DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4629 and AMPKalpha

DIOPT Version :9

Sequence 1:	NP_608564.3	Gene:	CG4629 / 33284	FlyBaseID:	FBgn0031299	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	141/542 - (26%)
Similarity:	234/542 - (43%)	Gaps:	102/542 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 RIGLYRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVVDLDR-AGLDAKALRMLSSEIATLECVHHP 125
            :||.|.....:|.|.|.|||:..||:||.|||:|:::..: ..||  .:..:..||..|:...||
  Fly    24 KIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLD--VVGKIRREIQNLKLFRHP 86

  Fly   126 NILRLFEVVETLGRVYLVTEWIRGGELYNHITQGGPLREIHAAPLLKQLLLAVKHMHSLGYVHRD 190
            :|::|::|:.|...::::.|::.||||:::|.:.|.|:|..|....:|::..|.:.|....||||
  Fly    87 HIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRD 151

  Fly   191 IKAENVLLLSEDRLKLADFGFSTQLINGANQKLDTFCGSPPYAAPELFSDDHYIGAPVDVWALGI 255
            :|.||:||.....:|:||||.|..:::|  :.|.|.||||.|||||:.|...|.|..||:|:.|:
  Fly   152 LKPENLLLDHNMHVKIADFGLSNMMLDG--EFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGV 214

  Fly   256 LLYFMVVGNMPFRAPTIPGLKAAILKGDYLLPGQLSLPCIRLIQRILIHIPAQRPTIDDMLNSQF 320
            :||.::.|.:||....:|.|...|..|.:.:|..|:...:.|:.::|...|.:|..|:::...::
  Fly   215 ILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEW 279

  Fly   321 VTCPKLSADLMQWEINQHTKPVKR-------SIFWVR-SKSHRLRKSASLRDRYAEVVKKPAISM 377
            .. ..|.|.|....|.|.:..:..       :.|.|: ::.|....|....|:.|  :....|..
  Fly   280 FQ-KDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLA--IAYHLIID 341

  Fly   378 NTRQQDEMF-----VQNFL----------QPI---EMGHE---LLVPVSSQLKEPQSTEQAKRPT 421
            |.|..|:..     :.||.          .|:   .|.|:   ..|.|.........|.....|.
  Fly   342 NKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPV 406

  Fly   422 RRYMFCGSLKKKVTPMETEPE-------KQLANGGQSIGSAKINPWNVEVAEDCPLFKNYDAETG 479
                 .|.......|:...||       :|||...|:.|..              .|....|..|
  Fly   407 -----AGGTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGG--------------AFPEKTARGG 452

  Fly   480 SCVMLPTNTEDLSQLGALEFEARQILAELGLTSEMLINARQSGPRSDIIGAYRI---------VV 535
            :.:                   ::....||:.|       ||.|...::..||.         ::
  Fly   453 TPI-------------------KRAKWHLGIRS-------QSKPNDIMLEVYRAMKALSYEWKII 491

  Fly   536 N----RLQKQSWLARKHVEMAL 553
            |    |:::|:....|..:|:|
  Fly   492 NPYHVRVRRQNVKTGKFSKMSL 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	91/258 (35%)
CG4629	NP_608564.3	S_TKc	66..321	CDD:214567	89/255 (35%)
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	91/258 (35%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	11/64 (17%)
		AMPKA_C	457..580	CDD:213378	14/64 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940