Protein Alignment CG4629 and SIK3

DIOPT Version :10

• Sequence 1: NP_608564.3
• Gene: CG4629 / 33284
• FlyBaseID: FBgn0031299
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: NP_001353615.1
• Gene: SIK3 / 23387
• HGNCID: 29165
• Length: 1369
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 160/585 - (27%)
• Similarity: 265/585 - (45%)
• Gaps: 118/585 - (20%)

  Fly    15 PPHP--PPLTTTTTPLTICQPPPPTPPYQRLTKALQCDPRCGHEVTIGRRIGLYRFCGDIGRGNF 77
            ||.|  |......:| ...||.||.|..:....|               |||.|.....||:|||
Human    29 PPAPGSPAAPAAVSP-AAGQPRPPAPASRGPMPA---------------RIGYYEIDRTIGKGNF 77

  Fly    78 SKVKLAVHQLTRDKVAIKVVDLDRAGLDAKALRMLSSEIATLECVHHPNILRLFEVVETLGRVYL 142
            :.||.|.|.:|:.|||||::  |:..||.:.|:.:..|:..::.:.||:|:||::|:||...:||
Human    78 AVVKRATHLVTKAKVAIKII--DKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYL 140

  Fly   143 VTEWIRGGELYNHITQGGPLREIHAAPLLKQLLLAVKHMHSLGYVHRDIKAENVLLLSEDRLKLA 207
            |||:..|||:::|:...|.:.|..|....||::.||...|....||||:||||:||.:...:|:|
Human   141 VTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 205

  Fly   208 DFGFSTQLINGANQKLDTFCGSPPYAAPELFSDDHYIGAPVDVWALGILLYFMVVGNMPFRAPTI 272
            |||||.....|  |.|.|:||||||||||||....|.|..||:|:||::||.:|.|.:||...|:
Human   206 DFGFSNLFTPG--QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL 268

  Fly   273 PGLKAAILKGDYLLPGQLSLPCIRLIQRILIHIPAQRPTIDDMLNSQFV-------TCPKLSADL 330
            ..|:|.:|.|.:.:|..:|..|..||:.:|:..|.:|.:::.:...:::       ...:|.|:.
Human   269 QNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAEC 333

  Fly   331 MQWEINQHTKPVKR--------------------------------SIFWVRSKSHRLRKSASLR 363
            .|.:..:...|:..                                |:...|.|.|:..:..:|.
Human   334 QQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALP 398

  Fly   364 DRYAEVVKKPAISMNTRQQDEMFVQNFLQPIEMGHELLVPVSSQLKEPQST-----EQAKRPTR- 422
            .....:..:..:::...|      ......|.:....|:...:|:.||..|     ::.:.|:.
Human   399 SMPRALAFQAPVNIQAEQ------AGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPE 457

  Fly   423 ---RYMFCGSLKKKVTPMETEPEKQLANGGQSI--GSAKINPWN--VEVAEDCPLFKNYDAETGS 480
               ||:   |:::....: .:|..::....|.:  |...:||..  ::||.:.....|
Human   458 ALVRYL---SMRRHTVGV-ADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHN------- 511

  Fly   481 CVMLPTNTEDLSQLGALEFEARQIL----------------------AELGLTSEMLINARQSGP 523
              :||  .::|...|.||::.:.:|                      |.:.|.::.|:. |..||
Human   512 --LLP--MQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLK-RPRGP 571

  Fly   524  523
            Human   572  571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	107/257 (42%)
SIK3	NP_001353615.1	STKc_SIK	65..317	CDD:270973	105/255 (41%)
		UBA_SIK3	346..390	CDD:270593	3/43 (7%)