358

  Fly   497 SKRGYTAAQLEQLAREQLKIELDGSITIKSIEK----SKEFANSEKCRELLKELEDTWRKQISAA 557
            .|.......|:.|..:||.:||..|:.::|:||    |||..   :.|:.|:.|.:.|..:
Mouse   359 PKLHLPLDTLQDLFYQQLHVELSSSVCVQSVEKAPVMSKEVI---EARKTLQALREQWEVE---- 416

  Fly   558 IVRDLNTLRAQV-RFKPHGFMNYYTYLKTLDASHFADILIKELYKL-AEGSETFSPTVGQLYKEL 620
            ::|.|...:|.: |....|....|.:|..|....|..||::.|..| |:|    .|.: ||...|
Mouse   417 LLRVLRETKATMGRQAYEGQPTLYPFLCLLSEGEFVSILMQVLKVLPAQG----EPLI-QLAHNL 476

  Fly   621 GQKVQQRYQIEQKKHNGTLEKIGEIYSSYCELWGSG--MSQDNTRQAWQRLVYEQRESGPSMDLL 683
            |.:|..|:.::||:....::|:|:.||.|.:|..|.  ::....|:.|:.|       ||.....
Mouse   477 GLRVLNRHLVKQKQVTNHVQKLGQRYSQYLQLLASDTQVAPCLPREYWESL-------GPLEAPA 534

  Fly   684 EVPWPSNVLTGVGRFLYNILMRDIKIDAHIMRQKSKSKAAAQ-PQNLLPAFYTLFRNQGRFVKEE 747
            :.||...||..:|:.|..:|::.:        |..:|.||.| .|..:|..|.::..:.......
Mouse   535 QQPWSVPVLLQLGKQLAELLVQAV--------QMPRSLAARQGAQRSIPVLYHVYSFRSYRQVGI 591

  Fly   748 VKPHPVLSRLFRASRQQTLTFDSNLVPMLCPPQPWSTPHNGGYLLNKTELIRLPHQAIQQWDRIM 812
            :||||..:.|...:.:.||||::..|||||||.||::.|:|.|||:.|:|:|......|....:.
Mouse   592 LKPHPAFTHLLETAAEPTLTFETTEVPMLCPPLPWTSLHSGAYLLSSTKLMRATEGTTQHQRLLE 656

  Fly   813 ASNPQHLYPALDSLNQLASVPWRVNTQLLDVIIKVFQNGGDVKLDVPQPPSSLPPLPT---LPAK 874
            ...|..|:..||:|.||.:..||||..|||:::::|::.|.:.|.|| ||.|..|.|.   ||
Mouse   657 QCPPAQLHGPLDALTQLGNCAWRVNGHLLDLVLQIFRDKGCMPLGVP-PPRSEAPRPARYQLP-- 718

  Fly   875 DAEGNATSSEDRAKQFRDKLGHRRKQA-EMYSLWCDALYRLSLAQHYRDKVFWLPHNMDFRGRVY 938
                 ..|:.....:.|.:|....|.| ||:||..:||||||||||.|.:|||||||||||||.|
Mouse   719 -----PGSTPVHKSELRKELARCLKVAREMHSLRSEALYRLSLAQHLRHRVFWLPHNMDFRGRTY 778

  Fly   939 PVPPHLNHLGSDLARSMLIFDQAQPLGVDGLSWLKLHCINLTGLKKRDSVRERLLYAEEIMPDIL 1003
            |.|||.|||||||||::|.|.:.:|||..||.|||:|.||||||||.||:|.||.:|:|:|.:||
Mouse   779 PCPPHFNHLGSDLARALLEFAEGRPLGPRGLDWLKIHLINLTGLKKGDSLRMRLAFADEVMEEIL 843

  Fly  1004 DSADNPLTGRMWWSKSDEPWQTLACCMEIANVHRCPDPAAYLSRFPIHQDGSCNGLQHYAALGRD 1068
            ||||||||||.||.::||||||||||||:|:..|.||||||:|..|:||||||||||||||||||
Mouse   844 DSADNPLTGRKWWMEADEPWQTLACCMEVAHAVRSPDPAAYISHLPVHQDGSCNGLQHYAALGRD 908

  Fly  1069 EAGARSVNLAPSAIPQDVYSAVAALVEKSRKADAQNGLHVAEALAGFVRRKVIKQTVMTTVYGVT 1133
            ..||.||||.||.:|||||..||..||:.|:.||:.||.||:.|.||:.|||:||||||.|||||
Mouse   909 SVGAASVNLTPSDLPQDVYREVATQVEEFRQQDAKEGLRVAQVLEGFISRKVVKQTVMTVVYGVT 973

  Fly  1134 RYGARLQIARQLKDIDDFPKDWVWPASTYLTTKTFESLREMFTSTREIQDWFTECARLISGVCSQ 1198
            |||.||||.::|:::.|||:::||.||.||..:.|:||:|||||||.||.|.||.|.|||. ...
Mouse   974 RYGGRLQIEKRLRELSDFPQEFVWEASHYLVRQVFKSLQEMFTSTRAIQHWLTESANLISH-AGW 1037

  Fly  1199 NVEWVTPLGLPVVQPYNRQEMKH-----------------------SPRSGFKVSANM------- 1233
            .||||||||:|::|||:|:....                       |...|.:|...:
Mouse  1038 PVEWVTPLGIPIIQPYHRESKVQVLGKCPSPFPSSPLLPAKGWTHPSSNPGLQVKGGLQSITLTS 1102

  Fly  1234 PMDLYERPNILKQKNAFPPNFIHSLDSSHMMLTSLHCERQGITFVSVHDCFWTHANTVPELNRMC 1298
            .:|..::||.|||||.|||||||||||||||||:|||.|:|:.||||||||||||..:|.:|.:|
Mouse  1103 SVDESQKPNTLKQKNGFPPNFIHSLDSSHMMLTALHCYRKGLIFVSVHDCFWTHAADIPTMNEVC 1167

  Fly  1299 REQFVALHSQPILEQLSEFMRHTYSFKDSDFINDGSVEDL--SKR----QLNRILKQMPQKGDFD 1357
            |||||.||||||||.|::|::       ..|.:..|::.|  |:|    :|...|:.:|:.|.||
Mouse  1168 REQFVRLHSQPILEDLAKFLK-------KRFCSVSSIKSLKSSERALVTKLQETLQSLPKTGTFD 1225

  Fly  1358 LRNVLDSVYFFS 1369
            |..|:.|.||||
Mouse  1226 LGQVIRSTYFFS 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolrMT	NP_608565.1	PPR repeat	314..342	CDD:276811	3/27 (11%)
		PPR repeat	355..384	CDD:276811	10/28 (36%)
		PPR_2	358..402	CDD:463778	17/43 (40%)
		PHA00452	507..1369	CDD:222797	417/910 (46%)
		RNA_pol	962..1369	CDD:460006	248/442 (56%)
Polrmt	XP_030100878.1	PPR repeat	233..262	CDD:276811	10/28 (36%)
		PPR repeat	268..298	CDD:276811	8/32 (25%)
		RPOL_N	374..675	CDD:464270	100/327 (31%)
		RNA_pol	802..1237	CDD:460006	248/442 (56%)