DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4629 and KIN1

DIOPT Version :9

Sequence 1:	NP_608564.3	Gene:	CG4629 / 33284	FlyBaseID:	FBgn0031299	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_010407.1	Gene:	KIN1 / 851700	SGDID:	S000002529	Length:	1064	Species:	Saccharomyces cerevisiae

Alignment Length:	492	Identity:	126/492 - (25%)
Similarity:	218/492 - (44%)	Gaps:	93/492 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PPPPTPPYQRLTKALQCDPRCGHEVTIGRRIGLYRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVV 97
            |.|.|....|::.: |..|:..|.    :.:|.:.|...:|.|:..|||||.|:.|.:..|:|:|
Yeast    92 PKPNTTSQSRVSSS-QGMPKQFHR----KSLGDWEFVETVGAGSMGKVKLAKHRYTNEVCAVKIV 151

  Fly    98 D-LDRAGLDAKAL--------------RMLSSEI---------ATL-ECVHHPNILRLFEVVETL 137
            : ..:|.|..:.:              :.|..||         |:| :.::||:|.||||:....
Yeast   152 NRATKAFLHKEQMLPPPKNEQDVLERQKKLEKEISRDKRTIREASLGQILYHPHICRLFEMCTLS 216

  Fly   138 GRVYLVTEWIRGGELYNHITQGGPLREIHAAPLLKQLLLAVKHMHSLGYVHRDIKAENVLLLSED 202
            ...|::.|::.||:|.::|.|.|.:||..|....:.:..|:.::|:...||||:|.||:::....
Yeast   217 NHFYMLFEYVSGGQLLDYIIQHGSIREHQARKFARGIASALIYLHANNIVHRDLKIENIMISDSS 281

  Fly   203 RLKLADFGFSTQLINGANQKLDTFCGSPPYAAPELFSDDHYIGAPVDVWALGILLYFMVVGNMPF 267
            .:|:.|||.|.  |..:.::|.|||||..:|||||...:.|.|..||||:.|::|:.:|.|.:||
Yeast   282 EIKIIDFGLSN--IYDSRKQLHTFCGSLYFAAPELLKANPYTGPEVDVWSFGVVLFVLVCGKVPF 344

  Fly   268 RAPTIPGLKAAILKGDYLLPGQLSLPCIRLIQRILIHIPAQRPTIDDMLNSQFVT---------- 322
            .......|...|.:|....|..||:..|.|:.::|:..|.:|.|:..::...::.
Yeast   345 DDENSSVLHEKIKQGKVEYPQHLSIEVISLLSKMLVVDPKRRATLKQVVEHHWMVRGFNGPPPSY 409

  Fly   323 CPK---LSADLMQWEINQHTKPVKRSIFWVRSKSHRLR---KSASLRDRYAEVVKKP-------- 373
            .||   |:.:::  :||            |..:.:||.   .....|.....::..|
Yeast   410 LPKRVPLTIEML--DIN------------VLKEMYRLEFIDDVEETRSVLVSIITDPTYVLLSRQ 460

  Fly   374 ----AISMNTRQQDE----MFVQNFLQPIEMGH----------ELLVPVSSQLKEPQSTEQAKRP 420
                |..||....|.    ...::|..|....|          |:|....::::..|..:..:..
Yeast   461 YWTLAAKMNAESSDNGNAPNITESFEDPTRAYHPMISIYYLTSEMLDRKHAKIRNQQQRQSHENI 525

  Fly   421 TRRYMFCGSLKKK-----VTPMETEPEKQLANGGQSI 452
            .:......|:|::     .|.|::|||..||....|:
Yeast   526 EKLSEIPESVKQRDVEVNTTAMKSEPEATLATKDTSV 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	89/282 (32%)
CG4629	NP_608564.3	S_TKc	66..321	CDD:214567	88/279 (32%)
KIN1	NP_010407.1	STKc_Kin1_2	118..398	CDD:270979	89/281 (32%)
KIN1	NP_010407.1	MARK_C_like	890..1062	CDD:213377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345327
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930