DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4629 and BRSK1

DIOPT Version :9

Sequence 1:	NP_608564.3	Gene:	CG4629 / 33284	FlyBaseID:	FBgn0031299	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_115806.1	Gene:	BRSK1 / 84446	HGNCID:	18994	Length:	778	Species:	Homo sapiens

Alignment Length:	316	Identity:	94/316 - (29%)
Similarity:	157/316 - (49%)	Gaps:	42/316 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SATVKVTSAATP----PHPPPLTTTTTPLTICQPPPPTPPYQRLTKALQCDPRCGHEVTIGRRIG 64
            |:..|.....:|    |||.|            .||....|                      :|
Human     2 SSGAKEGGGGSPAYHLPHPHP------------HPPQHAQY----------------------VG 32

  Fly    65 LYRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVVDLDRAGLDAKALRMLSSEIATLECVHHPNILR 129
            .||....:|:|....|||.||.:|..|||||:|  :|..|....|..:..|||.|:.:.||::|:
Human    33 PYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIV--NREKLSESVLMKVEREIAILKLIEHPHVLK 95

  Fly   130 LFEVVETLGRVYLVTEWIRGGELYNHITQGGPLREIHAAPLLKQLLLAVKHMHSLGYVHRDIKAE 194
            |.:|.|....:|||.|.:.||||::::.:.|.|....|....:|::.|:...||....|||:|.|
Human    96 LHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPE 160

  Fly   195 NVLLLSEDRLKLADFGFSTQLINGANQKLDTFCGSPPYAAPELFSDDHYIGAPVDVWALGILLYF 259
            |:||..::.:::||||.::  :...:..|:|.||||.||.||:...:.|.|...|:|:.|::|:.
Human   161 NLLLDEKNNIRIADFGMAS--LQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFA 223

  Fly   260 MVVGNMPFRAPTIPGLKAAILKGDYLLPGQLSLPCIRLIQRILIHIPAQRPTIDDM 315
            ::||.:||....:..|...:.:|.:.:|..:...|..|::.::...|.:|.:::.:
Human   224 LLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQI 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	84/253 (33%)
CG4629	NP_608564.3	S_TKc	66..321	CDD:214567	83/250 (33%)
BRSK1	NP_115806.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		9/38 (24%)
		STKc_BRSK1_2	32..285	CDD:270983	84/252 (33%)
		UBA_BRSK	314..367	CDD:270525
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..548
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	719..778
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910