DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4629 and MELK

DIOPT Version :9

Sequence 1:NP_608564.3 Gene:CG4629 / 33284 FlyBaseID:FBgn0031299 Length:570 Species:Drosophila melanogaster
Sequence 2:NP_055606.1 Gene:MELK / 9833 HGNCID:16870 Length:651 Species:Homo sapiens


Alignment Length:666 Identity:160/666 - (24%)
Similarity:266/666 - (39%) Gaps:204/666 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 YRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVVDLDRAGLDAKALRMLSSEIATLECVHHPNILRL 130
            |.....||.|.|:|||||.|.||.:.||||::|.:..|.|   |..:.:||..|:.:.|.:|.:|
Human    11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD---LPRIKTEIEALKNLRHQHICQL 72

  Fly   131 FEVVETLGRVYLVTEWIRGGELYNHITQGGPLREIHAAPLLKQLLLAVKHMHSLGYVHRDIKAEN 195
            :.|:||..::::|.|:..||||:::|.....|.|.....:.:|::.||.::||.||.|||:|.||
Human    73 YHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPEN 137

  Fly   196 VLLLSEDRLKLADFGFSTQLINGANQKLDTFCGSPPYAAPELFSDDHYIGAPVDVWALGILLYFM 260
            :|.....:|||.|||...:.....:..|.|.|||..||||||.....|:|:..|||::|||||.:
Human   138 LLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVL 202

  Fly   261 VVGNMPFRAPTIPGLKAAILKGDYLLPGQLSLPCIRLIQRIL----------------------- 302
            :.|.:||....:..|...|::|.|.:|..||...|.|:|::|                       
Human   203 MCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDY 267

  Fly   303 ------------------------IHIPAQRPTIDDMLN-------------------------- 317
                                    :|....|.|::|:::                          
Human   268 NYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRL 332

  Fly   318 --SQFVTCPKLSA----DLM--QWEINQHTKPVKRSI---------------------------F 347
              |.| :|.:.||    |:.  .|.:...|...|..:                           :
Human   333 RLSSF-SCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKY 396

  Fly   348 W-----VRSKS----------HRLR--------KSASLRDRYAEVVK-KPAISMNTRQQDEMFVQ 388
            |     |.|||          ::|:        |||...:.|....: |..::.|..:::.:...
Human   397 WTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTP 461

  Fly   389 N-FLQPIEMGHELL------VPVSS----------------------QLKEPQSTEQAKRPTRRY 424
            | :..|.:..::.|      :||:|                      .|.:....|..||...:.
Human   462 NRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKV 526

  Fly   425 MFCGSLKK---KVTPMETEPEKQLANGGQSIGSAKINPWNVEVAEDCPLFKNYDAETGSCV---- 482
            .  |||::   ||..:.|..:::        |||:..|..:::        :|:..|...|    
Human   527 F--GSLERGLDKVITVLTRSKRK--------GSARDGPRRLKL--------HYNVTTTRLVNPDQ 573

  Fly   483 -------MLPTNTEDLSQLG-ALEFEARQILAELGLTSEMLINARQSGPRSDIIGAYRIVVNRLQ 539
                   :||....|..|.| .|:.:.:....::.:..|:.:...|   :.|::|..|   .||:
Human   574 LLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQ---KPDVVGIRR---QRLK 632

  Fly   540 KQSWLARKHVEMALHS 555
            ..:|:.::.||..|.|
Human   633 GDAWVYKRLVEDILSS 648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4629NP_608564.3 STKc_NIM1 63..321 CDD:270977 99/329 (30%)
S_TKc 66..321 CDD:214567 99/329 (30%)
MELKNP_055606.1 STKc_MELK 7..263 CDD:270980 94/254 (37%)
S_TKc 11..263 CDD:214567 94/254 (37%)
UBA_MELK 281..332 CDD:270526 4/50 (8%)
UBA-like 282..321 4/38 (11%)
Autoinhibitory region 326..651 62/348 (18%)
MELK_C 555..649 CDD:213383 21/108 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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