Protein Alignment PolrMT and nedd4

DIOPT Version :10

• Sequence 1: NP_608565.1
• Gene: PolrMT / 33285
• FlyBaseID: FBgn0261938
• Length: 1369
• Species: Drosophila melanogaster
• Sequence 2: XP_031755033.1
• Gene: nedd4 / 100496333
• XenbaseID: XB-GENE-478443
• Length: 1283
• Species: Xenopus tropicalis
• Alignment Length: 965
• Identity: 173/965 - (17%)
• Similarity: 299/965 - (30%)
• Gaps: 313/965 - (32%)

  Fly   192 LFFGKDEYTKQVIANPEEVQNILKSFQNFRDIIESMENDQHEADFGLSTTKVHPEEHEMLDPF-- 254
            |||           ||||.....||     .:.|.:..:..:..|.|.    |.|:.|:..|.
 Frog   210 LFF-----------NPEENCEFFKS-----KLEEPLPINNCKFHFDLD----HSEKEEVRIPARK 254

  Fly   255 -------EAIEPYISPLDKSKRSVTTVAVPNASAVTTKSKKRFKSKVHVNEEQERLAKQRALHIN 312
                   ......|.|.|....|.|::..|.:......|.:...|.....:::|:.|.:.:|...
 Frog   255 KTRIPLRRCSSLVIFPSDTPPTSPTSLVPPLSRGCYQTSYQLMLSSNDFTQKEEQAASKGSLSTA 319

  Fly   313 LNTYLNVCVSANMLNRALSTIIAYRGKVRKSS---LPHMSEGLITIDLYNILLHGYAGKGSFDRA 374
            :|   .|.:|.|..|         .|:||...   |....:||..|               .:..
 Frog   320 VN---GVRLSKNTCN---------VGEVRDVKPLYLNDKDDGLPNI---------------CNSV 357

  Fly   375 QEVFKLIEEDGLSFNEQTYAAIFECLGRLEPDEENHQYISEYVSKAEKEGF------SLNQIMDR 433
            .|..||.|:.....::..:..:........|   :::.:...:.::.::|:      .|..:..|
 Frog   358 AEHSKLHEDKPQLNSDARHCRLVRSTSAYSP---SNKTVECQMGRSSEQGYKNIHKCQLTHVFQR 419

  Fly   434 SKFVAD---QRDIALDAIRRLRPDFKPVYVPPQLGYDNE-LLDHLNEHVIPVGAKKEPGKADYAI 494
            |  |::   |:..:..:::...|.....|:..|....|| .:....:..:.....:.|||....:
 Frog   420 S--VSEGPPQKRSSASSLKCRHPKSGSSYLHIQFAPGNESRISSYKKQSLRSPTTELPGKPSVKL 482

  Fly   495 MNSK---RGYTAAQLEQLAREQLKIE------------------LDGSITIKSIEKSKEFANSEK 538
            :.::   .|.....|.||..|..::|                  :.|::.:|.....|...:.::
 Frog   483 LKTRDDFLGQVDVPLHQLPTENPRLERPYTFKDFILHPRSHKSRVKGNLRLKMTYLPKNNGSEDE 547

  Fly   539 CRELLKELEDTWRKQISAAIVRDLNTLRAQVRFKPHGFMNYYTYLKTLDASHFADILIKELYKLA 603
            ..|..:|:|..|       ::.|......|.:.:                        :||..|.
 Frog   548 NAEQAEEMEPGW-------VILDQPDTSCQPQQE------------------------QELSPLP 581

  Fly   604 EGSETFSPTVGQLYKELGQKVQQRYQIEQKKHNGTLEKIGEIYSSYCELWGSGMSQDNTRQ---- 664
            .|.|.....:|:.|     .|..:|:..|                    |.....||:|..
 Frog   582 PGWEERQDILGRTY-----YVSHQYRRTQ--------------------WQRPTIQDDTAANESR 621

  Fly   665 ------------AWQRLVYEQRESGPSMDLLEVPWPSNVLTGVGRFLYNILMRDIKIDAHIMRQK 717
                        ..:|.:.|:.||..|.:..|      ::|.....:|:         ....:|.
 Frog   622 NVQLEEQHHHAFTTRRQISEETESRDSPESWE------IITEDETTIYS---------NQNAQQG 671

  Fly   718 SKSKAAAQPQNLLPAFYTLFRNQGRFVKEEVKPHPVLSRLFRASRQQTLTFDSN----------- 771
            |...:.||.|                :.||:.....:|.....|||.:....||
 Frog   672 SAPTSDAQAQ----------------ITEELSIRLNISGNMPNSRQSSSNVHSNRRESLQSYTSE 720

  Fly   772 ---LVPMLCP-----PQPWSTPHNGGYLLNKTELIRLPHQA-IQQWDR--IMASNPQHLYPALDS 825
               .||:|.|     |..|...|:     :|.....:.|.: ...|::  ..|..|...:    .
 Frog   721 ELPTVPVLLPTSSGLPPGWEEKHD-----DKGRSYYIDHNSRTTTWEKPSSQAQGPTETF----Q 776

  Fly   826 LNQLASVP--------WRVNTQLLDVIIKVFQNGGDV-------------------------KLD 857
            .:.:.:||        .|.:||||:...:....|.:|                         |:.
 Frog   777 TSSVQNVPVIFQPQTATRESTQLLETEQRFLPKGWEVRHAPTGRPFYINHVTKTTTWEDPRLKIP 841

  Fly   858 V---PQPPSSLPPLPTLPAKDAEGNATSSEDRAKQFRDKLGHRRKQAEMYSLWCDALYRLSLAQH 919
            |   |:||..|..|..||....|  .|.::.|...    :.|..||.:    |.|.  ||..|..
 Frog   842 VQLRPKPPIDLSDLGPLPPGWEE--RTHNDGRVFY----IDHNTKQTQ----WEDP--RLQTAAI 894

  Fly   920 YRDKVFWLPHNMDFRGRVY-----------PVPPHLNHLGSDLARSMLIFDQ-------AQPLGV 966
            ....|   |::.|:: |.|           .:|   |.....|.|:.::.|.       .:|..:
 Frog   895 TGPAV---PYSRDYK-RKYEYFRKKLKKQIDIP---NRFEMKLRRTAILEDSYRRIIAVKRPEFL 952

  Fly   967 DGLSWLKLHCINLTGLKKRDSVRE-RLLYAEEIMPDILDSADNPLTGRMWWSKSD 1020
            ....|::..  |..||......|| ..|.::|:.        ||..|...:|.:|
 Frog   953 KARLWIEFD--NEKGLDYGGVAREWFFLISKEMF--------NPYYGLFEYSATD 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolrMT	NP_608565.1	PPR repeat	314..342	CDD:276811	7/27 (26%)
		PPR repeat	355..384	CDD:276811	5/28 (18%)
		PPR_2	358..402	CDD:463778	4/43 (9%)
		PHA00452	507..1369	CDD:222797	113/625 (18%)
		RNA_pol	962..1369	CDD:460006	14/60 (23%)
nedd4	XP_031755033.1	C2	<485..538	CDD:472691	8/52 (15%)
		WW	579..611	CDD:197736	9/56 (16%)
		WW	735..764	CDD:459800	6/33 (18%)
		WW	807..836	CDD:459800	2/28 (7%)
		WW	857..889	CDD:197736	10/43 (23%)
		HECTc	950..1279	CDD:214523	13/58 (22%)