DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4629 and Mark4

DIOPT Version :9

Sequence 1:	NP_608564.3	Gene:	CG4629 / 33284	FlyBaseID:	FBgn0031299	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_758483.1	Gene:	Mark4 / 232944	MGIID:	1920955	Length:	752	Species:	Mus musculus

Alignment Length:	427	Identity:	135/427 - (31%)
Similarity:	219/427 - (51%)	Gaps:	75/427 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 IGLYRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVVDLDRAGLDAKALRMLSSEIATLECVHHPNI 127
            :|.||....||:|||:|||||.|.||..:||||::  |:..|:..:|:.|..|:..::.::||||
Mouse    56 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKII--DKTQLNPSSLQKLFREVRIMKGLNHPNI 118

  Fly   128 LRLFEVVETLGRVYLVTEWIRGGELYNHITQGGPLREIHAAPLLKQLLLAVKHMHSLGYVHRDIK 192
            ::||||:||...:|||.|:...||:::::...|.::|..|....:|::.||.:.|....||||:|
Mouse   119 VKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLK 183

  Fly   193 AENVLLLSEDRLKLADFGFSTQLINGANQKLDTFCGSPPYAAPELFSDDHYIGAPVDVWALGILL 257
            |||:||.:|..:|:||||||.:...|:  |||||||||||||||||....|.|..||:|:||::|
Mouse   184 AENLLLDAEANIKIADFGFSNEFTLGS--KLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVIL 246

  Fly   258 YFMVVGNMPFRAPTIPGLKAAILKGDYLLPGQLSLPCIRLIQRILIHIPAQRPTIDDMLNSQFVT 322
            |.:|.|::||....:..|:..:|:|.|.:|..:|..|..:::|.|:..||:|.|::.::..:::
Mouse   247 YTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI- 310

  Fly   323 CPKLSADLMQWEINQHTKP------VKR-----SIFWVRSKSHRLRKSASLRDRYAEV------- 369
                :......|:..:|:|      .||     .:.:.|.:.    |.|....:|.||
Mouse   311 ----NIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEI----KEALTNQKYNEVTATYLLL 367

  Fly   370 -------------------VKKPAISMNTRQQDEMFVQNFLQPIEMGHELLVPVSSQLKEPQSTE 415
                               |:.|:.:.|.....:                   .||..|..:::.
Mouse   368 GRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSK-------------------GSSHNKGQRASS 413

  Fly   416 QAKRPTRRYM-FCGSLKKKVTPMETEPEKQLANGGQS 451
            ......||:. |||.     :|....|::...:.|.:
Mouse   414 STYHRQRRHSDFCGP-----SPAPLHPKRSPTSTGDT 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	110/257 (43%)
CG4629	NP_608564.3	S_TKc	66..321	CDD:214567	109/254 (43%)
Mark4	NP_758483.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		STKc_MARK	58..310	CDD:270974	109/255 (43%)
		S_TKc	59..310	CDD:214567	109/254 (43%)
		UBA_MARK3_4	328..370	CDD:270590	8/45 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..615		14/85 (16%)
		MARK4_C	654..752	CDD:213382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910