Protein Alignment CG4629 and chk-1

DIOPT Version :10

• Sequence 1: NP_608564.3
• Gene: CG4629 / 33284
• FlyBaseID: FBgn0031299
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: NP_001380036.1
• Gene: chk-1 / 3565921
• WormBaseID: WBGene00000498
• Length: 503
• Species: Caenorhabditis elegans
• Alignment Length: 565
• Identity: 135/565 - (23%)
• Similarity: 228/565 - (40%)
• Gaps: 137/565 - (24%)

  Fly    22 TTTTTPLTICQPPPPTPPYQRLTKALQCDPRCGHEVTIGRRIGLYRFCGDIGRGNFSKVKLAVHQ 86
            :||:||......|.              .|.           .|||....:|.|.|.:|.|.|:.
 Worm     5 STTSTPAAAAVAPQ--------------QPE-----------SLYRVVQTLGEGAFGEVLLIVNT 44

  Fly    87 LTRD-KVAIKVVDLDRAGLD----AKALRMLSSEIATLECVHHPNILRLFEVVETLGRVYLVTEW 146
            ...: ..|:|.:::.....|    .:...:|...::   .|.|.|::|:..:.......||..|:
 Worm    45 KNPEVAAAMKKINIANKSKDFIDNIRKEYLLQKRVS---AVGHDNVIRMIGMRNDPQFYYLFLEY 106

  Fly   147 IRGGELYNHITQGGPLREIHAAPLLKQLLLAVKHMHSLGYVHRDIKAENVLLLSEDRLKLADFGF 211
            ..||||::.|.....:..:.|....|||:..:|.:|....||||||.||:||.....||::|||.
 Worm   107 ADGGELFDKIEPDCGMSPVFAQFYFKQLICGLKFIHDNDVVHRDIKPENLLLTGTHVLKISDFGM 171

  Fly   212 STQLIN-GANQKLDTFCGSPPYAAPELFSDDHYIGAPVDVWALGILLYFMVVGNMPFRAPTIPGL 275
            :|...| |..:.||..||:.|||||||.:...|.|.|||||:.||:|..|:.|.:|:.
 Worm   172 ATLYRNKGEERLLDLSCGTIPYAAPELCAGKKYRGPPVDVWSSGIVLIAMLTGELPWD------- 229

  Fly   276 KAAILKGDYLLPGQLS-------------LPCIRLIQRILIHIPAQRPTIDDMLNSQFVTCPKLS 327
            :|:.....|:  |.:|             :..:.::::|:.....:|.||:           ::.
 Worm   230 RASDASQSYM--GWISNTSLDERPWKKIDVRALCMLRKIVTDKTDKRATIE-----------QIQ 281

  Fly   328 ADLMQWEINQHT---------KPVKRSIFWVRSKSHRL----RKSASLRDRYAEVVKKPAISMNT 379
            ||  .|  .||.         :|:||:    |:....:    :...|.:.|:.|...:.: ::..
 Worm   282 AD--PW--YQHNFGQVETPNGRPLKRA----RNNDENITCTQQAECSAKRRHLETPNEKS-TLAE 337

  Fly   380 RQQDEMFVQNFLQPIEMGHELLVPVSSQLKEPQSTEQAKRPTRRYMFCGSLKKKVTPMETEPEKQ 444
            ||.     .:|.||.:. .:||:.....:.:..|....:...|...||     .||.:.:..:|
 Worm   338 RQN-----ASFSQPTKT-EDLLLTQHIDMSQTNSNLLQRMVCRMTRFC-----VVTDIRSTYQK- 390

  Fly   445 LANGGQSIGSAKINPWNVEVAEDCPLFKNYDAETGSCVMLPTNTEDLSQLGALEFEARQILAELG 509
            :|...:..|      :.|...:|..|...: .|....|.|.|       :|.:..:.|
 Worm   391 VARASEHAG------FGVRETDDYRLLVTW-REVSMMVSLYT-------MGDIPDKPR------- 434

  Fly   510 LTSEMLINARQSGPRSDIIGAYRI---VVNRLQK------QSWLA 545
                ::::.|:|  |.|.|...::   |.||:.:      .:|||
 Worm   435 ----VMVDFRRS--RGDGIQFKKMFMDVRNRMHEWICTDGNNWLA 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	81/276 (29%)
chk-1	NP_001380036.1	STKc_Chk1	22..286	CDD:270971	84/290 (29%)