DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4629 and Sik3

DIOPT Version :9

Sequence 1:	NP_608564.3	Gene:	CG4629 / 33284	FlyBaseID:	FBgn0031299	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_081774.3	Gene:	Sik3 / 70661	MGIID:	2446296	Length:	1369	Species:	Mus musculus

Alignment Length:	585	Identity:	166/585 - (28%)
Similarity:	270/585 - (46%)	Gaps:	117/585 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AATPPHPPPLTTTTTPLTICQPPPPTPPYQRLTKALQCDPRCGHEVTIGRRIGLYRFCGDIGRGN 76
            ||.||..|   ....|..:  |..||.|..|.:.|              .|||.|.....||:||
Mouse    31 AAGPPAAP---AAVPPAAV--PARPTAPASRGSMA--------------ARIGYYEIDRTIGKGN 76

  Fly    77 FSKVKLAVHQLTRDKVAIKVVDLDRAGLDAKALRMLSSEIATLECVHHPNILRLFEVVETLGRVY 141
            |:.||.|.|.:|:.|||||::  |::.||.:.|:.:..|:..::.:.||:|:||::|:||...:|
Mouse    77 FAVVKRATHLVTKAKVAIKII--DKSQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIY 139

  Fly   142 LVTEWIRGGELYNHITQGGPLREIHAAPLLKQLLLAVKHMHSLGYVHRDIKAENVLLLSEDRLKL 206
            ||||:..|||:::|:...|.:.|..|....||::.||...|....||||:||||:||.:...:|:
Mouse   140 LVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 204

  Fly   207 ADFGFSTQLINGANQKLDTFCGSPPYAAPELFSDDHYIGAPVDVWALGILLYFMVVGNMPFRAPT 271
            ||||||.....|  |.|.|:||||||||||||....|.|..||:|:||::||.:|.|.:||...|
Mouse   205 ADFGFSNLFTPG--QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST 267

  Fly   272 IPGLKAAILKGDYLLPGQLSLPCIRLIQRILIHIPAQRPTIDDMLNSQFV-------TCPKLSAD 329
            :..|:|.:|.|.:.:|..:|..|..||:.:|:..|.:|.:::.:...:::       ...:|.|:
Mouse   268 LQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICRHKWMKLGDADPNFDRLIAE 332

  Fly   330 LMQWEINQHTKPVKRSIFWVRSKS--HRLRKSASLR----DRYAEVVK------------KPAIS 376
            ..|.:..:.:.|:...:.......  .:.|...|||    |.|:.:..            :|...
Mouse   333 CQQLKEERQSDPLNDDVLLAMEDMGLDKERTLQSLRSDAYDHYSAIYSLLCDRHKKHKTLRPGAL 397

  Fly   377 MNTRQQDEMFVQNFLQPIEMGHE-------LLVP------VSSQLKEPQ-----STEQAKRPTR- 422
            .:..|     ...|..|:.:..|       |.||      ..:|:.||.     .:::.:.|:.
Mouse   398 PSMPQ-----AMTFQAPVNLQAEQTGTAMNLSVPQVQLINPENQIIEPDGAVNLDSDEGEEPSPE 457

  Fly   423 ---RYMFCGSLKKKVTPMETEPEKQLANGGQSI--GSAKINPWN--VEVAEDCPLFKNYDAETGS 480
               ||:   |:::....: .:|..::....|.:  |...:||..  ::||.:.....|
Mouse   458 ALVRYL---SMRRHTVGV-ADPRTEVMEDLQKLLPGFPGVNPQGPFLQVAPNMNFTHN------- 511

  Fly   481 CVMLPTNTEDLSQLGALEFEARQIL----------------------AELGLTSEMLINARQSGP 523
              :||  .:.|...|.||::.:.:|                      |.:.|.::.|:. |..||
Mouse   512 --LLP--MQSLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLK-RPRGP 571

Fly 524 523
Mouse 572 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	107/257 (42%)
CG4629	NP_608564.3	S_TKc	66..321	CDD:214567	105/254 (41%)
Sik3	NP_081774.3	STKc_SIK	65..317	CDD:270973	105/255 (41%)
		S_TKc	66..317	CDD:214567	105/254 (41%)
		UBA_SIK3	346..390	CDD:270593	6/43 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910