DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4629 and KIN2

DIOPT Version :9

Sequence 1:	NP_608564.3	Gene:	CG4629 / 33284	FlyBaseID:	FBgn0031299	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_013197.1	Gene:	KIN2 / 850785	SGDID:	S000004086	Length:	1147	Species:	Saccharomyces cerevisiae

Alignment Length:	417	Identity:	115/417 - (27%)
Similarity:	194/417 - (46%)	Gaps:	68/417 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 RRIGLYRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVVD-LDRAGL-----------DAKAL---R 110
            |.:|.:.|...:|.|:..||||..|:.|::...||:|: ..:|.|           :::.|   :
Yeast    94 RSLGDWEFLETVGAGSMGKVKLVKHRQTKEICVIKIVNRASKAYLHKQHSLPSPKNESEILERQK 158

  Fly   111 MLSSEIA----TL------ECVHHPNILRLFEVVETLGRVYLVTEWIRGGELYNHITQGGPLREI 165
            .|..|||    |:      :.::||:|.||||:.......|::.|::.||:|.::|.|.|.|:|.
Yeast   159 RLEKEIARDKRTVREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEH 223

  Fly   166 HAAPLLKQLLLAVKHMHSLGYVHRDIKAENVLLLSEDRLKLADFGFSTQLINGANQKLDTFCGSP 230
            ||....:.:..|::::|:...||||:|.||:::.|...:|:.|||.|.  |....::|.|||||.
Yeast   224 HARKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSN--IFDYRKQLHTFCGSL 286

  Fly   231 PYAAPELFSDDHYIGAPVDVWALGILLYFMVVGNMPFRAPTIPGLKAAILKGDYLLPGQLSLPCI 295
            .:|||||.....|.|..||:|:.||:||.:|.|.:||.......|...|.||....|..||:..|
Yeast   287 YFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKVPFDDENSSILHEKIKKGKVDYPSHLSIEVI 351

  Fly   296 RLIQRILI----------------------------HIPAQRPTIDDMLNSQFVTCPKLSADLMQ 332
            .|:.|:::                            ::|.:.|...:|::||.:      .::.:
Yeast   352 SLLTRMIVVDPLRRATLKNVVEHPWMNRGYDFKAPSYVPNRVPLTPEMIDSQVL------KEMYR 410

  Fly   333 WEINQHTKPVKRSIFWVRSKSHRLRKSASLRDRYAEVVKKPAISMNTRQQDEMFVQNFLQPIEMG 397
            .|.....:..:||:..:.::...::.|....|:.:. .|..:.|:|....:....|..:|    .
Yeast   411 LEFIDDIEDTRRSLIRLVTEKEYIQLSQEYWDKLSN-AKGLSSSLNNNYLNSTAQQTLIQ----N 470

  Fly   398 HELLVPVSSQLKEPQSTEQAKRPTRRY 424
            |....|..|...||.|  ..:.||..|
Yeast   471 HITSNPSQSGYNEPDS--NFEDPTLAY 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	95/310 (31%)
CG4629	NP_608564.3	S_TKc	66..321	CDD:214567	94/307 (31%)
KIN2	NP_013197.1	STKc_Kin1_2	97..377	CDD:270979	90/281 (32%)
KIN2	NP_013197.1	KA1	1104..1147	CDD:396635
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345326
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930