DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4629 and Nim1k

DIOPT Version :9

Sequence 1:	NP_608564.3	Gene:	CG4629 / 33284	FlyBaseID:	FBgn0031299	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_780747.1	Gene:	Nim1k / 245269	MGIID:	2442399	Length:	436	Species:	Mus musculus

Alignment Length:	544	Identity:	183/544 - (33%)
Similarity:	260/544 - (47%)	Gaps:	166/544 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PYQRLTKALQCDPRCGHEVTIGRRIGLYRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVVDLDRAG 103
            |:::||:.:..|.:...|:|:|:|||.||..|:||.||||:|||.:|.||::|||||:  ||:..
Mouse    47 PFEKLTQDMCQDEKVVREITLGKRIGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKI--LDKTK 109

  Fly   104 LDAKALRMLSSEIATLECVHHPNILRLFEVVETLGRVYLVTEWIRGGELYNHITQGGPLREIHAA 168
            ||.|..|:||.||:::|.:|||||:||:||||||.:::||.|:..||||:..|:..|.|.|..:.
Mouse   110 LDQKTQRLLSREISSMEKLHHPNIVRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESK 174

  Fly   169 PLLKQLLLAVKHMHSLGYVHRDIKAENVLLLSEDRLKLADFGFSTQLINGANQKLDTFCGSPPYA 233
            .:..|:|.||||||....:|||:|||||...|...:|:.||||||  ::...:.|:|||||||||
Mouse   175 LIFSQILSAVKHMHENQIIHRDLKAENVFYTSRTCVKVGDFGFST--VSKKGEMLNTFCGSPPYA 237

  Fly   234 APELFSDDHYIGAPVDVWALGILLYFMVVGNMPFRAPTIPGLKAAILKGDYLLPGQLSLPCIRLI 298
            |||||.|.||:|..||:||||:||||||.|.|||||.|:..||.:||:|.|.:|..:|.||.|||
Mouse   238 APELFRDQHYVGVYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYTIPQHVSEPCHRLI 302

  Fly   299 QRILIHIPAQRPTIDDMLNSQFVTCPKLSADLMQWEINQHTKPVKRSIFWVRSKSHRLRKSASLR 363
            :.:|...|.:|..|:.:::::                            |:|.
Mouse   303 RGVLQPTPTERYGINYIMSNE----------------------------WMRG------------ 327

  Fly   364 DRYAEVVKKPAISMNTRQQDEMFVQNFLQPIEMGHELLVPVSSQLKEPQSTEQAKRPTRRYMFCG 428
                                                  ||..
Mouse   328 --------------------------------------VPYP----------------------- 331

  Fly   429 SLKKKVTPMETEPEKQLANGGQSIGSAKINPWNVEVAEDCPLFKNYDAETGSCVMLPTNTEDLSQ 493
                  ||:|                    |:.::                     |.:..:.|.
Mouse   332 ------TPLE--------------------PFQLD---------------------PKHLSETST 349

  Fly   494 LGALEFEARQILAELGLTSEMLINARQSGPRSDIIGAYRIVVNRLQKQSWLARKHVEMALHSEPK 558
            |...|.|.:..|..||:|.|.:.|.:....||.|.|.|||:::|:|::.  |.:.|.:.:..|||
Mouse   350 LKEEENEVKSTLEHLGITDEHIRNNQGRDARSSITGVYRIILHRVQRRK--ALESVPIMILPEPK 412

  Fly   559 VE-----KRIERS-------CCIL 570
            ..     .||.|.       |.||
Mouse   413 ERDLKKGSRIYRGIRHTSKFCSIL 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	136/257 (53%)
CG4629	NP_608564.3	S_TKc	66..321	CDD:214567	134/254 (53%)
Nim1k	NP_780747.1	STKc_NIM1	71..325	CDD:270977	136/285 (48%)
Nim1k	NP_780747.1	S_TKc	74..325	CDD:214567	134/282 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850521
Domainoid	1	1.000	266	1.000	Domainoid score	I1876
eggNOG	1	0.900	-	-		E33208_3BBHD
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	335	1.000	Inparanoid score	I2394
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005598
OrthoInspector	1	1.000	-	-		oto92842
orthoMCL	1	0.900	-	-		OOG6_108315
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3502
SonicParanoid	1	1.000	-	-		X4010
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.780