Protein Alignment CG4629 and Sik3

DIOPT Version :10

• Sequence 1: NP_608564.3
• Gene: CG4629 / 33284
• FlyBaseID: FBgn0031299
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: NP_001258145.2
• Gene: Sik3 / 684112
• RGDID: 1593938
• Length: 1369
• Species: Rattus norvegicus
• Alignment Length: 582
• Identity: 165/582 - (28%)
• Similarity: 268/582 - (46%)
• Gaps: 113/582 - (19%)

  Fly    15 PPHPPPLTTTTTPLTICQPPPPTPPYQRLTKALQCDPRCGHEVTIGRRIGLYRFCGDIGRGNFSK 79
            |...||......|...| ||.||.|..|.:.|              .|||.|.....||:|||:.
  Rat    30 PAAGPPAAPAAVPPAAC-PPRPTAPASRGSMA--------------ARIGYYEIDRTIGKGNFAV 79

  Fly    80 VKLAVHQLTRDKVAIKVVDLDRAGLDAKALRMLSSEIATLECVHHPNILRLFEVVETLGRVYLVT 144
            ||.|.|.:|:.|||||::  |:..||.:.|:.:..|:..::.:.||:|:||::|:||...:||||
  Rat    80 VKRATHLVTKAKVAIKII--DKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVT 142

  Fly   145 EWIRGGELYNHITQGGPLREIHAAPLLKQLLLAVKHMHSLGYVHRDIKAENVLLLSEDRLKLADF 209
            |:..|||:::|:...|.:.|..|....||::.||...|....||||:||||:||.:...:|:|||
  Rat   143 EYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 207

  Fly   210 GFSTQLINGANQKLDTFCGSPPYAAPELFSDDHYIGAPVDVWALGILLYFMVVGNMPFRAPTIPG 274
            |||.....|  |.|.|:||||||||||||....|.|..||:|:||::||.:|.|.:||...|:..
  Rat   208 GFSNLFTPG--QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN 270

  Fly   275 LKAAILKGDYLLPGQLSLPCIRLIQRILIHIPAQRPTIDDMLNSQFV-------TCPKLSADLMQ 332
            |:|.:|.|.:.:|..:|..|..||:.:|:..|.:|.:::.:...:::       ...:|.|:..|
  Rat   271 LRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICRHRWMKLGDADPNFERLIAECQQ 335

  Fly   333 WEINQHTKPVKRSIFWVRSKS--HRLRKSASLR----DRYAEVVK------------KPAISMNT 379
            .:..:..:|:...:.......  .:.|...|||    |.|:.:..            :|....:|
  Rat   336 LKEERQAEPLNDEVLLAMEDMGLDKERTLQSLRSDAYDHYSAIYSLLCDRHKKNKTLRPGALPST 400

  Fly   380 RQQDEMFVQNFLQPIEMGHE-------------LLVPVSSQLKEPQ-----STEQAKRPTR---- 422
            .|     ...|..|:.:..|             .|:...:|:.||.     .:::.:.|:.
  Rat   401 PQ-----AMTFQAPVNIQAEQTGTAMNISVPQVQLINPENQIIEPDGAVNLDSDEGEEPSPEALV 460

  Fly   423 RYMFCGSLKKKVTPMETEPEKQLANGGQSI--GSAKINPWN--VEVAEDCPLFKNYDAETGSCVM 483
            ||:   |:::....: .:|..::.:..|.:  |....||..  ::||.:.....|         :
  Rat   461 RYL---SMRRHTVGV-ADPRTEVMDEMQKLLPGFPGANPQTPFLQVAPNMNFMHN---------L 512

  Fly   484 LPTNTEDLSQLGALEFEARQIL----------------------AELGLTSEMLINARQSGP 523
            ||  .:.|...|.||::.:.:|                      |.:.|.::.|:. |..||
  Rat   513 LP--MQSLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLK-RPRGP 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	107/257 (42%)
Sik3	NP_001258145.2	STKc_SIK	65..317	CDD:270973	105/255 (41%)
		UBA_like_SF	346..390	CDD:473871	6/43 (14%)