DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtRNApol and rpom-1

DIOPT Version :9

Sequence 1:	NP_001259853.1	Gene:	mtRNApol / 33285	FlyBaseID:	FBgn0261938	Length:	1369	Species:	Drosophila melanogaster
Sequence 2:	NP_001122532.1	Gene:	rpom-1 / 173317	WormBaseID:	WBGene00013680	Length:	1156	Species:	Caenorhabditis elegans

Alignment Length:	1293	Identity:	417/1293 - (32%)
Similarity:	611/1293 - (47%)	Gaps:	270/1293 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 EYTKQVIANPEEVQNILKSFQNFRDIIESMENDQHEADFGLSTTKVHPEEHEMLDPFEAIEPYIS 262
            ::.:.|.:.|..:..|.|:     .:...::..:.|.|:.....|:...||:
Worm    13 QWCRLVSSTPAAISTISKN-----AVKNGVKKKEEEKDWKSELLKILEVEHK------------- 59

  Fly   263 PLDKSKRSVTTVAVPN---ASAVTTKSKKRFKSKVHVNEEQERLAKQRALHINLNTYLNVCVSAN 324
               :.||.:....|..   |..|....:...:|.|.:.|.|.|....:.:       :.:|:.
Worm    60 ---QKKRGIWRQRVKQIALADIVRFTLRDDLQSLVRLTENQLRSRATQEI-------VPICLL-- 112

  Fly   325 MLNRALSTIIAYRGKVRKSSLPHMSEGLI------------TIDLYNILL----HGYAGKGSFDR 373
            :||:....|:.....:..:|...:..|:.            |..|..|||    ..:..:..||
Worm   113 VLNKKFEKILRKTDSIESTSSLSLFIGISELWKSIKRSENNTTSLVAILLLSNIRKWKDQRKFD- 176

  Fly   374 AQEVFKLIEEDGLSFNE-QTYAAIFECLGRLEPDEENHQYI-SEYVSKAEKEGFSLNQIMDRSKF 436
             .:.:|.||:   .|:| |...|:.....|:. |::...:| :|.:...:||
Worm   177 -AKSWKTIED---LFDEMQRKMALLAQNVRIS-DQQLEVFIGTEDLKSIQKE------------- 223

  Fly   437 VADQRDIALDAIRRLRPDFKPVYVP------PQLGY--DNELLDHLNEHVIPVGAKKEPGKADYA 493
                    :|.||:.       |:|      .::.|  |.||:..|..:......:..|.:.|
Worm   224 --------VDQIRKF-------YIPLGRNLLEKMRYLEDLELVAPLQGNCSSEEYRMNPFQVD-- 271

  Fly   494 IMNSKRGYTAAQLEQLAREQLKIELDGSITIK-SIEKSKEFANSEKCRELLKELEDTWRKQISAA 557
                  |...:..::|..:.|.:|....|.:| ::.::.|..|:....:|:.|.:  |:::|
Worm   272 ------GIEKSNYKRLFEDHLNVESSMWIHVKNTVGEAAENNNAVSGEDLISEWD--WKRRI--- 325

  Fly   558 IVRDLNTLRAQVRFKPHGFMNYYTYL----KTLDASHFADILIKELYKLAEGSETFSPTVGQ--- 615
              ||  .||.......|..::....|    |.::..||:     .|...::|......:..|
Worm   326 --RD--GLRKIDPNDTHPIVSTCLELLPREKLVETLHFS-----ALSACSQGQNLIGASQFQFDV 381

  Fly   616 ---LYKELGQKVQQRYQIEQKKHNGTLEKIGEIYSSYCELWG-SGMSQDNTRQAW-------QRL 669
               :.||||...::....::.      |....::::|.:.:. |.:|:.||.:.|       |.:
Worm   382 LEPILKELGNAFKKEMGYDEN------EIWKRVFATYIDYFSDSEISRQNTHREWWNKSCKTQGI 440

  Fly   670 VYE-QRESGPSMDLLEVPWPSNVLTGVGRFLYNILMRDIKIDAHIMRQKSK-SKAAAQPQNLLPA 732
            ..: |.|.| :||       |.....|...|.|::     .|:.:...:|| ||...|
Worm   441 TSDFQFEMG-NMD-------SETRNEVCNVLINVI-----FDSCLFPYESKDSKVTWQ------- 485

  Fly   733 FYTLFRNQGRFVKEEVKPHP----VLSR----------LFRASRQQTLTFDSNLVPMLCPPQPWS 783
              ..|..:...::||.|...    .|||          ||..:....:.|.::.:||:.||:||.
Worm   486 --RAFSYRSISIEEESKVSTDGRLSLSRMLSINSKLMGLFDKNPFNFIVFSTSNLPMIVPPRPWI 548

  Fly   784 TPHNGG--YLLNKTELIR--LPHQAIQQWDRIMA--SNPQHLYPALDSLNQLASVPWRVNTQLLD 842
            ....||  |..::.|:||  :..:|::..:.:.|  ::.....|..|:||||.|.||.:|..:||
Worm   549 DRGTGGPLYTTSQHEIIRKMMEFRAVRLNEEMRARITSQAQARPVFDALNQLGSTPWVINEPMLD 613

  Fly   843 VIIKVFQNGGD-------VKLDVPQPPSSLPPLPTLPAKDAE-GNATSSED-RAKQFRDKLGHRR 898
            |:..||...|:       .||::|....:.    .:|....| |.....|| ..::||   .:.:
Worm   614 VLKDVFGRSGNSESRGLLEKLEIPMRHDTF----DIPDFGREFGIGIKKEDVDVEKFR---SYAK 671

  Fly   899 KQAEMY-------SLWCDALYRLSLAQHYRDKVFWLPHNMDFRGRVYPVPPHLNHLGSDLARSML 956
            |:||..       ||||...||:.||.|:|.:..:.||||||||||||:.|:|:|:|.|:.|.:|
Worm   672 KKAEAIKMRNESNSLWCWMQYRVVLADHFRGQTLFFPHNMDFRGRVYPLSPYLSHMGDDVNRCIL 736

  Fly   957 IFDQAQPLGVDGLSWLKLHCINLTGLKKRDSVRERLLYAEEIMPDILDSADNPLTGRMWWSKSDE 1021
            .|.::|.||..|..|||||||||||..||.||.:|::.||.::|.:||||.:||.|:.||..|||
Worm   737 KFAKSQKLGEKGFDWLKLHCINLTGTMKRSSVADRMVEAERLIPLMLDSARDPLNGQKWWMSSDE 801

  Fly  1022 PWQTLACCMEIANVHRC-PDPAAYLSRFPIHQDGSCNGLQHYAALGRDEAGARSVNLAPSAIPQD 1085
            ||||||.|:||.|..|. .|.|.:.|:.||||||||||||||||||||..|...|||..|..|.|
Worm   802 PWQTLAACVEIENATRYGSDVALFPSQLPIHQDGSCNGLQHYAALGRDNEGGVQVNLTQSDTPND 866

  Fly  1086 VYSAVAALVEKSRKADAQ-NG------LHVAEALAGFVRRKVIKQTVMTTVYGVTRYGARLQIAR 1143
            |||.||..||:.|:.|.| ||      ..:.|||...|.||||||||||||||||.|||.|||.|
Worm   867 VYSDVAQRVEQKRQQDEQSNGEDCDVARKLREALPQNVPRKVIKQTVMTTVYGVTMYGAVLQIKR 931

  Fly  1144 QLKDIDDFPKDWVWPA-----------------STYLTTKTFESLREMFTSTREIQDWFTECARL 1191
            |||.:|...:|....|                 :.||..|||.||.:.|||:..::|||    ||
Worm   932 QLKAMDIPGEDAAIFARYLARKTFASLNDAAIFARYLARKTFASLNDAFTSSMALKDWF----RL 992

  Fly  1192 I---SGVCSQNVEWVTPLGLPVVQPYNRQEMKHSPRSGFKVSANMPMDLYERPNILKQKNAFPPN 1253
            |   |....:.|||:|||||||||||    .|...|.|..:.|.:||         ||.:|||||
Worm   993 IAKGSSDLMKTVEWITPLGLPVVQPY----CKLVERKGKLILAPVPM---------KQVDAFPPN 1044

  Fly  1254 FIHSLDSSHMMLTSLHCERQGITFVSVHDCFWTHANTVPELNRMCREQFVALHSQPILEQLSEFM 1318
            |:|||||:|||||||:|.::||||.:||||||||||:|.::|.:||:|||:||||||:||.||:.
Worm  1045 FVHSLDSTHMMLTSLNCAQRGITFAAVHDCFWTHANSVDQMNEICRQQFVSLHSQPIVEQCSEWF 1109

  Fly  1319 RHTY-------SFKDSDFINDGSVEDLSKRQLNRILKQMPQKGDFDLRNVLDSVYFFS 1369
            :.||       ...:.||           ::.:.|.....:.||.|:..|.|||||||
Worm  1110 KKTYLTPKMAKILPEKDF-----------QKYSEIFTANIEHGDLDIEKVKDSVYFFS 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtRNApol	NP_001259853.1	RPO41	286..1369	CDD:227439	401/1200 (33%)
		PPR repeat	314..342	CDD:276811	4/27 (15%)
		PPR repeat	355..384	CDD:276811	9/32 (28%)
		PPR	358..386	CDD:279828	8/31 (26%)
		RPOL_N	513..829	CDD:291372	77/356 (22%)
		RNA_pol	962..1368	CDD:279308	223/440 (51%)
rpom-1	NP_001122532.1	RPOL_N	<512..601	CDD:291372	22/88 (25%)
rpom-1	NP_001122532.1	RNA_pol	742..1155	CDD:279308	223/440 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166357
Domainoid	1	1.000	391	1.000	Domainoid score	I404
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D135329at2759
OrthoFinder	1	1.000	-	-		FOG0003398
OrthoInspector	1	1.000	-	-		oto19840
orthoMCL	1	0.900	-	-		OOG6_101824
Panther	1	1.100	-	-	LDO	PTHR10102
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1209
SonicParanoid	1	1.000	-	-		X2294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.880