DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4629 and CG8485

DIOPT Version :9

Sequence 1:	NP_608564.3	Gene:	CG4629 / 33284	FlyBaseID:	FBgn0031299	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_610942.2	Gene:	CG8485 / 36579	FlyBaseID:	FBgn0033915	Length:	860	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	156/558 - (27%)
Similarity:	249/558 - (44%)	Gaps:	88/558 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LQCDPRCGHEVTIGRRIGLYRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVVDLDRAGLDAKALRM 111
            |:..|..|  |:.|:..|||.....:|.|:|:.||||.|..|..|||:|||  |:..||..:...
  Fly     3 LETQPVGG--VSDGKIAGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVV--DKTKLDDVSKAH 63

  Fly   112 LSSEIATLECVHHPNILRLFEVVETLGRVYLVTEWIRGGELYNHITQ-GGPLREIHAAPLLKQLL 175
            |..|:..::.|.|||::||:||::|..::|||.|...||:||::|.: ...|.|..|....:|:|
  Fly    64 LFQEVRCMKLVQHPNVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQIL 128

  Fly   176 LAVKHMHSLGYVHRDIKAENVLLLSE-DRLKLADFGFSTQLINGANQKLDTFCGSPPYAAPELFS 239
            .|:.:.|.|..||||:|.|||:...: ..:||.|||||.:.:.|  |||:|||||..|:|||:..
  Fly   129 RAITYCHQLHVVHRDLKPENVVFFEKLGLVKLTDFGFSNKFLPG--QKLETFCGSLAYSAPEILL 191

  Fly   240 DDHYIGAPVDVWALGILLYFMVVGNMPFRAPTIPGLKAAILKGDYLLPGQLSLPCIRLIQRILIH 304
            .|.|....||:|:||::||.:|.|..||...........|:...|.:|..:|..|..||..:|:.
  Fly   192 GDSYDAPAVDIWSLGVILYMLVCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVR 256

  Fly   305 IPAQRPTIDDMLNSQFVTCPKLSADLMQWEINQHTKPVKRSIFWVRSKSHRL----RKSASLRDR 365
            .|.:|.|::::.:|.::                  ||:........:..|.|    |:.....|
  Fly   257 DPKKRATVEEIASSAWL------------------KPIDEPDSTTSTSEHFLPLVSREQLGEED- 302

  Fly   366 YAEVVKKPAISMNTRQQDEMFV---QNFLQPIEMGHELLVPVSSQLKEPQSTEQAKRPTRRYMFC 427
            :|.:::| .|:.|...::|:..   :|....|...:.||..:..:.:..:..::.:......|..
  Fly   303 HAFIIQK-MINGNIASKEEILQALDKNKYNHITATYFLLAELRLRRRREELAQKQRLLNDASMKV 366

  Fly   428 GSLKKKVTPMETEPEKQLANGGQSIGSAKINPWNVEVAED----------CPLFKNYDAETGSCV 482
            |...:|:.|.:..| .:...||..| |..:.| ..:.|.|          |.:.:..|.|..:.
  Fly   367 GDASRKLVPEKPSP-TEAQKGGVPI-SINVTP-AAQFANDGGKPDKRSRKCSIVREEDEEESAT- 427

  Fly   483 MLPTNTEDLSQLGALEFEARQILAELGLTSEMLINARQSGPRSDIIGAYRIVVNRLQKQSWLARK 547
                             |...:..||.:||.....|....|.|      |.:..|...:.....|
  Fly   428 -----------------ECTAVGNELKVTSSSRREAFSDSPFS------RSIHERSSSEPGNQTK 469

  Fly   548 HVEMA-----LHSEPKVE-----------KRIERSCCI 569
            ..::|     .||..|:.           |::|:|..|
  Fly   470 GEQIANSGVPSHSRTKIVVSVDATLAHKLKQMEKSAKI 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	102/259 (39%)
CG4629	NP_608564.3	S_TKc	66..321	CDD:214567	100/256 (39%)
CG8485	NP_610942.2	STKc_SNRK	16..273	CDD:270976	102/260 (39%)
		S_TKc	20..273	CDD:214567	100/256 (39%)
		UBA_SNRK	296..338	CDD:270524	8/43 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461625
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940